AutismKB 2.0

Annotation Detail for MFHAS1


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Basic Information Top
Gene Symbol:MFHAS1 ( FLJ23354,LRRC65,MASL1 )
Gene Full Name: malignant fibrous histiocytoma amplified sequence 1
Band: 8p23.1
Quick LinksEntrez ID:9258; OMIM: 605352; Uniprot ID:MFHA1_HUMAN; ENSEMBL ID: ENSG00000147324; HGNC ID: 16982
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
Conduct disorder (interaction)
PSYCH
Desease Name
Conduct disorder (interaction)
Desease Name
Malignant fibrous histiocytoma
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MFHAS1 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of MFHAS1 mRNAincreases expression 19774075
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MFHAS1 mRNAdecreases expression 19150397
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MFHAS1 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of MFHAS1 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MFHAS1 mRNAaffects cotreatment|affects expression 17602206
D010656 Phenylephrine Phenylephrine results in decreased expression of MFHAS1 mRNAdecreases expression 18158353
C025643 vinclozolin vinclozolin affects the expression of MFHAS1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma Diethylnitrosamine 2.9810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.2418056438 17620307 16434500 19061943 17162532 19052882
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 9.9118218290 20041841 18057881
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 9.9117460149
MESH:D001281 Atrial Fibrillation Amiodarone 4.0819698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.1419483382
MESH:D001919 Bradycardia Phenylephrine 4.8815306635
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.943084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.9420935162 20727157 17428255 17055752 16698587 19052882 18056438 17138121 16681979 10672840 20084675 18393292 19107877 20514400 3581430 20524982 19394651 19701751 18978308 18788625 19335982 18506893 10737359 16878318 20512989 20214788 17162532 17173139 18785209 18210153 20432363 16288022 18691550 17978847 20007298 19171122 18971187 11831363 16807293 3084413 19822196 19208518 19418558 16935385 18665156 16328049 16540662 19539802 16830150 16569478 16779866 17761372 19919837 16502159 18494052 20101231 19383236 21159647 19519916
MESH:D006332 Cardiomegaly Phenylephrine 3.6511754973 17124262 11179087 15728586 16170337 17287366
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9619225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4218974383
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.0920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.0912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.0917174075 21159647 2727394 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6016081117 19420014 11461765 11743745 19739265 15619225 11287661 17522070 14725611 16485898 12958197 19370779 10915739 2444490 16227642 11529661 16109766 19923254 19416960 11421492 16781746 12540782 11834606 12392966 18071297 18713872 14986274 16393943 16177239 14550746 17906064 12594235 12705907 12153990 19085960 10663392 15968718 19164858 10774834 17562736 11739529
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.6018218290 15265979
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6019107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1220426865
MESH:D005234 Fatty Liver Amiodarone 14.6114986274
MESH:D005234 Fatty Liver Cyclosporine 14.6119224547
MESH:D005234 Fatty Liver Diethylnitrosamine 14.6120387270 21071580
MESH:D005355 Fibrosis Cyclosporine 3.4512639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly Amiodarone 4.0515265979
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.129751232 8137927
MESH:D006973 Hypertension Cyclosporine 5.6310903974
MESH:D006973 Hypertension Phenylephrine 5.638949925 12717712
MESH:D006984 Hypertrophy Phenylephrine 4.8012791704 18502941
MESH:D007037 Hypothyroidism Amiodarone 4.8217991464 18020914
MESH:D007248 Infertility, Male vinclozolin 3.1916467254
MESH:D007249 Inflammation Diethylnitrosamine 2.4818785209
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2215629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.2218776723 8314463 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008064 Lipidoses Amiodarone 3.6815342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9420032147 19638242 18522880 18665156 18407596
MESH:D008107 Liver Diseases Acetaminophen 4.0812969438 12587719 19460945 16610002 19784758 16611625 11587558 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0817034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Clofibric Acid 5.0217602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 5.0212112319 15885732 12771043 20501860 18648771 10737359 19294768 20492335 20452335 21047994 20137499 2862719 18644402 2422723 18754104 19850985 19812893 19642983 19638242 21167192 20101389 19090486 21278145 21071580 19499222 19551842 19426721 16942905 19690152 19833225 15175105 18978307 19254457 20434301 18977376 19996281 9163691 19073162 20405173 19255062 19256749 20118626 20583210 19427195
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7716267830 17854601 18253720 17942915 18775883 17174075 18544905 16842330 18164116 9362446 18079962 3124819 19539802 19004024 18308698 19009564 21159647 2563599 19519916 19126423 18093689 18282651
MESH:D008133 Long QT Syndrome Amiodarone 3.7617391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 3.5312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8518516814
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620512841 21163286 6695378 20970405
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009181 Mycoses Amiodarone 5.2817974566 12754197
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.659029167 3581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D011230 Precancerous Conditions Cyclosporine 9.6712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.672563599
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2318042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9312832656 12490602 11597910
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4218724381
MESH:D012852 Sinusitis Phenylephrine 5.047327846
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013276 Stomach Ulcer Amiodarone 3.5518087811
MESH:D013610 Tachycardia Amiodarone 4.5711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4719225199
MESH:D013959 Thyroid Diseases Amiodarone 5.1319731979
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.167505956
MESH:D013971 Thyrotoxicosis Amiodarone 5.1718020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.5311989578 17467628
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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