AutismKB 2.0

Annotation Detail for TIFA


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Basic Information Top
Gene Symbol:TIFA ( MGC20791,T2BP,T6BP,TIFAA )
Gene Full Name: TRAF-interacting protein with forkhead-associated domain
Band: 4q25
Quick LinksEntrez ID:92610; OMIM: 609028; Uniprot ID:TIFA_HUMAN; ENSEMBL ID: ENSG00000145365; HGNC ID: 19075
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TIFA mRNAdecreases expression 20382639
D010634 Phenobarbital Phenobarbital results in increased expression of TIFA mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in decreased expression of TIFA mRNAdecreases expression 17426115
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of TIFA mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 4.076195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 12.3217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 12.3216434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 1.9517173139 20935162 1701930 20007298 6705139
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9820889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.814080065
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.7216684804
MESH:D004421 Dystonia Phenobarbital 4.471851702
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.673659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.5911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.916401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.817750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.653659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1520426865
MESH:D005234 Fatty Liver pirinixic acid 3.1919236843 20131406
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006529 Hepatomegaly Phenobarbital 10.4116109766
MESH:D006529 Hepatomegaly pirinixic acid 10.4119176532 16221962 18467677 19772884
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0821047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Phenobarbital 2.2419363144
MESH:D008113 Liver Neoplasms Phenobarbital 4.878742319 19482888 19812893 19073162 15975961 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 4.8720007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.926150874 18308698 1399818 17172636 2563599
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.1117484760
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010018 Osteomalacia Phenobarbital 5.0017016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.6016965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.992563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.2212752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012640 Seizures Phenobarbital 2.954039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.456407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.361399818
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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