AutismKB 2.0

Annotation Detail for DNER


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Basic Information Top
Gene Symbol:DNER ( UNQ26,bet )
Gene Full Name: delta/notch-like EGF repeat containing
Band: 2q36.3
Quick LinksEntrez ID:92737; OMIM: 607299; Uniprot ID:DNER_HUMAN; ENSEMBL ID: ENSG00000187957; HGNC ID: 24456
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200013Notch signaling pathway
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of DNER mRNAdecreases expression 20406850
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DNER proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of DNER mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of DNER mRNAincreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DNER mRNAincreases expression 17942748
D005472 Fluorouracil Fluorouracil results in increased expression of DNER mRNAincreases expression 16510598
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5514692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.5517638652
MESH:D000740 Anemia Fluorouracil 4.0217963324 15504547 16511603
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001943 Breast Neoplasms Calcitriol 2.3611237771
MESH:D001943 Breast Neoplasms Fluorouracil 2.3619217205 16110121 15136595 16557594 18357371 18608205 16595493
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 3.8217121937
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8616705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.8612907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.8617971768 16799960 17045692 17088986 16332177 18930000
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1418695887
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.1011237771
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 5.1018986760 16280240 17066447 16757204
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.276135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D002779 Cholestasis Cyclosporine 8.5519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.5517681005 17110522 16919318 15861022 16105132 11677210 17333356
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2716340194 17725105 17016597 16510598 17172411 15001691 18772588 17169374 17018589 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018448328 16303861 17016601 18509181 16391804 17401013 15289873 17454858 18802399 16524972 14970324 16282729 17255274 15148649 17695437 16331619 17094418 18383874 18288408 20501625 17594712 18949393
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.4418551238
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0421346803 18551238
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 10.3915138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.3912538720
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5115173087 17638652 16337965 16481741 16785472
MESH:D005234 Fatty Liver Cyclosporine 8.6819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6815345470
MESH:D005355 Fibrosis Cyclosporine 3.5612639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5915162350 18337622 15102660
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.0216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 14.0212371664
MESH:D007680 Kidney Neoplasms Fluorouracil 14.0216985049
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 8.097678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 8.092125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Fluorouracil 8.0918383874 17045692 16603448 15113037
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.582876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.588603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.6514755239
MESH:D008175 Lung Neoplasms Fluorouracil 2.6515246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8718986760 16757204
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.3218551238 7678174
MESH:D009369 Neoplasms Fluorouracil 2.7416928823 18600527 18239605
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7416049721
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7519003803 15113037 16929163 16500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.2415572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3716644109 16289102 12479363 15754350 18247401
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3719082440 18626508
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3018722050 18286688 15538739 16160472
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7418551238
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017522103 15786421 16424979 17172411 18396642 16951190 19084572 18567086 19015929 17498489
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2916280240
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3916049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7810091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1816803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8715869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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