AutismKB 2.0

Annotation Detail for REEP6


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Basic Information Top
Gene Symbol:REEP6 ( C19orf32,DP1L1,FLJ25383,TB2L1 )
Gene Full Name: receptor accessory protein 6
Band: 19p13.3
Quick LinksEntrez ID:92840; OMIM: 609346; Uniprot ID:REEP6_HUMAN; ENSEMBL ID: ENSG00000115255; HGNC ID: 30078
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of REEP6 mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of REEP6 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of REEP6 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of REEP6 proteinaffects expression 20106945
D001241 Aspirin Aspirin results in increased expression of REEP6 mRNAincreases expression 11906190
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of REEP6 mRNAaffects cotreatment|increases expression 18164116
D016572 Cyclosporine Cyclosporine results in decreased expression of REEP6 mRNAdecreases expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of REEP6 mRNAaffects cotreatment|decreases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of REEP6 mRNAaffects cotreatment|decreases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in decreased expression of REEP6 mRNAaffects cotreatment|decreases expression 16931933
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of REEP6 mRNAaffects cotreatment|increases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of REEP6 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of REEP6 mRNAaffects cotreatment|increases expression 17942748
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of REEP6 mRNAaffects cotreatment|decreases expression 16931933
D015735 Mifepristone Mifepristone results in decreased expression of REEP6 mRNAdecreases expression 17584828
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of REEP6 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of REEP6 mRNAincreases expression 17426115
16221962
D019258 Saquinavir [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of REEP6 mRNAaffects cotreatment|decreases expression 16931933
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of REEP6 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of REEP6 mRNAincreases expression 19465110
C066340 tolcapone tolcapone binds to REEP6 proteinaffects binding 19783845
D014635 Valproic Acid Valproic Acid results in increased expression of REEP6 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin results in decreased expression of REEP6 mRNAdecreases expression 18042343
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of REEP6 mRNAaffects cotreatment|decreases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of REEP6 mRNAaffects cotreatment|decreases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in decreased expression of REEP6 mRNAaffects cotreatment|decreases expression 16931933
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 13.927525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.9214514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 13.928875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8619490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.769612607
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8014692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.003712494
MESH:D000236 Adenoma beta-Naphthoflavone 11.0019389873
MESH:D000236 Adenoma Diethylnitrosamine 11.0010737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.9317162532 19052882 18056438 17620307 16434500 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.9316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.9316835633
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.2411080934
MESH:D000544 Alzheimer Disease tolcapone 3.2720150427
MESH:D000550 Amblyopia Valproic Acid 5.1817688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D001008 Anxiety Disorders Valproic Acid 8.6717497229
MESH:D001008 Anxiety Disorders vinclozolin 8.6719015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6215885639
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.6420485159 12372130
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8517507914 16609825 18316065 17688650 15238991 18558336 20603192 18177632 18985861 18396377 18940202 19232924 17157402 19460635 18775368
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.961440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.0417594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.5619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.5612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.8815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.888888407
MESH:D001932 Brain Neoplasms Aspirin 4.3515481559
MESH:D001943 Breast Neoplasms Aspirin 1.9615161893
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.477296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.473084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.4721507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.4716830150 20214788 16807293 18210153 11831363 18971187 16540662 17055752 19335982 16681979 17428255 19208518 19394651 18393292 20084675 17761372 20524982 20514400 17138121 18494052 21159647 18691550 18506893 17162532 18785209 19539802 19519916 18056438 16288022 16878318 3581430 16502159 20007298 20101231 17173139 20512989 18978308 10737359 20935162 19919837 17978847 19052882 16779866 19383236 19822196 16328049 19171122 18788625 16698587 16569478 3084413 20727157 18665156 19107877 10672840 19701751 19418558 20432363 16935385
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.647296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3316120746 18670907 18850075
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.2914694615
MESH:D002386 Cataract Acetaminophen 7.2910977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.887505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.8812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.8817174075 21159647 2727394 7505956
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6820734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.1319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.1316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 18.809022650 19486331
MESH:D002779 Cholestasis Cyclosporine 18.8019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 18.8015861022 17681005 16919318 11677210 17110522 17333356 16105132
MESH:D002779 Cholestasis pirinixic acid 18.8019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0816354765 15340226 12621046 8697196 15668235
MESH:D003110 Colonic Neoplasms Aspirin 2.9712411196
MESH:D015179 Colorectal Neoplasms Aspirin 2.7517047198
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.9915095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.9917141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4520055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.4517688650 16575769 8888407
MESH:D003456 Cryptorchidism vinclozolin 4.2814966744
MESH:D003866 Depressive Disorder tolcapone 4.267768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 4.8410440460
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7411906362 12868966 8970840 8156756 14531868 2524372 11298694 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.433621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1720387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1717107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 18.4118692083 16192314 9653073 7440962 8291058 1440618 6482804 18289764 11289319 9022650 6679447 9328219 18648102
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 18.4121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.4112153990 16227642 16393943 12958197 19923254 16109766 2444490 15968718 12392966 15619225 11529661 16177239 19164858 10915739 11743745 14986274 19416960 10774834 12705907 16081117 18713872 17906064 17562736 11421492 16781746 19085960 14725611 17522070 19370779 11834606 19739265 19420014 18071297 12594235 10663392 14550746 11461765 11739529 12540782 11287661 16485898
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 18.4119107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.4120420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 18.4119783845 16604736
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 18.411733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Lamivudine 13.5915040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 13.5911462148
MESH:D004362 Drug Toxicity Zidovudine 13.5915040536
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.3411455177
MESH:D004421 Dystonia Valproic Acid 3.991851702
MESH:D004487 Edema Aspirin 11.1517259670
MESH:D004487 Edema pirinixic acid 11.1512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.1511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1212538720
MESH:D004715 Endometriosis Mifepristone 8.9516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.959294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.0917275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.863922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.536426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.237750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.003659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0616302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.093581430
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 5.8919578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver Cyclosporine 29.9419224547
MESH:D005234 Fatty Liver Diethylnitrosamine 29.9421071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.9415345470
MESH:D005234 Fatty Liver pirinixic acid 29.9420131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 29.9414986274 19224547
MESH:D005234 Fatty Liver Zidovudine 29.9418299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.078888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.966705139
MESH:D005355 Fibrosis Cyclosporine 8.2712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.2720067830
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2416417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D005909 Glioblastoma Aspirin 3.9112870263
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.977505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006261 Headache Aspirin 4.9015240983
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3011294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5020558911
MESH:D006402 Hematologic Diseases Zidovudine 4.6512579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.456705139
MESH:D006509 Hepatitis B Lamivudine 5.0417703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.0415309715 16476009 15274664 15631357 12044531
MESH:D006529 Hepatomegaly pirinixic acid 8.0519176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.0516120746 15340226 12621046
MESH:D015658 HIV Infections Indinavir 15.2411363243 15388451 11141242
MESH:D015658 HIV Infections Lamivudine 15.2411141242 9296927 20032539 17530837
MESH:D015658 HIV Infections Saquinavir 15.2415388451 11141242
MESH:D015658 HIV Infections Zidovudine 15.2417358032 20032539 11141242 11698656 11363243
MESH:D006849 Hydrocephalus Valproic Acid 4.8117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9918606429 8697196 16354765 15340226 16959395
MESH:D012001 Hyperacusis Aspirin 5.7115240983
MESH:D006930 Hyperalgesia Acetaminophen 2.6516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8815034207
MESH:D006973 Hypertension Cyclosporine 4.8610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5117937319
MESH:D007248 Infertility, Male vinclozolin 6.5116467254
MESH:D007249 Inflammation Diethylnitrosamine 4.7818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.7812200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.5916306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.968074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007674 Kidney Diseases Acetaminophen 5.6712587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.678314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.156582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.1512371664
MESH:D007680 Kidney Neoplasms Zidovudine 12.1512579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.3520370541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1416294345 17596541
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6716417039
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7918665156 19638242 18407596 20032147 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1515034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1112878042
MESH:D008107 Liver Diseases Acetaminophen 3.8516610002 12969438 11587558 19784758 16611625 19014921 12587719 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 3.8517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1816871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.9818177683 2125692 9163691 15890375
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 13.9819389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.9819499222 20452335 19642983 18648771 19833225 19254457 19073162 19551842 19427195 19812893 20137499 15175105 19255062 2422723 19638242 19090486 21167192 15885732 21047994 20434301 9163691 19850985 20583210 18977376 20492335 18754104 19256749 20501860 10737359 20101389 16942905 18978307 20405173 20118626 12771043 18644402 12112319 19690152 21071580 19426721 19996281 19294768 2862719 21278145
MESH:D008113 Liver Neoplasms pirinixic acid 13.9815890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.9816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 18.211399818 6587162 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 18.218603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 18.2118164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.213124819 16267830 19126423 18544905 19519916 19009564 18308698 18079962 18253720 19539802 9362446 21159647 18093689 17854601 18282651 19004024 18775883 17174075 18164116 2563599 16842330 17942915
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.2112151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2117228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.8114755239
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.8120970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8119555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 4.8118800350
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.7817358032
MESH:D008881 Migraine Disorders Aspirin 7.7015240983
MESH:D008881 Migraine Disorders Valproic Acid 7.7018803445 18765137
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.968888407
MESH:D009164 Mycobacterium Infections Indinavir 5.3621442799
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1217596541
MESH:D009203 Myocardial Infarction Aspirin 5.8412692751
MESH:D009203 Myocardial Infarction pirinixic acid 5.8419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8916411023
MESH:D009325 Nausea Aspirin 5.1615240983
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.613581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.619029167 3581430
MESH:D009369 Neoplasms pirinixic acid 1.9217405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2319348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.116679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.1116359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.9918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.9920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0620387270
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.936482804 4026338
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 8.9314694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.963988306
MESH:D010003 Osteoarthritis Aspirin 4.027009135
MESH:D010051 Ovarian Neoplasms Mifepristone 3.1116525653
MESH:D010146 Pain Acetaminophen 6.7516870215
MESH:D010146 Pain Aspirin 6.756995502 6363464
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4016540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.427296757
MESH:D010300 Parkinson Disease tolcapone 3.5720334432 9591521 9333106 11586115 7566641 9708959 11746615 9754991 11432539 8739811 11793426 9305320 10651109 8635184 17089403 19783845 18328768 20216409 19578428 16758261 1977408
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.4811156591
MESH:D020795 Photophobia Aspirin 5.7115240983
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.416228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.7512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.752563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.8911896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 15.8920603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 15.8919015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.8718220299
MESH:D011472 Prostatitis vinclozolin 4.8718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.2516919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.4911422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.323692021
MESH:D012206 Rhabdomyolysis Lamivudine 5.479296927
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.1119155313
MESH:D012220 Rhinitis Aspirin 4.3112372130
MESH:D012559 Schizophrenia Valproic Acid 2.0615737665 19110320
MESH:D012640 Seizures Valproic Acid 2.6916876388 11044598 11738929 15475178 3137016 14763951 1511512 17978042
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.2012269725
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8916709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4912833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6518456281
MESH:D013274 Stomach Neoplasms Zidovudine 2.6517696246
MESH:D020521 Stroke Aspirin 4.3216403987
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Aspirin 9.0017672075
MESH:D013927 Thrombosis Ethinyl Estradiol 9.0015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.956582329 1399818 6587162 7505956 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.957505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.1817262798
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 5.8919578428
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.463119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.258074119
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.588888407
MESH:D014581 Urticaria Acetaminophen 8.6910982225
MESH:D014581 Urticaria Aspirin 8.6920485159 10982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.6912579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4814671159 15869587
MESH:D014820 Vitiligo tolcapone 5.1310573327
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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