AutismKB 2.0

Annotation Detail for CD19


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Basic Information Top
Gene Symbol:CD19 ( B4,MGC12802 )
Gene Full Name: CD19 molecule
Band: 16p11.2
Quick LinksEntrez ID:930; OMIM: 107265; Uniprot ID:CD19_HUMAN; ENSEMBL ID: ENSG00000177455; HGNC ID: 1633
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa05340Primary immunodeficiency
hsa04662B cell receptor signaling pathway
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200005BCR signaling pathway
Pathway IDPathway Name
P00010B cell activation
Pathway IDPathway Name
500477Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1704Common variable immunodeficiency
1818Systemic scleroderma
1973Hypogammaglobulinemia
2051Leukemia
Desease Name
rheumatoid arthritis
sclerosis, systemic
systemic lupus erythematosus
IMMUNE
Crohn's disease
No data
Desease Name
Antibody deficiency due to defect in CD19
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in decreased expression of CD19 mRNAdecreases expression 19925653
D002392 Catechin Catechin results in increased expression of CD19 mRNAincreases expression 15465739
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in increased expression of CD19 proteinincreases expression 10813102
D010126 Ozone TTPA protein affects the reaction [Ozone results in decreased expression of CD19 mRNA]affects reaction|decreases expression 19555225
C006253 pirinixic acid pirinixic acid results in decreased expression of CD19 mRNAdecreases expression 17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D000361 Agammaglobulinemia marker/mechanism 16672701
MESH:D000544 Alzheimer Disease Ozone 2.5015513908
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6215570426
MESH:D001249 Asthma Ozone 2.7216373670 17854713
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9618315731 16777450 15516495 14754758 18417511 19059883 17626835
MESH:D002100 Cachexia Ozone 5.2816183385
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D017074 Common Variable Immunodeficiency marker/mechanism 16672701
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D005234 Fatty Liver pirinixic acid 3.1419236843 20131406
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4818467677 19772884 19176532 16221962
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D020138 Hyperhomocysteinemia Catechin 5.3017292331
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.8517604070
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 5.2118177683
MESH:D008113 Liver Neoplasms pirinixic acid 5.2115890375 16377806 20007298
MESH:D008171 Lung Diseases Ozone 3.608266340 19066396
MESH:D055370 Lung Injury Ozone 4.3320417186
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 3.0611696405 15390079 11246140 16337739 19359593 18597497 19925653
MESH:D008175 Lung Neoplasms Ozone 3.067614698 8597069
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 3.961500032
MESH:D008679 Metaplasia Ozone 5.7210496685
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010538 Peritonitis Ozone 4.6116369182
MESH:D011014 Pneumonia Butylated Hydroxytoluene 13.1911893704
MESH:D011014 Pneumonia Ozone 13.1918007984 18929643 18381685
MESH:D011085 Polycystic Ovary Syndrome ethinyl estradiol-desogestrel combination 5.9817105841
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D019851 Thrombophilia ethinyl estradiol-desogestrel combination 6.2311994571
MESH:D020246 Venous Thrombosis ethinyl estradiol-desogestrel combination 6.1215869587
Pathway ID Pathway Name
KEGG:04662 B cell receptor signaling pathway
KEGG:04640 Hematopoietic cell lineage
KEGG:05340 Primary immunodeficiency
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26192
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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