AutismKB 2.0

Annotation Detail for NAPRT1


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Basic Information Top
Gene Symbol:NAPRT1 ( PP3856 )
Gene Full Name: nicotinate phosphoribosyltransferase domain containing 1
Band: 8q24.3
Quick LinksEntrez ID:93100; OMIM: 611552; Uniprot ID:PNCB_HUMAN; ENSEMBL ID: ENSG00000147813; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of vitamins and cofactors
No data
No data
Pathway IDPathway Name
500872Nicotinamide salvaging
Related Diseases/Disorders Top
No data
No data
Desease Name
ADHD
PSYCH
attention-deficit hyperactivity disorder
Desease Name
Attention deficit hyperactivity disorder
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of NAPRT1 mRNAincreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NAPRT1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of NAPRT1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NAPRT1 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NAPRT1 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of NAPRT1 mRNAdecreases expression 20106945
C480543 N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide results in decreased activity of NAPRT1 proteindecreases activity 19426698
14612543
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NAPRT1 mRNAincreases expression 19933214
18796159
D014303 Trinitrotoluene Trinitrotoluene affects the expression of NAPRT1 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.5315322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 9.537525203
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8820146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.693084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6921507988 12907637 12619106
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 7.8810977129
MESH:D002386 Cataract Trinitrotoluene 7.8815817613 14694615
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6612371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Cyclosporine 3.0619486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815668235 16354765 8697196 12621046 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.8917141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 9.8915095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1118551238
MESH:D003490 Cyanosis Trinitrotoluene 12.1118551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4316109766 11461765 16781746 12540782 19739265 19416960 12705907 12153990 11421492 10774834 15968718 14550746 11287661 16485898 10915739 18071297 15619225 2444490 17906064 17562736 19085960 19923254 16227642 12594235 16177239 19370779 19420014 11739529 12958197 11743745 11834606 16393943 14725611 10663392 14986274 18713872 17522070 19164858 16081117 11529661 12392966
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.4320420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 9.4321346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Cyclosporine 3.0619224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Cyclosporine 9.3612168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3620067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7710048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.5916120746 15340226 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 9.5915817613
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006973 Hypertension Cyclosporine 5.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718670907 18850075
MESH:D007248 Infertility, Male Trinitrotoluene 3.8012150543
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.168314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8512371664
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6719014921 19784758 11587558 19460945 16610002 12969438 12587719 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.412125692 9163691 15890375 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.4120195826 21137059
MESH:D008113 Liver Neoplasms N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide 11.4114612543
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.218603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2112151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4720464547 20869020 20064080 20135361 18569708 18816296 6695378 18520028 17053015
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4719555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.6518551238
MESH:D009336 Necrosis Trinitrotoluene 11.6518551238
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2511141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.8712819281 16049721
MESH:D009784 Occupational Diseases Trinitrotoluene 9.8712819281 17852074 14694615
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811399792 11896295 11118676 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.6518551238
MESH:D012640 Seizures Trinitrotoluene 6.6518551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7619755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D013163 Splenomegaly Trinitrotoluene 5.4615817613
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2017053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:11193 Metabolism of vitamins and cofactors
KEGG:00760 Nicotinate and nicotinamide metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142671293
    • No data
    No data
    Releated drug ID Related drug Name
    PA450617niacin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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