AutismKB 2.0

Annotation Detail for ACCN3


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Basic Information Top
Gene Symbol:ACCN3 ( ASIC3,DRASIC,SLNAC1,TNaC1 )
Gene Full Name: amiloride-sensitive cation channel 3
Band: 7q35
Quick LinksEntrez ID:9311; OMIM: 611741; Uniprot ID:ACCN3_HUMAN; ENSEMBL ID: ENSG00000213199; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ACCN3 mRNAaffects expression 17562736
D000143 Acids [Acids binds to and affects the activity of ACCN3 protein] which results in increased secretion of Adenosine Triphosphateaffects activity|affects binding|increases secretion 19860742
D000255 Adenosine Triphosphate [Acids binds to and affects the activity of ACCN3 protein] which results in increased secretion of Adenosine Triphosphateaffects activity|affects binding|increases secretion 19860742
D000584 Amiloride ACCN3 protein affects the susceptibility to Amilorideaffects response to substance 12037186
D000584 Amiloride Amiloride binds to and results in decreased activity of ACCN3 proteinaffects binding|decreases activity 19860742
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACCN3 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ACCN3 mRNAdecreases expression 17805973
D005620 Freund's Adjuvant Freund's Adjuvant results in increased expression of ACCN3 mRNAincreases expression 16769263
D005682 Gadolinium Gadolinium binds to and results in decreased activity of ACCN3 proteinaffects binding|decreases activity 19860742
C035988 procymidone procymidone results in decreased expression of ACCN3 mRNAdecreases expression 15686871
C017953 tetramethylpyrazine tetramethylpyrazine results in increased expression of ACCN3 mRNAincreases expression 15520497
C025643 vinclozolin vinclozolin results in decreased expression of ACCN3 mRNAdecreases expression 15686871
D015054 Zymosan ACCN3 protein affects the susceptibility to Zymosanaffects response to substance 17553498
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000740 Anemia Zymosan 4.6618664788
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7319015723
MESH:D001169 Arthritis, Experimental Zymosan 4.1915188379 16872482 17659584 15944321 15142272
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001862 Bone Resorption Freund's Adjuvant 5.2416769263
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9216227642 10355542 15673190 3786805 16050911 16124888 16192424 16011737 15721981 16097048 15700767 18705752
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.893084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.8918788625
MESH:D002295 Carcinoma, Transitional Cell Amiloride 5.1814644129
MESH:D002386 Cataract Acetaminophen 7.9910977129
MESH:D002386 Cataract Adenosine Triphosphate 7.9915003327
MESH:D002637 Chest Pain Acids 6.5815447763
MESH:D003092 Colitis Amiloride 5.2412065299
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8415619225 10915739 10663392 12705907 16485898 11287661 11529661 11461765 12392966 18713872 19420014 11739529 16393943 16109766 12153990 11743745 10774834 18071297 12540782 14725611 17562736 16781746 14550746 17906064 19370779 19416960 19085960 19739265 15968718 19164858 14986274 19923254 16081117 17522070 16177239 12594235 11421492 12958197 16227642 11834606 2444490
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.847440962 6884620 16227642 7179309 17522070 10915739 16177239 21278145 9327722 15027814 19336974 3732212 4309450 15998439 15968718 10092053 11566570 3786805 2869522 7120509 19085960 6623471
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004487 Edema Zymosan 4.097907874
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.2812631006 19224547 12795759 16045604 16239168 61145 15959796 17595544
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5918705752
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D006130 Growth Disorders Amiloride 4.8219703807
MESH:D006505 Hepatitis Carbon Tetrachloride 10.0919900420 19110552
MESH:D006505 Hepatitis Zymosan 10.0919110552
MESH:D006930 Hyperalgesia Acetaminophen 8.4616870215
MESH:D006930 Hyperalgesia Freund's Adjuvant 8.4616769263
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006973 Hypertension Amiloride 3.9119344079 18524855 15174897
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D020514 Hypokalemic Periodic Paralysis Amiloride 6.0019822448
MESH:D007248 Infertility, Male vinclozolin 3.1116467254
MESH:D007249 Inflammation Amiloride 9.2017237260
MESH:D007249 Inflammation Freund's Adjuvant 9.2016793879
MESH:D007249 Inflammation Zymosan 9.208014878 11289658
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.9917553498
MESH:D007673 Kidney Cortex Necrosis tetramethylpyrazine 6.8918842672
MESH:D007674 Kidney Diseases Acetaminophen 2.2612587719 15629191
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D056929 Liddle Syndrome Amiloride 6.1119344079
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8616239168 17334410 16221502 11408273 17157831 21278145 16943688 17174718 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7515730626 15650968 18156304 18472332 12741479 16097048 17565644 15893842 15123356 14724832 18412020 15052691 13678700 17976157 15996030 18263696 12586293 14716833 18279442 14748882 12632514 18420326 17805973 17944888 12958196 18317297 15876570 15057751 15362042 18705752 17557913 15959796 12445421 16033810 15338365 18277467 18395914 20821823 18418968 18395095 17640975 12609069 17766677 16116963 12667390 16011737 17525996 16015684 18481824 17900296 18187930 11481614 12898905 15925388 16027843 17922224 18429990 16638106 18166357 17869086 18205269 16136751 15673190 17698563 17721639 17761835 12632512 15818738 17631135 12389079 16192424 18472094 12546737 17708605 10355542 15370692 18339082 14512876 16248980 17823541 18210741 12666154 17481882 12445418 15931870 14716496 12649538 18054572 17714472 18376398 18251166 18006644 14620537
MESH:D008107 Liver Diseases Acetaminophen 3.9816610002 12969438 19784758 16611625 19460945 12587719 19014921 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9815830285 16246199 17285989 16964402 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.7616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.7614706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.2619294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6812014681 15583823
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D009102 Multiple Organ Failure Zymosan 5.3118160304 10479408 12130978 15213630 12879239 15259001 15834315 17724436 10890648 15241586
MESH:D009361 Neoplasm Invasiveness Amiloride 5.4314644129
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010538 Peritonitis Zymosan 5.0219641140 18760300 17826846 17371808 18977430 11985352 15979727 14761945 19088179 15259001 18557954
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0518042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D018805 Sepsis Zymosan 4.7411441115
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014605 Uveitis Zymosan 5.5711006244
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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