AutismKB 2.0

Annotation Detail for TRIP13


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Basic Information Top
Gene Symbol:TRIP13 ( 16E1BP )
Gene Full Name: thyroid hormone receptor interactor 13
Band: 5p15.33
Quick LinksEntrez ID:9319; OMIM: 604507; Uniprot ID:TRP13_HUMAN; ENSEMBL ID: ENSG00000071539; HGNC ID: 12307
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TRIP13 mRNAincreases expression 17547211
D000082 Acetaminophen Acetaminophen affects the expression of TRIP13 mRNAaffects expression 17562736
C014949 acetylhydrazine acetylhydrazine results in decreased expression of TRIP13 mRNAdecreases expression 15282401
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TRIP13 proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in increased expression of TRIP13 mRNAincreases expression 17547211
C015001 arsenite arsenite results in decreased expression of TRIP13 mRNAdecreases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TRIP13 mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TRIP13 mRNAdecreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of TRIP13 mRNAincreases expression 16474171
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TRIP13 mRNAaffects expression 17484886
D002945 Cisplatin TRIP13 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TRIP13 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TRIP13 mRNA]decreases reaction|increases expression 17854601
D004958 Estradiol Estradiol results in increased expression of TRIP13 mRNAincreases expression 16474171
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TRIP13 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRIP13 mRNAaffects cotreatment|increases expression 17942748
D019833 Genistein Genistein results in increased expression of TRIP13 mRNAincreases expression 16474171
D008628 Mercury Mercury results in increased expression of TRIP13 mRNAincreases expression 17547211
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of TRIP13 mRNAincreases expression 20713471
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TRIP13 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of TRIP13 mRNAincreases expression 18445702
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of TRIP13 mRNAincreases expression 16474171
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRIP13 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TRIP13 mRNAincreases expression 19465110
D014635 Valproic Acid Valproic Acid results in decreased expression of TRIP13 mRNAdecreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.9514514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8319490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8417505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.8615814532 17670903 12690470
MESH:D055371 Acute Lung Injury pirinixic acid 3.0118653653
MESH:D000230 Adenocarcinoma arsenic trioxide 16.7711798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 16.7720127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 16.7717638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 16.7711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 16.7714692618
MESH:D000230 Adenocarcinoma Genistein 16.7711473722
MESH:D000236 Adenoma Benzo(a)pyrene 10.866695378
MESH:D000236 Adenoma Diethylnitrosamine 10.866695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 10.866695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.6516434500 19052882 19061943 18056438 17162532 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.6516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.6516835633
MESH:D000550 Amblyopia Valproic Acid 5.1317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.4817497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9619183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6015885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.3911922910
MESH:D001321 Autistic Disorder Acetaminophen 2.1918445737
MESH:D001321 Autistic Disorder Mercury 2.1917497416
MESH:D001321 Autistic Disorder Valproic Acid 2.1918558336 17507914 20603192 17688650 18985861 18177632 15238991 16609825 18940202 18396377 18775368 18316065 17157402 19232924 19460635
MESH:D001327 Autoimmune Diseases Mercury 4.7616634805
MESH:D001714 Bipolar Disorder Valproic Acid 3.0217594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.6916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.6919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.6912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.7915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.798888407
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.7814601052
MESH:D001862 Bone Resorption bisphenol A 3.7611985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.6520146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 4.6517123778
MESH:D001943 Breast Neoplasms Cisplatin 4.6519526202 18382427
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.6517474063
MESH:D001943 Breast Neoplasms Estradiol 4.6517261762 16675129 17018787 17289903 14630087 12948864 19861407 18497071
MESH:D001943 Breast Neoplasms Genistein 4.6517200150 16541309 16873071
MESH:D001943 Breast Neoplasms Methylcholanthrene 4.6517474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6520435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2211589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6716227642 10355542 16192424 16011737 16050911 16124888 15721981 16097048 15673190 3786805 15700767 18705752
MESH:D002277 Carcinoma Methylcholanthrene 8.0410545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.0416835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.643084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.6412619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.6414691202 11135700 15073043 16217749 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.6418788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 16.6417982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.6417978847 10737359 20007298 18691550 21159647 20512989 16878318 16540662 16328049 18978308 16288022 19919837 17761372 16830150 20727157 16681979 19208518 18056438 19335982 17162532 18785209 20432363 16779866 18971187 16502159 19418558 20084675 18665156 19171122 20214788 11831363 19383236 17173139 19107877 17428255 18494052 20524982 17055752 16807293 16935385 3581430 10672840 20935162 16698587 19052882 20101231 20514400 16569478 17138121 18506893 19519916 19822196 18210153 19539802 19394651 19701751 3084413 18393292 18788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.6416924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 16.6416924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.8817123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0012023789 16685392
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7719014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6620419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 4.6618337622 17066447 6189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.4210334427
MESH:D002318 Cardiovascular Diseases Genistein 3.2316332659
MESH:D002386 Cataract Acetaminophen 2.5210977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.4320889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.4317174075 2727394 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.4318566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 15.4316192471
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6720734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.0119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.4716105132 15861022 16919318 17333356 17681005 11677210 17110522
MESH:D002779 Cholestasis pirinixic acid 7.4719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0616354765 15668235 8697196 15340226 12621046
MESH:D003110 Colonic Neoplasms arsenite 3.9115037631
MESH:D003110 Colonic Neoplasms Genistein 3.9117182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.5520501625
MESH:D015179 Colorectal Neoplasms Cisplatin 3.5515273666
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 3.5515531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9614669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7010048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.7016575769 17688650 8888407
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9915213294
MESH:D003704 Dementia Polychlorinated Biphenyls 4.6016140633
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.6916823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.9520387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.9516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.9517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3219279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.6619164858 12153990 11421492 14725611 11529661 10915739 12392966 17906064 16109766 16781746 16393943 11287661 16227642 12705907 16177239 19739265 16081117 18071297 14550746 11461765 19370779 19416960 2444490 18713872 16485898 15619225 19085960 11739529 14986274 12958197 12594235 17522070 19923254 19420014 11834606 12540782 10774834 11743745 10663392 15968718 17562736
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.669327722 7120509 15968718 10915739 4309450 10092053 19085960 2869522 7440962 3732212 6623471 21278145 11566570 19336974 16227642 3786805 17522070 7179309 15998439 15027814 16177239 6884620
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.6619107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.6620420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.661733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004362 Drug Toxicity Cisplatin 7.9112231392 15033597 12649298 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.9111462148
MESH:D004421 Dystonia Valproic Acid 3.941851702
MESH:D004487 Edema pirinixic acid 6.2012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8018230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0812538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.4816402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.2718566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Genistein 7.2711473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.0417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.813922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8818234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.497562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.197750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.963659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0116302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.1820426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.1812903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.1816530937
MESH:D004938 Esophageal Neoplasms Cisplatin 10.1816785472 16481741 15464296 15173087 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005234 Fatty Liver arsenic trioxide 35.4515073043
MESH:D005234 Fatty Liver arsenite 35.4518296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 35.4515959796 12795759 16045604 12631006 61145 16239168 19224547 17595544
MESH:D005234 Fatty Liver Diethylnitrosamine 35.4521071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 35.4515345470
MESH:D005234 Fatty Liver pirinixic acid 35.4519236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 35.4519224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.028888407 18558336
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.8310962813 14633661
MESH:D005355 Fibrosis arsenite 14.2018296743
MESH:D005355 Fibrosis Carbon Tetrachloride 14.2018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.2020067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1516904648
MESH:D005756 Gastritis Acetaminophen 3.5716983495
MESH:D005909 Glioblastoma Genistein 3.1916598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.6415464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.2019898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3315464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2611294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4919900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.9019176532 18467677 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.9012621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.9315709030
MESH:D006689 Hodgkin Disease Cisplatin 3.5016170182 16200630
MESH:D019584 Hot Flashes Estradiol 3.6517088409
MESH:D006849 Hydrocephalus Valproic Acid 4.7617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9415340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.6116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4216899240
MESH:D006943 Hyperglycemia pirinixic acid 3.0820558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8718850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9815338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7016569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4117937319
MESH:D007249 Inflammation Diethylnitrosamine 4.7118785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.7112878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 11.9016393666
MESH:D007333 Insulin Resistance Estradiol 11.9016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.9016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.0315464296
MESH:D007674 Kidney Diseases Acetaminophen 13.9812587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 13.9815190930 18289764 12649298 19839026 12231392
MESH:D007674 Kidney Diseases Estradiol 13.9815618244
MESH:D007674 Kidney Diseases Mercury 13.9817934191
MESH:D007680 Kidney Neoplasms Estradiol 2.8915610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.6911231351
MESH:D007938 Leukemia arsenic trioxide 6.2515070760
MESH:D007938 Leukemia Genistein 6.2518980019 17468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6917077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6619077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8417050201 20471514 19850784 16968895 16467208
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8417596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1416823087 16330433 15622746 17712046 19075265 17107899 16891316 19642359 17649720 15336539 15213294 9834237 11161223 11468182 15748426 12018890 16331271 12679006 19225113 19035177 16966277 12712474 17217047 16112521 17869043
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2416882451
MESH:D008103 Liver Cirrhosis arsenite 10.7418296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.7417334410 11903743 16239168 17174718 11408273 16943688 21278145 17157831 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.7420032147 19638242 18522880 18407596 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5817721639 16015684 17766677 12445418 16192424 18705752 15338365 12389079 15996030 17708605 12632514 14620537 18205269 15057751 18418968 12609069 15362042 18420326 12586293 14512876 18429990 15370692 17525996 12666154 12741479 17565644 17631135 18395095 15673190 17823541 15730626 18166357 12445421 15052691 13678700 14716496 15123356 16011737 18339082 17557913 17805973 16033810 18187930 18263696 10355542 15925388 16248980 18472332 12667390 15931870 18156304 15893842 15876570 16638106 16027843 17698563 12632512 18472094 18210741 18317297 18279442 17922224 12958196 17761835 17640975 16136751 14748882 17481882 15818738 14724832 15959796 12649538 16097048 17944888 17714472 18412020 12546737 12898905 18054572 16116963 18481824 18006644 14716833 17900296 17976157 18376398 17869086 18251166 20821823 11481614 18395914 18277467 15650968
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.5817823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5812878042
MESH:D008107 Liver Diseases Acetaminophen 6.3011587558 12969438 19784758 16611625 16610002 12587719 19014921 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.3016964402 16246199 15830285 15720792 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 6.3017034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.0816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.0816899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 21.2818177683 15890375 9163691 2125692
MESH:D008113 Liver Neoplasms arsenic trioxide 21.2814682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.2820195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.2819294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.2820501860 19690152 20118626 20492335 20583210 19812893 19642983 19254457 18977376 19426721 21071580 12771043 20434301 19427195 19551842 12112319 18978307 19833225 19090486 20101389 2862719 19073162 19255062 21278145 19850985 18648771 15885732 10737359 21167192 19499222 2422723 19638242 19996281 18754104 19256749 21047994 20405173 19294768 20137499 9163691 18644402 16942905 20452335 15175105
MESH:D008113 Liver Neoplasms pirinixic acid 21.2816377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.2816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 27.248603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 27.2420377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 27.2412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 27.2418308698 18079962 2563599 18544905 18282651 3124819 9362446 16267830 19004024 18253720 16842330 18164116 21159647 19126423 17854601 17942915 17174075 18775883 19519916 18093689 19009564 19539802
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 27.24598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 27.241423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 27.2412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2615213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1617228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 12.7814755239
MESH:D008175 Lung Neoplasms arsenic trioxide 12.7811798837 19825857
MESH:D008175 Lung Neoplasms arsenite 12.7816809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.7818569708 20464547 20064080 17053015 20135361 18520028 18816296 20869020 6695378
MESH:D008175 Lung Neoplasms Cisplatin 12.7811798837 6189445 17225452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.7820512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Methylcholanthrene 12.7820970405 16337739 16271038 9230183 11893704 15390079 10545420 1399818 7750092 21163286 17909032 20512841 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.7811884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.8511807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 5.8512929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 4.3819453300
MESH:D008545 Melanoma Cisplatin 2.4611135225 18505091 12374674 16809738 16248763 18176117 17761969 15577323 12393984 16432458 12883367 17023156 18332650
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.6715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D008654 Mesothelioma Cisplatin 3.2017638057
MESH:D008881 Migraine Disorders Valproic Acid 3.1118765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0315949261 14977855 19417148 19549372 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.928888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.2116882451 16105982
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.2117596541
MESH:D009203 Myocardial Infarction Genistein 5.5317141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.5319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.6816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.6817141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.6816411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8516624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.523581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 7.9511141357
MESH:D009369 Neoplasms Cisplatin 7.9516773208
MESH:D009369 Neoplasms pirinixic acid 7.9517405874
MESH:D009389 Neovascularization, Pathologic arsenite 9.7915738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.7917289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.3915464296
MESH:D009421 Nervous System Malformations bisphenol A 22.5716427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 22.5711399458 16427766
MESH:D009421 Nervous System Malformations Genistein 22.5716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 22.5714600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.0910525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.0916359493 8888407
MESH:D009447 Neuroblastoma Cisplatin 3.398761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.8820387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.598761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0120387270
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D010024 Osteoporosis Genistein 3.1819401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9816169203
MESH:D010049 Ovarian Diseases bisphenol A 4.8811985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.0419769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Cisplatin 11.0415464296 19769630 17225452 6897625
MESH:D010051 Ovarian Neoplasms Estradiol 11.0419401270
MESH:D010051 Ovarian Neoplasms Genistein 11.0419005980
MESH:D010146 Pain Acetaminophen 2.3016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.4615580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 8.4619003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.4616540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5811578682
MESH:D010235 Paraganglioma arsenic trioxide 4.0619927285
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3516702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2015464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.2417638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.462563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 15.6210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.6211222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 15.6220603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.2120887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.2120887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8919131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8916740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8916925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 1.8915721890
MESH:D011537 Pruritus Ethinyl Estradiol 3.2016919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.4411422049 12752131
MESH:D011629 Puberty, Precocious bisphenol A 4.6810548101
MESH:D051437 Renal Insufficiency Cisplatin 4.3015464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.3319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0719155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.9916646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.9914601052
MESH:D012559 Schizophrenia Valproic Acid 2.0515737665 19110320
MESH:D012640 Seizures Valproic Acid 2.6616876388 17978042 11044598 15475178 14763951 11738929 3137016 1511512
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.3019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3016192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.2415464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8416709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4412833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.6417007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.642093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 4.6417522103 15958060 18396642
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.6418456281
MESH:D019966 Substance-Related Disorders bisphenol A 3.8816045194 16684133
MESH:D013736 Testicular Neoplasms Cisplatin 4.5315464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.9119014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.917505956
MESH:D013978 Tibial Fractures Estradiol 4.5819048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8515213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.1317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.413119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.1311780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.1317053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.1315464296 12973940 17225452
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.538888407
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.1116803524
MESH:D014591 Uterine Diseases bisphenol A 4.9014652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1914692618
MESH:D014625 Vaginal Neoplasms Cisplatin 4.5015577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4414671159 15869587
MESH:D014839 Vomiting Cisplatin 4.6111897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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