AutismKB 2.0

Annotation Detail for TRIP4


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Basic Information Top
Gene Symbol:TRIP4 ( ASC-1,HsT17391 )
Gene Full Name: thyroid hormone receptor interactor 4
Band: 15q22.31
Quick LinksEntrez ID:9325; OMIM: 604501; Uniprot ID:TRIP4_HUMAN; ENSEMBL ID: ENSG00000103671; HGNC ID: 12310
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of TRIP4 mRNAincreases expression 18648102
D016572 Cyclosporine Cyclosporine results in increased expression of TRIP4 mRNAincreases expression 20106945
D008713 Methimazole Methimazole results in decreased expression of TRIP4 mRNAdecreases expression 17403546
C494474 perchlorate perchlorate results in decreased expression of TRIP4 mRNAdecreases expression 17403546
C006253 pirinixic acid pirinixic acid results in decreased expression of TRIP4 mRNAdecreases expression 18445702
D011441 Propylthiouracil Propylthiouracil results in decreased expression of TRIP4 mRNAdecreases expression 17403546
C025462 sulindac sulfide sulindac sulfide results in increased expression of TRIP4 mRNAincreases expression 16184548
D013974 Thyroxine Thyroxine results in increased expression of TRIP4 mRNAincreases expression 17403546
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000544 Alzheimer Disease sulindac sulfide 3.1318759972
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.0419483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 10.0419483382
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.773581430 7296757
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.5112391285
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D006332 Cardiomegaly Thyroxine 4.2218093424
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.107505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1012371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.429022650 19486331
MESH:D002779 Cholestasis Cyclosporine 14.4219486331
MESH:D002779 Cholestasis pirinixic acid 14.4219176532
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1018759878 12868966 11906362 2524372 11298694 8970840 14531868 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0118692083 7440962 11289319 1440618 6482804 6679447 18648102 16192314 8291058 9328219 18289764 9022650 9653073
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Cyclosporine 8.3819224547
MESH:D005234 Fatty Liver pirinixic acid 8.3820131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Cyclosporine 3.4512168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 12.367505956
MESH:D006042 Goiter perchlorate 12.3618801409
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 18467677 19176532 19772884
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D006980 Hyperthyroidism Methimazole 5.9014678291
MESH:D007037 Hypothyroidism Methimazole 13.0018031379
MESH:D007037 Hypothyroidism Propylthiouracil 13.008137927 18031379
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.409022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4618776723 8314463 10903974
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.956582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.8916377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.671399818 6587162 598648 3712494
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.654026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D013959 Thyroid Diseases Thyroxine 6.0219910387
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.991399818 3712494 6582329 7505956 6587162
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.9915710170
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.358074119
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.9318645019
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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