AutismKB 2.0

Annotation Detail for CD22


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Basic Information Top
Gene Symbol:CD22 ( FLJ22814,MGC130020,SIGLEC-2,SIGLEC2 )
Gene Full Name: CD22 molecule
Band: 19q13.12
Quick LinksEntrez ID:933; OMIM: 107266; Uniprot ID:CD22_HUMAN; ENSEMBL ID: ENSG00000012124; HGNC ID: 1643
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa04514Cell adhesion molecules (CAMs)
hsa04662B cell receptor signaling pathway
No data
Pathway IDPathway Name
200005BCR signaling pathway
Pathway IDPathway Name
P00010B cell activation
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
Desease Name
sclerosis, systemic
systemic lupus erythematosus
IMMUNE
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of CD22 mRNAincreases expression 20458559
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD22 mRNAaffects cotreatment|increases expression 17942748
C011890 kojic acid kojic acid results in decreased expression of CD22 mRNAdecreases expression 16595896
D009151 Mustard Gas Mustard Gas results in increased expression of CD22 mRNAincreases expression 15674843
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD22 mRNAaffects cotreatment|increases expression 17942748
D015032 Zinc Zinc results in increased expression of CD22 mRNAincreases expression 15226459
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of CD22 mRNAincreases expression 15226459
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 11752688 14514962
MESH:D000138 Acidosis Zinc Sulfate 5.307265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000169 Acrodermatitis Zinc 5.8016889938 17190629 17202136
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4819825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4814692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000544 Alzheimer Disease Zinc 2.8016325427 16580781 16410023 17119284
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000755 Anemia, Sickle Cell Zinc 5.2316916123
MESH:D000860 Anoxia Zinc Sulfate 5.417265320
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001249 Asthma Mustard Gas 5.4410378619
MESH:D001249 Asthma Zinc 5.4417085522
MESH:D001768 Blister Mustard Gas 5.5619167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.9216206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.9212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001930 Brain Injuries Zinc 5.0517109824
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.4217687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9714691202 15553829 11135700 15073043 16217749
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002294 Carcinoma, Squamous Cell Zinc 2.9616543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.8416936243
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717681005 15861022 16919318 17110522 11677210 17333356 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015668235 8697196 12621046 15340226 16354765
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.9710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9710048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Zinc 3.9719302082
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003920 Diabetes Mellitus Zinc 4.4516479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Mustard Gas 7.7911402378 9260866 11428647 11428631
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.7912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004890 Erythema Mustard Gas 5.569357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.9412903497
MESH:D004938 Esophageal Neoplasms Zinc 4.9416543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver arsenic trioxide 8.6915073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005756 Gastritis Zinc 5.2417241300
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006130 Growth Disorders Zinc 4.1317217573
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006333 Heart Failure Zinc 3.7617162251
MESH:D006335 Heart Injuries Zinc 6.2117074742
MESH:D016481 Helicobacter Infections Zinc 4.8417241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006527 Hepatolenticular Degeneration Zinc 12.5417276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 12.5417063115
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2512621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916959395 18606429 8697196 15340226 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D007022 Hypotension Zinc Sulfate 4.777265320
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Mustard Gas 5.488975870 9357497 11428620 11428631 9260866 11428647 17524151 16001271 11402378
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4812200463 12878042
MESH:D007511 Ischemia Zinc 4.9916584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Zinc 3.4616960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.7016518626
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.5015237267
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1720471514 17050201 16467208 16968895 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3819035177 15748426 19642359 17869043 16823087 17217047 17107899 17712046 17649720 15622746 11468182 12018890 12712474 16331271 16112521 16330433 15213294 9834237 19075265 15336539 16891316 12679006 19225113 16966277 11161223
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms arsenic trioxide 4.7314682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7316984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.8620377131
MESH:D008114 Liver Neoplasms, Experimental kojic acid 10.8618544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.8612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008171 Lung Diseases Mustard Gas 3.6218161513 18702808
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5811798837 19825857
MESH:D008175 Lung Neoplasms Mustard Gas 3.588781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5819555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.4612773700
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2914977855 19549372 19417148 11468182 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2810525206
MESH:D009503 Neutropenia Mustard Gas 4.2716761898 7688884
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4719769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D011041 Poisoning Mustard Gas 4.1015727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011225 Pre-Eclampsia Zinc 4.3917114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.4319131511
MESH:D011471 Prostatic Neoplasms Zinc 3.4316517595 12429649 16700911 16606632
MESH:D011537 Pruritus Ethinyl Estradiol 10.8815861022 16919318
MESH:D011537 Pruritus Mustard Gas 10.8818058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0117720292 17266442 17620002 17894541 10334151
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012162 Retinal Degeneration Zinc 4.3316584753
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012871 Skin Diseases Mustard Gas 2.7712880345 15451306 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2919014326
MESH:D014062 Tongue Neoplasms Zinc 4.6616543248
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5720435036 12845720 12973940 11780464
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
Pathway ID Pathway Name
KEGG:04662 B cell receptor signaling pathway
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:04640 Hematopoietic cell lineage
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26201
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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