AutismKB 2.0

Annotation Detail for CD163


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Basic Information Top
Gene Symbol:CD163 ( M130,MM130 )
Gene Full Name: CD163 molecule
Band: 12p13.31
Quick LinksEntrez ID:9332; OMIM: 605545; Uniprot ID:C163A_HUMAN; ENSEMBL ID: ENSG00000177575; HGNC ID: 1631
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1809HIV infection
1835Leiomyosarcoma
1902Kidney failure
1904Diabetes mellitus
1997Dental plaque
2076Spondylarthropathies
2111Systemic infection
2208Synovitis
No data
Desease Name
Hematological and biochemical traits
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CD163 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CD163 mRNAdecreases expression 20064835
D002794 Choline Choline affects the expression of CD163 mRNAaffects expression 17616785
D003907 Dexamethasone Dexamethasone results in increased expression of CD163 proteinincreases expression 17410599
D004041 Dietary Fats Dietary Fats results in decreased expression of CD163 mRNAdecreases expression 18042831
D010126 Ozone Ozone results in increased expression of CD163 mRNAincreases expression 17095637
C041786 palm oil palm oil results in decreased expression of CD163 mRNAdecreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of CD163 mRNAincreases expression 17560707
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CD163 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of CD163 mRNAdecreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CD163 mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.686195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.9317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.9316434500
MESH:D000544 Alzheimer Disease Ozone 2.4715513908
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001169 Arthritis, Experimental Dexamethasone 3.6417659584
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5915570426
MESH:D001249 Asthma Ozone 2.6816373670 17854713
MESH:D001321 Autistic Disorder Acetaminophen 2.3518445737
MESH:D001321 Autistic Disorder Choline 2.3516818868
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0920146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.0920435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8114754758 15516495 16777450 18315731 18417511 19059883 17626835
MESH:D002100 Cachexia Ozone 4.9816183385
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.943084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.941701930 17173139 20007298 6705139 20935162
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D002340 Carotid Artery Diseases marker/mechanism 17095719
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.474080065
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5215824018
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.2917728286
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.6112438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D002658 Developmental Disabilities Choline 4.7816818868
MESH:D003967 Diarrhea Dexamethasone 3.897237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6311287661 15968718 19739265 19085960 11421492 16109766 12705907 12392966 12153990 16227642 14986274 11834606 10915739 19420014 19416960 16177239 17906064 16081117 11529661 10774834 11461765 17562736 14725611 15619225 16781746 19370779 17522070 2444490 12958197 19923254 14550746 16393943 18071297 18713872 12540782 12594235 10663392 11739529 11743745 19164858 16485898
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004421 Dystonia Phenobarbital 4.191851702
MESH:D004485 Eczema Dexamethasone 4.6612438553
MESH:D004487 Edema Dexamethasone 12.6219703484
MESH:D004487 Edema perfluorooctanoic acid 12.6212083418 17259670
MESH:D004487 Edema pirinixic acid 12.6212083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.323659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.143922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.696401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.263659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005234 Fatty Liver Dietary Fats 8.2819551842 17967931 18296743 19004024
MESH:D005234 Fatty Liver pirinixic acid 8.2820131406 19236843
MESH:D005355 Fibrosis Dietary Fats 3.7418296743
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7420471113
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006529 Hepatomegaly perfluorooctanoic acid 15.853609246
MESH:D006529 Hepatomegaly Phenobarbital 15.8516109766
MESH:D006529 Hepatomegaly pirinixic acid 15.8518467677 16221962 19772884 19176532
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.127520565
MESH:D006930 Hyperalgesia Acetaminophen 8.3216870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 8.3212083418
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006973 Hypertension Dexamethasone 2.9917042910
MESH:D007249 Inflammation Dexamethasone 9.0011099482 8960868
MESH:D007249 Inflammation Dietary Fats 9.0020412841
MESH:D007249 Inflammation perfluorooctanoic acid 9.0012083418
MESH:D007333 Insulin Resistance Dietary Fats 7.6118457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.6116306350
MESH:D007674 Kidney Diseases Acetaminophen 2.2912587719 15629191
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.478812269
MESH:D008103 Liver Cirrhosis Dietary Fats 6.9518296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.9521047994
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.5616718785
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5615474484
MESH:D008107 Liver Diseases Acetaminophen 4.0619014921 16611625 19460945 11587558 12969438 12587719 19784758 16610002
MESH:D008107 Liver Diseases Phenobarbital 4.0619363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.2121137059 20195826
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 11.2118709148 14757943
MESH:D008113 Liver Neoplasms Phenobarbital 11.2119073162 21047994 15975961 19482888 19812893 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 11.2116377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.801399818 2563599 18308698 6150874 17172636
MESH:D008171 Lung Diseases Ozone 3.4919066396 8266340
MESH:D055370 Lung Injury Ozone 4.0620417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6220135361 18569708 17053015 18816296 18520028 20869020 6695378 20064080 20464547
MESH:D008175 Lung Neoplasms Dexamethasone 3.6211195469 15824018
MESH:D008175 Lung Neoplasms Ozone 3.628597069 7614698
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008679 Metaplasia Ozone 5.3710496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009101 Multiple Myeloma Dexamethasone 3.6215867202 16118317 15744524
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.639809623
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7117484760
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0811141357
MESH:D009369 Neoplasms pirinixic acid 5.0817405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.179802331
MESH:D009765 Obesity Dietary Fats 4.5616723640 17217161 20518802 21332399 11836018 18674790 18457598 19632207 20132043
MESH:D009765 Obesity pirinixic acid 4.5620558911
MESH:D010018 Osteomalacia Phenobarbital 4.6017016548
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5416965848
MESH:D010538 Peritonitis Ozone 4.3516369182
MESH:D011014 Pneumonia Ozone 4.6318381685 18929643 18007984
MESH:D011230 Precancerous Conditions Phenobarbital 3.772563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6321297632
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.6317132714
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D019310 Pseudolymphoma Phenobarbital 4.7612752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.2011700416 18379247
MESH:D012640 Seizures Phenobarbital 2.8011442880 16876388 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.066407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4419755658 10029692
MESH:D013272 Stomach Diseases Dexamethasone 4.5615472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer Dexamethasone 3.6515138204
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.181399818
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2317053015
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Dexamethasone 5.081336536
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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