AutismKB 2.0

Annotation Detail for SNAP29


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Basic Information Top
Gene Symbol:SNAP29 ( CEDNIK,FLJ21051,SNAP-29 )
Gene Full Name: synaptosomal-associated protein, 29kDa
Band: 22q11.21
Quick LinksEntrez ID:9342; OMIM: 604202; Uniprot ID:SNP29_HUMAN; ENSEMBL ID: ENSG00000099940; HGNC ID: 11133
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04130SNARE interactions in vesicular transport
No data
No data
Pathway IDPathway Name
P04378Beta2 adrenergic receptor signaling pathway
P00039Metabotropic glutamate receptor group III pathway
P04391Oxytocin receptor mediated signaling pathway
P04379Beta3 adrenergic receptor signaling pathway
P00001Adrenaline and noradrenaline biosynthesis
P04377Beta1 adrenergic receptor signaling pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00044Nicotinic acetylcholine receptor signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P043745HT2 type receptor mediated signaling pathway
P00037Ionotropic glutamate receptor pathway
P04380Cortocotropin releasing factor receptor signaling pathway
P00040Metabotropic glutamate receptor group II pathway
P043765HT4 type receptor mediated signaling pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P043755HT3 type receptor mediated signaling pathway
P043735HT1 type receptor mediated signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1990Skin disease, Genetic
1763Keratosis
1791Neuropathy
2194Palmoplantar keratosis
2236Cardiovascular disease
Desease Name
PSYCH
schizophrenia
No data
Desease Name
Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SNAP29 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SNAP29 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SNAP29 mRNAaffects expression 16483693
D002945 Cisplatin Cisplatin results in increased expression of SNAP29 proteinincreases expression 16803524
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SNAP29 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil results in increased expression of SNAP29 proteinincreases expression 16803524
C006253 pirinixic acid pirinixic acid results in increased expression of SNAP29 mRNAincreases expression 18301758
C004648 testosterone enanthate testosterone enanthate affects the expression of SNAP29 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SNAP29 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D058186 Acute Kidney Injury Cisplatin 4.1612690470 17670903 15814532
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Cisplatin 7.4211798837 17638652
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.4214692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.4217638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000740 Anemia Fluorouracil 9.3317963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.3311748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.2014601052
MESH:D001943 Breast Neoplasms Cisplatin 1.9318382427 19526202
MESH:D001943 Breast Neoplasms Fluorouracil 1.9315136595 16110121 19217205 16557594 18608205 16595493 18357371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9916051944
MESH:D002277 Carcinoma Fluorouracil 8.7417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.8417982673
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.8417971768 16799960 18930000 16332177 17088986 17045692
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0916685392 12023789
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1018695887
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.0918337622 6189445 17066447
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 5.0916757204 17066447 18986760 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.906135515
MESH:C537943 Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome marker/mechanism
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2511677210 17333356 17681005 17110522 16919318 15861022 16105132
MESH:D002779 Cholestasis pirinixic acid 8.2519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1812621046 8697196 15668235 16354765 15340226
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2617169374 17725105 18772588 17172411 16510598 17016597 16340194 17287894 15001691 17018589
MESH:D015179 Colorectal Neoplasms Cisplatin 2.7615273666
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7618288408 15289873 18949393 18383874 16391804 16303861 18448328 16331619 17255274 18509181 20501625 17454858 17594712 18802399 16282729 14970324 17016601 17401013 17094418 17695437 16524972 15148649
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4718551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4720420201
MESH:D004362 Drug Toxicity Cisplatin 8.6819839026 15033597 12649298 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.6811462148
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004938 Esophageal Neoplasms Cisplatin 4.9215464296 16481741 17638652 16785472 15173087
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.9216481741 16785472 16337965 15173087 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.2415345470
MESH:D005234 Fatty Liver pirinixic acid 8.2419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 8.4315102660 15464296
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.4315102660 18337622 15162350
MESH:D034381 Hearing Loss Cisplatin 4.4819898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5915464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly pirinixic acid 9.1416221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1415340226 16120746 12621046
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0617440010
MESH:D006689 Hodgkin Disease Cisplatin 3.7716200630 16170182
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 8697196 18606429 16354765 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.4615464296
MESH:D007674 Kidney Diseases Cisplatin 3.3512649298 18289764 12231392 15190930 19839026
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.4716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.4716705839
MESH:D007680 Kidney Neoplasms Fluorouracil 13.4716985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.1111231351
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1912878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.257678174
MESH:D008113 Liver Neoplasms Fluorouracil 11.2517045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 11.2515890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.146135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1412151625
MESH:D008175 Lung Neoplasms Cisplatin 3.5917225452 11798837 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 3.5915246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5911884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D008545 Melanoma Cisplatin 2.4916809738 18332650 18505091 16248763 17023156 11135225 16432458 12883367 15577323 18176117 12393984 12374674 17761969
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.0615990972
MESH:D008654 Mesothelioma Cisplatin 3.3117638057
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7918986760 16757204
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.327678174 18551238
MESH:D009369 Neoplasms Cisplatin 8.8716773208
MESH:D009369 Neoplasms Fluorouracil 8.8718239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 8.8717405874
MESH:D009395 Nephritis, Interstitial Cisplatin 4.8115464296
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009447 Neuroblastoma Cisplatin 3.548761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.988761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D010051 Ovarian Neoplasms Cisplatin 2.9319769630 15464296 6897625 17225452
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.7519003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.7516929163 19003803 15113037 16500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.5515464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.6617638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3819082440 18626508
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1915538739 16160472 18722050 18286688
MESH:D051437 Renal Insufficiency Cisplatin 4.6715464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.6714601052
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.6615464296
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms Cisplatin 2.7415958060 17522103 18396642
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7416424979 17498489 17522103 19015929 17172411 18396642 16951190 19084572 18567086 15786421
MESH:D013736 Testicular Neoplasms Cisplatin 4.8515464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7816049721
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.7815464296 12973940 17225452
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 10.3016803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 10.3016803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014625 Vaginal Neoplasms Cisplatin 4.8715577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
MESH:D014839 Vomiting Cisplatin 5.0311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
KEGG:04130 SNARE interactions in vesicular transport
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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