AutismKB 2.0

Annotation Detail for TPTE2


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Basic Information Top
Gene Symbol:TPTE2 ( MGC149231,TPIP )
Gene Full Name: transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
Band: 13q12.11
Quick LinksEntrez ID:93492; OMIM: 606791; Uniprot ID:TPTE2_HUMAN; ENSEMBL ID: ENSG00000132958; HGNC ID: 17299
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TPTE2 mRNAaffects expression 17562736
D004041 Dietary Fats Dietary Fats results in decreased expression of TPTE2 mRNAdecreases expression 18042831
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of TPTE2 mRNAaffects cotreatment|increases expression 17183730
C041786 palm oil palm oil results in decreased expression of TPTE2 mRNAdecreases expression 18042831
C410733 scriptaid scriptaid affects the expression of TPTE2 mRNAaffects expression 18813790
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of TPTE2 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618558336 19460635 18396377 17688650 18985861 17507914 15238991 17157402 20603192 18316065 19232924 18775368 18177632 18940202 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 3.2117594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.598888407
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8020734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0417522070 14725611 14986274 12958197 11739529 17906064 17562736 11461765 19420014 16781746 10663392 12540782 10774834 11287661 12153990 12705907 15968718 11529661 19164858 10915739 19085960 14550746 11743745 19739265 16485898 19416960 19370779 18071297 11834606 12594235 16109766 11421492 15619225 16393943 12392966 16227642 19923254 16081117 2444490 18713872 16177239
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.041733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.573659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.443922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.876254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D005234 Fatty Liver Dietary Fats 9.0018296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Valproic Acid 9.0019224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.5118558336 8888407
MESH:D005355 Fibrosis Dietary Fats 3.9418296743
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.0416612254
MESH:D007249 Inflammation Dietary Fats 2.5720412841
MESH:D007333 Insulin Resistance Dietary Fats 3.3018457598 11836018
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0318296743
MESH:D008107 Liver Diseases Acetaminophen 1.6919460945 12969438 19784758 11587558 19014921 16611625 12587719 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008881 Migraine Disorders Valproic Acid 3.4118803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3117596541
MESH:D009436 Neural Tube Defects Valproic Acid 3.3216359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity Dietary Fats 2.3418457598 21332399 16723640 18674790 11836018 19632207 20518802 17217161 20132043
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2920603192
MESH:D019310 Pseudolymphoma Valproic Acid 5.0612752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5319155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9417978042 14763951 11738929 1511512 15475178 11044598 16876388 3137016
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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