AutismKB 2.0

Annotation Detail for SLIT2


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Basic Information Top
Gene Symbol:SLIT2 ( FLJ14420,SLIL3,Slit-2 )
Gene Full Name: slit homolog 2 (Drosophila)
Band: 4p15.31
Quick LinksEntrez ID:9353; OMIM: 603746; Uniprot ID:SLIT2_HUMAN; ENSEMBL ID: ENSG00000145147; HGNC ID: 11086
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200021Glypican 1 network
Pathway IDPathway Name
P00008Axon guidance mediated by Slit/Robo
Pathway IDPathway Name
500092Signaling by Robo receptor
500093Regulation of Commissural axon pathfinding by Slit and Robo
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2081Pulmonary fibrosis
Desease Name
Echocardiographic traits
CARDIOVASCULAR
Desease Name
Echocardiographic traits
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of SLIT2 mRNAdecreases expression 20406850
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLIT2 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLIT2 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of SLIT2 mRNAaffects expression 17331233
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLIT2 mRNAdecreases expression 20018196
19150397
20382639
D016572 Cyclosporine Cyclosporine results in increased expression of SLIT2 mRNAincreases expression 20106945
C017180 decamethrin decamethrin results in decreased expression of SLIT2 mRNAdecreases expression 19017407
C014347 decitabine decitabine results in increased expression of SLIT2 mRNAincreases expression 19100240
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of SLIT2 mRNAdecreases expression 20713471
C006253 pirinixic acid pirinixic acid results in increased expression of SLIT2 mRNAincreases expression 17426115
D012643 Selenium Selenium results in decreased expression of SLIT2 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLIT2 mRNAdecreases expression 16443690
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0014514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000236 Adenoma Methylcholanthrene 3.566695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5111922910
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms decitabine 1.9619208741 18320071
MESH:D001943 Breast Neoplasms Methylcholanthrene 1.9617474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Methylcholanthrene 8.6310545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.6316835633
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 19100240
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0816705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.0812907637 12619106 21507988
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6219215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.676135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.6720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.6712371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 16.6716192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1412621046 16354765 15668235 15340226 8697196
MESH:D003092 Colitis Selenium 3.9217936198
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities decamethrin 2.9619861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.9610048152 15322242 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1618551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.3721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Selenium 6.3715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2919294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 7.9319224547
MESH:D005234 Fatty Liver pirinixic acid 7.9319236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.0914633661 10962813
MESH:D005355 Fibrosis Cyclosporine 8.9512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5619215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 7.1720558911
MESH:D006333 Heart Failure Selenium 7.1717162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.7316221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2218606429 8697196 15340226 16959395 16354765
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007248 Infertility, Male decitabine 3.2717581917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112200463 12878042
MESH:D007251 Influenza, Human Selenium 4.3716624496
MESH:D007299 Insect Bites and Stings decamethrin 5.9715189238
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.408314463 18776723 10903974
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.5816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5812371664
MESH:D007938 Leukemia decitabine 3.1219235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.1117236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3918704418 18460780 17679729 18206229 19387464 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6418055864
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1612878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.997678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.9918177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms pirinixic acid 10.9915890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.706135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.708603461
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 14.70598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.7012151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.1617365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5314755239
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.531399818 16271038 15390079 21163286 17909032 20512841 7750092 20970405 10545420 11893704 16337739 6695378 9230183
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5319555203 11884234
MESH:D008223 Lymphoma decitabine 3.4919470736
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8315318939
MESH:D008545 Melanoma decitabine 2.2617785578 16505122
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.4716966607 16166281 18303189
MESH:D008654 Mesothelioma Selenium 6.4715107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009101 Multiple Myeloma decitabine 3.4218172295
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4419010910 19157545 16882708 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.017678174 18551238
MESH:D009369 Neoplasms decitabine 5.1919116145 17925555 19470736
MESH:D009369 Neoplasms pirinixic acid 5.1917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5316049721
MESH:D010051 Ovarian Neoplasms decitabine 2.6819331143 19259094
MESH:D010190 Pancreatic Neoplasms decitabine 2.8019294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.0310923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11118676 11222880 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.8717616702
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0617365031 17975199 15814490 17322281
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5219155313
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6118551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms decitabine 3.4117967635
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3016049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.3019087683 17616700
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4710091137
MESH:D014604 Uveal Neoplasms decitabine 5.0917785578
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04360 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35939
    • No data
    Releated disease ID Related disease Name
    PA443635Cardiovascular Diseases
    Releated drug ID Related drug Name
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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