AutismKB 2.0

Annotation Detail for PPIG


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Basic Information Top
Gene Symbol:PPIG ( CARS-Cyp,CYP,MGC133241,SCAF10,SRCyp )
Gene Full Name: peptidylprolyl isomerase G (cyclophilin G)
Band: 2q31.1
Quick LinksEntrez ID:9360; OMIM: 606093; Uniprot ID:PPIG_HUMAN; ENSEMBL ID: ENSG00000138398; HGNC ID: 14650
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PPIG mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PPIG mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PPIG mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of PPIG mRNAincreases expression 20458559
D001194 Asbestos Asbestos affects the expression of PPIG mRNAaffects expression 17297452
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PPIG mRNAdecreases expression 20382639
C423222 cotylenin A cotylenin A results in increased expression of PPIG mRNAincreases expression 16129123
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of PPIG mRNAdecreases expression 17490981
C001478 N(6)-(delta(2)-isopentenyl)adenine N(6)-(delta(2)-isopentenyl)adenine results in increased expression of PPIG mRNAincreases expression 16129123
D012643 Selenium Selenium results in decreased expression of PPIG mRNAdecreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of PPIG mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of PPIG mRNAaffects expression 18691609
D014810 Vitamin E Vitamin E results in decreased expression of PPIG mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9614514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3011798837 19825857
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D050197 Atherosclerosis Asbestos 4.2618795166
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.2316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7020435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6516705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6514691202 15073043 16217749 15553829 11135700
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.836135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8320889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315340226 12621046 8697196 15668235 16354765
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.2518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.2518551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.1618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.1621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Selenium 9.1615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5220426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5212903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver arsenic trioxide 3.3715073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7016080930
MESH:D006333 Heart Failure Selenium 3.1217162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8817440010
MESH:D019584 Hot Flashes Vitamin E 4.1114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1818606429 15340226 16354765 8697196 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912200463 12878042
MESH:D007251 Influenza, Human Selenium 11.4116624496
MESH:D007251 Influenza, Human Vitamin E 11.4116624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Vitamin E 2.8512488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.5916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.5916705839
MESH:D007938 Leukemia arsenic trioxide 2.8715070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1517050201 16968895 16467208 19850784 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2612679006 15748426 19075265 17217047 17712046 19225113 12712474 16112521 17649720 11161223 15622746 16331271 16891316 12018890 15213294 16966277 17107899 19035177 9834237 15336539 17869043 16330433 16823087 11468182 19642359
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4516882451
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3612878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3616169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.567678174
MESH:D008113 Liver Neoplasms arsenic trioxide 7.5614682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.096135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.0920377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.0912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D008171 Lung Diseases Vitamin E 3.2316863852
MESH:D008175 Lung Neoplasms arsenic trioxide 4.9811798837 19825857
MESH:D008175 Lung Neoplasms Asbestos 4.9812111688
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9819555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 4.9811062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8115318939
MESH:D008654 Mesothelioma Asbestos 6.7618310086 16564556 18709470 16919927 16319530
MESH:D008654 Mesothelioma Selenium 6.7615107826
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1619417148 11468182 14977855 19549372 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1816882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.7418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.747678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0516624393
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1710525206
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.1416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.1416049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4319769630 16624393 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5515580305
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111222880 11118676 11896295 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2819131511
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2815084515
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0516646077
MESH:D012640 Seizures 2,4-dinitrotoluene 6.0518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.0518551238
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1519014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.4816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.4816049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.4812845720 11780464 20435036 12973940
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.3910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.3910091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00172 - L-Proline Dietary supplement;Micronutrient;Non-Essential Amino Acids
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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