AutismKB 2.0

Annotation Detail for ARHGAP18


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Basic Information Top
Gene Symbol:ARHGAP18 ( FLJ25728,MGC126757,MGC138145,MacGAP,bA307O14.2 )
Gene Full Name: Rho GTPase activating protein 18
Band: 6q22.33
Quick LinksEntrez ID:93663; OMIM: 613351; Uniprot ID:RHG18_HUMAN; ENSEMBL ID: ENSG00000146376; HGNC ID: 21035
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Signaling by Rho GTPases
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ARHGAP18 mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ARHGAP18 mRNAaffects expression 21346803
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of ARHGAP18 mRNAaffects cotreatment|increases expression 17905399
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ARHGAP18 mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of ARHGAP18 mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARHGAP18 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ARHGAP18 mRNAincreases expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ARHGAP18 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ARHGAP18 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ARHGAP18 mRNAaffects cotreatment|decreases expression 17942748
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of ARHGAP18 mRNAaffects cotreatment|increases expression 17905399
C406082 monomethylarsonous acid monomethylarsonous acid results in decreased expression of ARHGAP18 mRNAdecreases expression 20024957
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARHGAP18 mRNAaffects binding|decreases expression|increases activity 19710929
D013629 Tamoxifen Tamoxifen affects the expression of ARHGAP18 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ARHGAP18 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ARHGAP18 mRNAaffects cotreatment|decreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ARHGAP18 mRNAdecreases expression 19933214
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of ARHGAP18 mRNAaffects cotreatment|increases expression 17905399
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2420127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2414692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.706695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000741 Anemia, Aplastic Benzene 4.4311369114 17661222 14761424
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001855 Bone Marrow Diseases Benzene 5.3616183116
MESH:D001943 Breast Neoplasms Benzene 2.3811921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3817474063 20146248
MESH:D001943 Breast Neoplasms Tamoxifen 2.3819200415 16273361 19103187 20065188 20544844 18821012 15668708 17242785 19289846 19066611 19487384 20005174 21138602 16202921 19115204 19244106 17261762 16818667 17049068 18629630 19410462 18997820 19288272 18984771 17440819 19142967 18425577 19059307 16873071 19011961 20390343 19221464 15565566 18855134 20859285 19155303 21152245 18815881 17893378 20135344 18351453 19189210 19189212 11161223 19084267
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3820435547
MESH:D001943 Breast Neoplasms Trichloroethylene 2.3815986119
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8816227642 16192424 15673190 10355542 15700767 16011737 15721981 3786805 18705752 16050911 16097048 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6119066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6418788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6416924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0720419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 7.2619716837
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9417681005 16919318 11677210 16105132 17110522 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 7.9419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 15340226 12621046 15668235 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Benzene 2.7015643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7020055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1218551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4719031437
MESH:D003872 Dermatitis Benzene 4.8715902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5519279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.2215998439 16227642 3732212 17522070 6623471 4309450 11566570 10915739 7440962 9327722 7120509 7179309 19085960 6884620 3786805 10092053 19336974 21278145 16177239 2869522 15968718 15027814
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2220420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 9.227120509
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.2619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1017893378 19155303 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.4515959796 61145 16239168 16045604 17595544 12795759 12631006 19224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.4515345470
MESH:D005234 Fatty Liver pirinixic acid 19.4519236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 19.4519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 8.9518705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006402 Hematologic Diseases Benzene 4.7416183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 8.6119176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6112621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 18606429 8697196 16959395 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Benzene 5.4017940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Tamoxifen 5.0219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.6116705839
MESH:D007680 Kidney Neoplasms Tamoxifen 7.6118625569
MESH:D007938 Leukemia Benzene 3.4318335105 17119257 15935818 14694614
MESH:D007951 Leukemia, Myeloid Benzene 4.4017506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7119478238
MESH:D008064 Lipidoses Tamoxifen 3.2115342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8517334410 11408273 21278145 16943688 17157831 11903743 16221502 16239168 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.9918472332 12445418 18317297 17714472 16011737 15338365 15959796 17761835 18472094 12546737 16638106 18156304 16136751 16027843 14748882 17698563 14620537 18429990 17565644 17708605 18263696 12445421 12649538 18418968 16116963 12898905 17481882 17525996 15925388 18205269 17823541 18279442 15931870 12632514 17976157 15818738 17922224 15730626 14512876 12667390 18006644 18054572 18277467 18395914 15370692 10355542 12666154 17805973 14716496 13678700 15052691 18251166 17869086 18412020 15650968 15876570 12958196 17721639 15996030 17557913 14724832 18376398 14716833 18210741 16033810 17640975 12586293 12389079 18166357 15673190 18481824 16248980 12741479 16015684 11481614 16097048 20821823 15123356 17944888 17766677 18420326 15057751 18705752 18187930 18339082 18395095 12609069 15362042 17900296 17631135 16192424 12632512 15893842
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.9918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9912878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1016246199 17285989 15720792 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7714706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.5420195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.5419294768
MESH:D008113 Liver Neoplasms pirinixic acid 14.5415890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 14.5416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.5416984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 14.6112562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.6115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.6112151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 14.617955063
MESH:D017563 Lung Diseases, Interstitial Benzene 4.9414698565
MESH:D008175 Lung Neoplasms Benzene 4.9212562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9218816296 17053015 20135361 18520028 20064080 20464547 18569708 6695378 20869020
MESH:D008175 Lung Neoplasms Tamoxifen 4.9218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9219555203 11884234
MESH:D008223 Lymphoma Benzene 3.7917119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 10.4712562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 10.4719428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.4111921183
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.4111731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.6819453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3015990972
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D009101 Multiple Myeloma Benzene 3.7217119195
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9718551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 8.5711141357
MESH:D009369 Neoplasms pirinixic acid 8.5717405874
MESH:D009369 Neoplasms Trichloroethylene 8.5711911487
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1319189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects Benzene 3.7215643154
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4216049721 12819281
MESH:D009784 Occupational Diseases Benzene 9.4217119257 15935809 15913788 15727169 16737584 15612468 17479406 17178637 15576619
MESH:D010051 Ovarian Neoplasms Benzene 2.9912562636
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111118676 11896295 11222880 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1117292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5818551238
MESH:D012871 Skin Diseases monomethylarsonous acid 3.3917431481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5910029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.0116709447
MESH:D013088 Spermatocele Tamoxifen 12.0116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1519457130
MESH:D013274 Stomach Neoplasms Benzene 2.5912562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.592093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013953 Thymus Neoplasms Benzene 5.0710850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.2116049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.2117053015
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 12.2120375083
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.2116712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4310091137
MESH:D014594 Uterine Neoplasms Benzene 9.8912562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.8914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
REACT:11044 Signaling by Rho GTPases
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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