AutismKB 2.0

Annotation Detail for CADPS2


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Basic Information Top
Gene Symbol:CADPS2 ( FLJ40851,KIAA1591 )
Gene Full Name: Ca++-dependent secretion activator 2
Band: 7q31.32
Quick LinksEntrez ID:93664; OMIM: 609978; Uniprot ID:CAPS2_HUMAN; ENSEMBL ID: ENSG00000081803; HGNC ID: 16018
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
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Desease Name
Brain structure
NEUROLOGICAL
Desease Name
Brain structure
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CADPS2 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone affects the expression of CADPS2 mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of CADPS2 mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CADPS2 mRNAdecreases expression 20106945
D002994 Clofibrate Clofibrate affects the expression of CADPS2 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in increased expression of CADPS2 mRNAincreases expression 20106945
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CADPS2 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of CADPS2 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CADPS2 mRNAaffects cotreatment|increases expression 17942748
D005001 Ethionine Ethionine affects the expression of CADPS2 mRNAaffects expression 19483382
D005047 Etoposide CADPS2 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D016685 Mitomycin CADPS2 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D009853 Omeprazole Omeprazole affects the expression of CADPS2 mRNAaffects expression 19483382
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CADPS2 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of CADPS2 mRNAdecreases expression 19482888
C006253 pirinixic acid pirinixic acid affects the expression of CADPS2 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of CADPS2 mRNAaffects expression 19483382
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CADPS2 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CADPS2 mRNAdecreases expression 19619570
20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CADPS2 mRNAaffects cotreatment|increases expression 17942748
D013853 Thioacetamide Thioacetamide affects the expression of CADPS2 mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.276195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2715322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9720464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 6.9711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9714692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.646695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.2517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.2516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.2516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0619183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7820041841 18218290 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.8918651412 19698954
MESH:D001321 Autistic Disorder marker/mechanism 17380209
MESH:D001778 Blood Coagulation Disorders Amiodarone 58.3319483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 58.3319483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 58.3319483382
MESH:D001778 Blood Coagulation Disorders Ethionine 58.3319483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 58.3319483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 58.3319483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 58.3319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 58.3312125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 58.3319483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.1614601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9520146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 1.9517289903 16675129 12948864 17261762 19861407 18497071 14630087 17018787
MESH:D001943 Breast Neoplasms Etoposide 1.9516322251
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.8712907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 8.871701930
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.8716924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.871701930 17173139 20935162 20007298 6705139
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 8.8717997003
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0420419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8819225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0818974383
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 11.161399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.1612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.1618566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.244080065
MESH:D002637 Chest Pain Omeprazole 5.1115447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4916835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.4918291259
MESH:D002779 Cholestasis Cyclosporine 13.2519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.2511677210 16919318 15861022 16105132 17110522 17681005 17333356
MESH:D002779 Cholestasis pirinixic acid 13.2519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0916354765 12621046 8697196 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3919279558
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.2815265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2820420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 6.2812963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.3117151854 16613094 15991576 21218061
MESH:D050171 Dyslipidemias Clofibrate 4.0516707586
MESH:D004421 Dystonia Phenobarbital 3.991851702
MESH:D004487 Edema pirinixic acid 6.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9018230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1712538720
MESH:D016889 Endometrial Neoplasms Estradiol 2.9711473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0010568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.093659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.8711558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.8820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.526401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.247750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.013659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005218 Fat Necrosis Thioacetamide 5.7216456712
MESH:D005234 Fatty Liver Amiodarone 24.4814986274
MESH:D005234 Fatty Liver Clofibrate 24.4819224547
MESH:D005234 Fatty Liver Cyclosporine 24.4819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.4815345470
MESH:D005234 Fatty Liver pirinixic acid 24.4819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005355 Fibrosis Cyclosporine 8.4412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4420067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.5517276928 15929193 18665440
MESH:D006505 Hepatitis Thioacetamide 4.2016456712
MESH:D006529 Hepatomegaly Amiodarone 20.5915265979
MESH:D006529 Hepatomegaly Phenobarbital 20.5916109766
MESH:D006529 Hepatomegaly pirinixic acid 20.5919176532 18467677 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 20.5912621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.0315709030
MESH:D006561 Herpes Simplex Etoposide 4.5510809021
MESH:D006689 Hodgkin Disease Etoposide 3.8517606976 16200630 16135485 18180244 15147373
MESH:D019584 Hot Flashes Estradiol 3.7517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516959395 15340226 8697196 18606429 16354765
MESH:D006937 Hypercholesterolemia Amiodarone 3.859751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006973 Hypertension Cyclosporine 4.9210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9218850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 11.5717991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 11.578137927 18031379
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4717937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8412878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.1516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.1516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Cyclosporine 5.908314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.9015618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.2112371664
MESH:D007680 Kidney Neoplasms Estradiol 7.2115610895
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.0819248655
MESH:D008064 Lipidoses Amiodarone 3.4915342952 17567588
MESH:D008103 Liver Cirrhosis Phenobarbital 2.8821047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9312878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.9311172339 18295389 18606216 15474484 12891558 11682029 15334695 18031379 10677585 15095483 11481614 16343077 18032466 15716488 12531686 15158331 15288473 17629604 17050028 15288472 18263696 17355460 12085344 16489207 18615449 18458672 16126171 18380797 15078482 17292413 16098781 16097051 12557150 15362042 18416461 12175628 15075984 16248980 18395095 15465738 14739098 12679928 17127702 16511523 15316131
MESH:D008107 Liver Diseases Phenobarbital 4.3119363144
MESH:D008107 Liver Diseases Thioacetamide 4.3118374380 15158337 16337175
MESH:D017114 Liver Failure, Acute Thioacetamide 4.2915633222 15313186 12479984 17276928
MESH:D008113 Liver Neoplasms Aflatoxin B1 17.9018177683 2125692 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.9020195826 21137059
MESH:D008113 Liver Neoplasms Mitomycin 17.9015113037
MESH:D008113 Liver Neoplasms Phenobarbital 17.908742319 19812893 15975961 19073162 19482888 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 17.9016377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.9016984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.748603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.7418308698 6150874 17172636 2563599 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7412151625
MESH:D008133 Long QT Syndrome Amiodarone 3.5617391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 3.3612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4818516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.3514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3520064080 6695378 20869020 18520028 18816296 17053015 18569708 20135361 20464547
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3511884234 19555203
MESH:D008223 Lymphoma Etoposide 3.9112854902 12556972
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5416891317 11408345 17203775 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.4819453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009181 Mycoses Amiodarone 4.9017974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4717484760
MESH:D009369 Neoplasms Benzo(a)pyrene 4.7911141357
MESH:D009369 Neoplasms pirinixic acid 4.7917405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2718481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.4116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.4114600291
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.929802331
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D010018 Osteomalacia Phenobarbital 4.3617016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.2119401270
MESH:D010190 Pancreatic Neoplasms Etoposide 8.8119003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 8.8115113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.8116965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.9112371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.912563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1811399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6317292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.6316740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.6317172428
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.5012752131
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8411597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012512 Sarcoma, Ewing's Etoposide 4.6914601052
MESH:D012640 Seizures Phenobarbital 2.683137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.816407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0818724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.4410029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9416709447
MESH:D013272 Stomach Diseases Omeprazole 4.6018545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer Amiodarone 7.5118087811
MESH:D013276 Stomach Ulcer Omeprazole 7.5111906479 15991576 16755016 18237397 10750652 17977527
MESH:D013610 Tachycardia Amiodarone 4.2711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.1719225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Amiodarone 12.0519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.0512697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.381399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.3815710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.8519584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.6919048282
MESH:D016171 Torsades de Pointes Amiodarone 4.1817467628 11989578
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1717053015
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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