AutismKB 2.0

Annotation Detail for SLC9A3R1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC9A3R1 ( EBP50,NHERF,NHERF1,NPHLOP2 )
Gene Full Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
Band: 17q25.1
Quick LinksEntrez ID:9368; OMIM: 604990; Uniprot ID:NHRF1_HUMAN; ENSEMBL ID: ENSG00000109062; HGNC ID: 11075
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200069Thromboxane A2 receptor signaling
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1826Cystic fibrosis
1944Breast cancer
2022Liver cancer
Desease Name
HEMATOLOGICAL
fibrinogen
IMMUNE
psoriasis
No data
Desease Name
Nephrolithiasis/osteoporosis, hypophosphatemic, 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SLC9A3R1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC9A3R1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of SLC9A3R1 mRNAaffects expression 18414638
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of SLC9A3R1 mRNAaffects cotreatment|decreases expression 17905399
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC9A3R1 mRNAaffects expression 17484886
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SLC9A3R1 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC9A3R1 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SLC9A3R1 mRNAaffects cotreatment|affects expression 17602206
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of SLC9A3R1 mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in increased expression of SLC9A3R1 mRNAincreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SLC9A3R1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SLC9A3R1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SLC9A3R1 mRNAincreases expression 15834898
D005419 Flavonoids Flavonoids results in decreased expression of SLC9A3R1 mRNAdecreases expression 18035473
D019833 Genistein Genistein results in increased expression of SLC9A3R1 mRNAincreases expression 15289156
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of SLC9A3R1 mRNAaffects cotreatment|decreases expression 17905399
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of SLC9A3R1 mRNAincreases expression 17616710
D011374 Progesterone Progesterone results in decreased expression of SLC9A3R1 mRNAdecreases expression 18037150
D020849 Raloxifene Raloxifene affects the expression of SLC9A3R1 mRNAaffects expression 14699072
D012172 Retinaldehyde Retinaldehyde binds to SLC9A3R1 proteinaffects binding 16553463
C057823 salmeterol salmeterol promotes the reaction [CFTR protein binds to SLC9A3R1 protein]affects binding|increases reaction 12621035
C017947 sodium arsenite sodium arsenite results in increased expression of SLC9A3R1 mRNAincreases expression 16322246
D013629 Tamoxifen Tamoxifen affects the expression of SLC9A3R1 mRNAaffects expression 17555576
D014050 Toluene Toluene affects the expression of SLC9A3R1 mRNAaffects expression 18653662
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of SLC9A3R1 mRNAaffects cotreatment|decreases expression 17905399
D014801 Vitamin A [Vitamin A co-treated with RLBP1 protein] binds to SLC9A3R1 proteinaffects binding|affects cotreatment 16553463
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3814745880
MESH:D000015 Abnormalities, Multiple Vitamin A 4.7110992263
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D000230 Adenocarcinoma Estradiol 6.8111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.8114692618
MESH:D000230 Adenocarcinoma Genistein 6.8111473722
MESH:D000236 Adenoma Diethylnitrosamine 2.7510737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.7317620307 16434500 19061943 18056438 17162532 19052882
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5315276417
MESH:D018246 Adrenocortical Adenoma Arsenic 13.2217306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 13.2217306315 16712894
MESH:D000419 Albuminuria Raloxifene 4.4317451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5015800139
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3115469931
MESH:D000740 Anemia Vitamin A 4.3716960172
MESH:D000741 Anemia, Aplastic Benzene 4.2411369114 17661222 14761424
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.6516960172
MESH:D000799 Angioedema Acetaminophen 11.6810982225
MESH:D000799 Angioedema salmeterol 11.6810982225
MESH:D020261 Arsenic Poisoning Arsenic 2.8218414634 12569548 16251483 16835338
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5615885639
MESH:D001249 Asthma salmeterol 5.7511694805 10359889
MESH:D001249 Asthma Vitamin A 5.7516732791
MESH:D001250 Asthma, Exercise-Induced salmeterol 5.9510984370
MESH:D050197 Atherosclerosis Arsenic 3.1512928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001855 Bone Marrow Diseases Benzene 5.0616183116
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1717868700
MESH:D001930 Brain Injuries Progesterone 10.4015380490 15845082 15665606
MESH:D001930 Brain Injuries Raloxifene 10.4016580743
MESH:D001943 Breast Neoplasms Benzene 5.6717162533 11921183
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.6717474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 5.6717129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 5.6717261762 12948864 18497071 16675129 17289903 17018787 14630087 19861407
MESH:D001943 Breast Neoplasms Genistein 5.6716873071 16541309 17200150
MESH:D001943 Breast Neoplasms Progesterone 5.6715562024 16175315 17614352
MESH:D001943 Breast Neoplasms Raloxifene 5.6716837676 15758505 15572757 16912660 17440819 17893378 17261762 17242785 17595753 17049068 17952589 15775269
MESH:D001943 Breast Neoplasms Tamoxifen 5.6718984771 17893378 20859285 16202921 18425577 19142967 19288272 20390343 20135344 20544844 19155303 17261762 17440819 19084267 18821012 21138602 16873071 19189212 18351453 19487384 18855134 19221464 16818667 19011961 16273361 19115204 19200415 19410462 19066611 15668708 21152245 18815881 19059307 19189210 11161223 17049068 19103187 15565566 20065188 18629630 17242785 19289846 18997820 19244106 20005174
MESH:D001943 Breast Neoplasms Trichloroethylene 5.6715986119
MESH:D029481 Bronchitis, Chronic salmeterol 6.3817687719
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 5.4317377406 17426644
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2916111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6115673190 16124888 15700767 16050911 16227642 16011737 10355542 16192424 15721981 3786805 18705752 16097048
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5015504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3419066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.373084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 19.3716507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.3718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 19.3718665156 20935162 20432363 17978847 19394651 20007298 19335982 21159647 3581430 16935385 19418558 17173139 16830150 19919837 20512989 16288022 20514400 3084413 16698587 20214788 16502159 19701751 16540662 18210153 19519916 18506893 10737359 19822196 16878318 11831363 18971187 20524982 20084675 20727157 16328049 16779866 18788625 19208518 18494052 18393292 18691550 19052882 16807293 16569478 18056438 19539802 16681979 17138121 17162532 17428255 19107877 19171122 20101231 17055752 19383236 10672840 18785209 17761372 18978308
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 19.3715948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.3716924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 19.3716924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 19.3716507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 19.3716924424
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.6718922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.6718572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 15.0518640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 15.0517572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 15.0517572228
MESH:D002318 Cardiovascular Diseases Arsenic 11.5719152805 15738583 17938729
MESH:D002318 Cardiovascular Diseases Genistein 11.5716332659
MESH:D002318 Cardiovascular Diseases Raloxifene 11.5715775269
MESH:D002340 Carotid Artery Diseases Arsenic 4.1616973168 18022660
MESH:D002386 Cataract Acetaminophen 2.4810977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.0512371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.052727394 17174075 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.0518566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.0519524636 20056578
MESH:D002547 Cerebral Palsy Toluene 5.689294310
MESH:D015362 Child Nutrition Disorders Vitamin A 5.3016153327
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5419052882
MESH:D002779 Cholestasis Cyclosporine 12.8119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.8111677210 17110522 16105132 17333356 17681005 15861022 16919318
MESH:D002779 Cholestasis Vitamin A 12.8116175620
MESH:D002972 Cleft Palate Vitamin A 3.6116054864
MESH:D003072 Cognition Disorders Raloxifene 4.4515800139
MESH:D003110 Colonic Neoplasms Genistein 4.0417182828
MESH:D003110 Colonic Neoplasms Vitamin A 4.0417219422 16267017
MESH:D019465 Craniofacial Abnormalities Benzene 4.0815643154
MESH:D019465 Craniofacial Abnormalities Toluene 4.089294310
MESH:D019465 Craniofacial Abnormalities Vitamin A 4.0810992263
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3916002989 12952375
MESH:D003643 Death Toluene 5.496431079
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1919031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0217474826
MESH:D003872 Dermatitis Benzene 4.6015902427
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4616506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3820387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3816647724
MESH:D003928 Diabetic Nephropathies Estradiol 14.1819279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.1817308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.1819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3217187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.6011743745 18713872 19416960 16227642 11287661 2444490 17906064 12153990 10915739 15968718 16109766 14986274 11739529 10774834 14725611 19923254 11461765 19085960 18071297 17522070 11529661 15619225 12705907 11421492 16781746 10663392 19739265 14550746 16081117 16485898 16177239 17562736 12958197 19164858 19370779 19420014 12594235 11834606 16393943 12540782 12392966
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.6016227642 21278145 16177239 11566570 19336974 15998439 2869522 6884620 3732212 3786805 9327722 7179309 17522070 7120509 7440962 10092053 19085960 15027814 15968718 10915739 4309450 6623471
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.6019107877
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 8.607120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D015352 Dry Eye Syndromes Vitamin A 5.6316146918
MESH:C538011 Eales disease Vitamin A 5.459068938
MESH:D004480 Ectromelia Vitamin A 5.6516054864
MESH:D004487 Edema Raloxifene 3.1915860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 20.5612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 20.5617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 20.5615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 20.5619031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.3216402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.3216402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.8815700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 16.8818566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 16.8811473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.8819155303 16202921 20544844 17893378
MESH:D004715 Endometriosis Progesterone 3.6116134523
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9416302075
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7315547733 15150132 16805852 15623463 15264214 16704527 15878914 16510608 15547721
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.6919224547 16239168 12631006 15959796 17595544 61145 12795759 16045604
MESH:D005234 Fatty Liver Cyclosporine 28.6919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 28.6921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.6915345470
MESH:D005234 Fatty Liver Raloxifene 28.6917473493
MESH:D005234 Fatty Liver Tamoxifen 28.6919224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.8716002989 16611131 16534752 15751030 16513791
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.8716709447
MESH:D005327 Fetal Resorption Vitamin A 5.1916054864
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0119069698
MESH:D005355 Fibrosis Carbon Tetrachloride 8.1018705752
MESH:D005355 Fibrosis Cyclosporine 8.1012168785 12639820
MESH:D005534 Foot Diseases Arsenic 5.396392382
MESH:D005756 Gastritis Acetaminophen 3.5016983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 12.2416452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 12.2416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.058708960
MESH:D005909 Glioblastoma Genistein 3.1516598420
MESH:D006330 Heart Defects, Congenital Vitamin A 3.8210992263 16080930
MESH:D006331 Heart Diseases Raloxifene 3.4211110106
MESH:D006402 Hematologic Diseases Benzene 4.4916183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2515720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4319900420 19110552
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.5616863852 15707848 16490937 17436238 16292552 16877224
MESH:D006558 Herpes Genitalis Estradiol 4.8615709030
MESH:D015658 HIV Infections Vitamin A 3.7316960176
MESH:D006679 HIV Seropositivity Vitamin A 5.4317209195
MESH:D006689 Hodgkin Disease sodium arsenite 3.0112676792
MESH:D019584 Hot Flashes Estradiol 3.5817088409
MESH:D006930 Hyperalgesia Acetaminophen 2.5716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3017050553
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2712960047 14722030
MESH:D006973 Hypertension Arsenic 11.9016076760 9931084 11953799
MESH:D006973 Hypertension Benzene 11.9017940673
MESH:D006973 Hypertension Cyclosporine 11.9010903974
MESH:D006973 Hypertension Raloxifene 11.9015787275 17577099
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D006986 Hypervitaminosis A Vitamin A 6.0016054864
MESH:D006987 Hypesthesia Arsenic 5.3916093927
MESH:D007021 Hypospadias Diethylstilbestrol 10.6716002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.6716569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2315869954
MESH:D007246 Infertility Diethylstilbestrol 4.1915036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2617937319
MESH:D007248 Infertility, Male sodium arsenite 6.2615346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 11.2618785209
MESH:D007249 Inflammation Flavonoids 11.2617296493
MESH:D007249 Inflammation Progesterone 11.2615869954
MESH:D007249 Inflammation Tamoxifen 11.2619457130
MESH:D007333 Insulin Resistance Estradiol 2.8616393666 16627594
MESH:D019586 Intracranial Hypertension Vitamin A 5.6515955940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2715604871
MESH:D007642 Keratosis Arsenic 4.8212749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 13.6115629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 13.6118776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 13.6115618244
MESH:D007674 Kidney Diseases sodium arsenite 13.6120008137
MESH:D007680 Kidney Neoplasms Cyclosporine 16.6112371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 16.6116762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 16.6115610895
MESH:D007680 Kidney Neoplasms Tamoxifen 16.6118625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8917184923
MESH:D007889 Leiomyoma Raloxifene 4.3316973256
MESH:D007938 Leukemia Benzene 6.3617119257 18335105 15935818 14694614
MESH:D007938 Leukemia Genistein 6.3618980019 17468513
MESH:D007951 Leukemia, Myeloid Benzene 4.1617506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6719478238
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.4417339181
MESH:D017880 Limb Deformities, Congenital Vitamin A 4.1916054864
MESH:D008064 Lipidoses Tamoxifen 3.0317567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.6111408273 17157831 17174718 11903743 17334410 16943688 21278145 16239168 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.6120032147 19638242 18665156 18522880 18407596
MESH:D008103 Liver Cirrhosis Vitamin A 10.6116256175
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.4812741479 16033810 18166357 12445418 12632512 16015684 12958196 17761835 12586293 15673190 15123356 12649538 18205269 18277467 18418968 12609069 16116963 17900296 17565644 18263696 15996030 17714472 12898905 15959796 18339082 14724832 18395914 16638106 16027843 14716833 18705752 18420326 15362042 18054572 17766677 17976157 17721639 17805973 18412020 18210741 12667390 18472332 18481824 15931870 18187930 17869086 18429990 17698563 10355542 16136751 15876570 12389079 15057751 14620537 17557913 17708605 18251166 15893842 16192424 18006644 12445421 16248980 18317297 12632514 15818738 15925388 17631135 15052691 13678700 11481614 12546737 17481882 17525996 18395095 17640975 16097048 18156304 14748882 17944888 18376398 18279442 14716496 15730626 15650968 17922224 18472094 12666154 16011737 20821823 17823541 15338365 14512876 15370692
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.4814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.4817823541
MESH:D008106 Liver Cirrhosis, Experimental Retinaldehyde 8.4816248980
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.4818564211
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 8.4816248980
MESH:D008107 Liver Diseases Acetaminophen 12.0619014921 16610002 19784758 12587719 19460945 16611625 12969438 11587558
MESH:D008107 Liver Diseases Arsenic 12.0611134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 12.0616246199 16964402 15720792 15830285 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 12.0617034775
MESH:D008107 Liver Diseases Vitamin A 12.0616175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.9816762690
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9117185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9114706259 16899240
MESH:D008113 Liver Neoplasms Arsenic 20.9116368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.9119294768
MESH:D008113 Liver Neoplasms Clofibric Acid 20.9117602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.9121047994 18754104 18978307 19427195 19551842 19426721 20583210 19812893 19255062 19294768 20405173 9163691 15885732 18644402 19850985 19073162 21167192 12112319 19642983 18977376 2862719 19638242 10737359 20137499 20118626 18648771 20501860 20101389 2422723 20452335 20434301 19254457 19090486 19690152 20492335 19499222 21071580 19833225 19996281 15175105 21278145 12771043 16942905 19256749
MESH:D008113 Liver Neoplasms Diethylstilbestrol 20.9115890375 16712894
MESH:D008113 Liver Neoplasms sodium arsenite 20.9116712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 20.9116684651
MESH:D008114 Liver Neoplasms, Experimental Benzene 17.5712562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.5715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.5717174075 18544905 2563599 18164116 17942915 18775883 18282651 18093689 19539802 18253720 19519916 18079962 3124819 19126423 9362446 18308698 19009564 17854601 16842330 19004024 21159647 16267830
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 17.577955063
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 17.5717113696
MESH:D008171 Lung Diseases sodium arsenite 7.4019095001
MESH:D008171 Lung Diseases Vitamin A 7.4016863852
MESH:D017563 Lung Diseases, Interstitial Benzene 4.6414698565
MESH:D008175 Lung Neoplasms Arsenic 6.3817306315 17976673 19168569
MESH:D008175 Lung Neoplasms Benzene 6.3812562636
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.386695378 21163286 20970405 20512841
MESH:D008175 Lung Neoplasms sodium arsenite 6.3817306315 16712894 17077188 19931552 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 6.3818625569
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9815166399
MESH:D008223 Lymphoma Benzene 7.4417584886 17119257
MESH:D008223 Lymphoma Diethylstilbestrol 7.4415700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3416002989
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.5012562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.5019428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 17.6711921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 17.6717203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 17.6712929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 17.6717203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 17.6719196723 11731420 19196722 14580682 16827153
MESH:D020149 Manganese Poisoning Estradiol 12.0719453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.0719453300
MESH:D008545 Melanoma sodium arsenite 3.2216487513 19082730
MESH:D008545 Melanoma Tamoxifen 3.2219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4019513568
MESH:D008607 Mental Retardation Toluene 3.599294310
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6216801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3815863610
MESH:D019957 Motor Skills Disorders Toluene 5.079294310
MESH:D009101 Multiple Myeloma Benzene 11.6417119195
MESH:D009101 Multiple Myeloma Raloxifene 11.6416497877
MESH:D009101 Multiple Myeloma Vitamin A 11.6416374440
MESH:D009203 Myocardial Infarction Genistein 2.7917141266
MESH:D017202 Myocardial Ischemia Arsenic 3.8515371236
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.0817141266
MESH:D009232 Myxoma Raloxifene 5.3816343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.503581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.5019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4619410462
MESH:D009369 Neoplasms Diethylstilbestrol 8.0115313581
MESH:D009369 Neoplasms sodium arsenite 8.0111559025
MESH:D009369 Neoplasms Trichloroethylene 8.0111911487
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5020056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8319189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5617289903
OMIM:612287 NEPHROLITHIASIS/OSTEOPOROSIS, HYPOPHOSPHATEMIC, 2 marker/mechanism
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1419348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.5311399458
MESH:D009421 Nervous System Malformations Estradiol 15.5311399458 16427766
MESH:D009421 Nervous System Malformations Genistein 15.5316427766
MESH:D009436 Neural Tube Defects Arsenic 16.5216620997
MESH:D009436 Neural Tube Defects Benzene 16.5215643154
MESH:D009436 Neural Tube Defects sodium arsenite 16.5212854658
MESH:D009436 Neural Tube Defects Vitamin A 16.5217400914
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.7118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.7120387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.2117056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9420387270
MESH:D009784 Occupational Diseases Benzene 4.0315576619 17479406 17119257 17178637 15612468 15727169 15913788 15935809 16737584
MESH:D010024 Osteoporosis Genistein 6.9819401787
MESH:D010024 Osteoporosis Raloxifene 6.9817882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.6116169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.6115579764 17893378 17823083 15758505
MESH:D010051 Ovarian Neoplasms Arsenic 18.1717306315
MESH:D010051 Ovarian Neoplasms Benzene 18.1712562636
MESH:D010051 Ovarian Neoplasms Estradiol 18.1719401270
MESH:D010051 Ovarian Neoplasms Genistein 18.1719005980
MESH:D010051 Ovarian Neoplasms Progesterone 18.1717393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 18.1715276417 17306315
MESH:D010146 Pain Acetaminophen 2.2516870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3616540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.8215371236 6392382 16905509
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5016977796 15687265
MESH:D011230 Precancerous Conditions Cyclosporine 8.4612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.462563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 3.9417184923
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7320887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.0816140617
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0817136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.0816740699
MESH:D011471 Prostatic Neoplasms Genistein 2.0815256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0816220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0815067354
MESH:D011507 Proteinuria Arsenic 3.8421343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.1415861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1716882103
MESH:D011693 Purpura Raloxifene 5.3815770314
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.6316877224
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8018045962
MESH:D012640 Seizures Toluene 3.619294310 6431079
MESH:D012871 Skin Diseases Arsenic 5.2317453740 6392382 15952646 17938729 17050553 16759981 19834688 16353154 17548696 16702368 18709164
MESH:D012871 Skin Diseases Vitamin A 5.2318709164
MESH:D012878 Skin Neoplasms Arsenic 5.6817050553 19538983 16251483 15504454 17029826 17976673
MESH:D012878 Skin Neoplasms sodium arsenite 5.6819524636 18572023
MESH:D013088 Spermatocele Diethylstilbestrol 19.1316709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 19.1316709447
MESH:D013088 Spermatocele Tamoxifen 19.1316709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.3015862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.3019457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6612854658
MESH:D013274 Stomach Neoplasms Benzene 3.4212562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4218456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.4212958204 17575124
MESH:D020521 Stroke Raloxifene 3.6916837676
MESH:D013733 Testicular Diseases Toluene 4.7810514026 10048760
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013953 Thymus Neoplasms Benzene 4.7810850423
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.867505956
MESH:D013978 Tibial Fractures Estradiol 13.1419048282
MESH:D013978 Tibial Fractures Raloxifene 13.1419048282
MESH:D001749 Urinary Bladder Neoplasms Arsenic 15.1111144890 18640142 17976673 17306315 15987713 19429237 19322015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 15.1116712894 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 15.1117572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 15.1116712894 11723127 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.118653321 17572228 16712894
MESH:D014581 Urticaria Acetaminophen 8.7310982225
MESH:D014581 Urticaria salmeterol 8.7310982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.0416175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.0411813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0014652134
MESH:D014594 Uterine Neoplasms Benzene 15.1412562636
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 15.1416690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 15.1414692618
MESH:D014605 Uveitis Cyclosporine 3.811336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2716002989 16513791
MESH:D014652 Vascular Diseases Arsenic 11.2717056641
MESH:D014652 Vascular Diseases sodium arsenite 11.2717056641
MESH:D054556 Venous Thromboembolism Raloxifene 5.0416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3814671159 15869587
MESH:D014802 Vitamin A Deficiency Vitamin A 5.1216175781 16960172 16146918
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3816343187
MESH:D014985 Xerophthalmia Cyclosporine 4.2717120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35931
    • No data
    Releated disease ID Related disease Name
    PA446738Bone Demineralization, Pathologic
    PA162355520nephrolithiasis
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    PA164743471adenosine triphosphate
    PA164712535Beta Blocking Agents
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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