AutismKB 2.0

Annotation Detail for NRXN3


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Basic Information Top
Gene Symbol:NRXN3 ( C14orf60,KIAA0743,MGC176711 )
Gene Full Name: neurexin 3
Band: 14q24.3-q31.1
Quick LinksEntrez ID:9369; OMIM: 600567; Uniprot ID:NRX3A_HUMAN; ENSEMBL ID: ENSG00000021645; HGNC ID: 8010
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04514Cell adhesion molecules (CAMs)
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1870Drug abuse
Desease Name
Cleft Palate
Tooth Abnormalities
METABOLIC
waist circumference
DEVELOPMENTAL
Cleft Lip
Desease Name
Waist circumference
Body mass index
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D008770 Methylnitrosourea Methylnitrosourea results in decreased expression of NRXN3 mRNAdecreases expression 17412507
C025299 polyphenols polyphenols results in decreased expression of NRXN3 mRNAdecreases expression 16293270
D011189 Potassium Chloride Potassium Chloride results in increased expression of NRXN3 mRNAincreases expression 16412482
C025643 vinclozolin vinclozolin affects the expression of NRXN3 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Methylnitrosourea 3.1915688392 15113128
MESH:D001008 Anxiety Disorders vinclozolin 3.9719015723
MESH:D001943 Breast Neoplasms Methylnitrosourea 3.1311306469 14633655 16253758
MESH:D002386 Cataract Methylnitrosourea 4.2012484553
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 4.057505956 2727394
MESH:D003110 Colonic Neoplasms polyphenols 2.7216293270
MESH:D003456 Cryptorchidism vinclozolin 4.8514966744
MESH:D056486 Drug-Induced Liver Injury polyphenols 2.8219370779
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.8611555667
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.5716973722
MESH:D005832 Genital Diseases, Male vinclozolin 6.0216417039
MESH:D005910 Glioma Methylnitrosourea 3.699825942
MESH:D007248 Infertility, Male Methylnitrosourea 7.997193160
MESH:D007248 Infertility, Male vinclozolin 7.9916467254
MESH:D007249 Inflammation polyphenols 3.2316366677
MESH:D007984 Leydig Cell Tumor vinclozolin 5.3616417039
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.4815526292
MESH:D008107 Liver Diseases polyphenols 2.8516698588
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 6.0316080182
MESH:D008175 Lung Neoplasms Methylnitrosourea 2.7018062963
MESH:D008223 Lymphoma Methylnitrosourea 4.2916257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 5.2314633661
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 3.8116827153 15313902 16944150 11807958 14999141 10767621 17131329 15113128 19196723 11751437 12931682 16619500 16051031 10838139 17020996 15688392 14633655
MESH:D009369 Neoplasms Methylnitrosourea 3.4615533788
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 5.0312696579
MESH:D009442 Neurilemmoma Methylnitrosourea 6.1211555667
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 3.4716965848
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.5318220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.5718220299
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 4.0412376480 15682402
MESH:D011472 Prostatitis vinclozolin 5.5718629315
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.7018155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 6.1211555667
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.7018593901 15930296 16257854
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.9717997062
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.8611418001
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 4.227505956 3078959
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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