AutismKB 2.0

Annotation Detail for NRXN2


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Basic Information Top
Gene Symbol:NRXN2 ( FLJ40892,KIAA0921 )
Gene Full Name: neurexin 2
Band: 11q13.1
Quick LinksEntrez ID:9379; OMIM: 600566; Uniprot ID:NRX2A_HUMAN; ENSEMBL ID: ENSG00000110076; HGNC ID: 8009
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04514Cell adhesion molecules (CAMs)
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NRXN2 mRNAaffects expression 21346803
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NRXN2 mRNAaffects expression 17484886
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of NRXN2 mRNAaffects cotreatment|affects expression 18636392
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of NRXN2 mRNAaffects cotreatment|increases expression 17183730
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of NRXN2 mRNAaffects cotreatment|affects expression 18636392
D010269 Paraquat Paraquat results in increased expression of NRXN2 mRNAincreases expression 17077588
D011189 Potassium Chloride Potassium Chloride results in decreased expression of NRXN2 mRNAdecreases expression 16412482
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of NRXN2 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.828875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D055371 Acute Lung Injury Chlorine 4.5820601635
MESH:D000382 Agricultural Workers' Diseases Paraquat 4.1011874814
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6015570426
MESH:D001249 Asthma Ozone 2.7017854713 16373670
MESH:D001321 Autistic Disorder Valproic Acid 1.9919232924 17688650 18558336 18396377 18985861 17157402 15238991 18177632 18940202 18775368 20603192 16609825 19460635 18316065 17507914
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8715516495 17626835 18315731 14754758 18417511 16777450 19059883
MESH:D002100 Cachexia Ozone 5.0816183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0816192424 3786805 16227642 18705752 15673190 16097048 15721981 16050911 15700767 16011737 16124888 10355542
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0816705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0818788625
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.936135515
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 21424692
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 16575769 17688650
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.6215998439 9327722 6884620 15968718 7179309 17522070 3786805 7440962 15027814 4309450 3732212 19085960 10915739 21278145 10092053 2869522 7120509 16227642 6623471 16177239 11566570 19336974
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.6219641884 1733752
MESH:D004417 Dyspnea Chlorine 5.0020016425
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.293922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.806426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.6912631006 19224547 15959796 16239168 12795759 61145 16045604 17595544
MESH:D005234 Fatty Liver Valproic Acid 8.6919224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.418888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 3.7618705752
MESH:D005739 Gas Poisoning Chlorine 5.3920016425
MESH:D005911 Gliosis Paraquat 5.5411124998
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819900420 19110552
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9316612254
MESH:D007248 Infertility, Male Paraquat 3.404850670
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1816705839
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9211408273 11903743 21278145 17157831 17174718 16239168 17334410 16221502 16943688
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7517976157 15370692 12445421 12609069 18205269 16015684 20821823 14748882 12586293 18376398 12741479 16033810 12632514 15338365 15730626 12445418 11481614 12649538 17640975 18472332 17721639 15925388 15650968 17900296 12958196 17823541 16116963 18210741 15996030 18251166 18317297 18166357 13678700 15057751 17805973 18472094 17565644 18395914 10355542 18481824 14724832 14716496 18279442 14620537 12546737 12666154 16192424 17481882 12632512 12389079 15876570 18412020 17631135 18705752 12667390 15818738 15673190 16248980 15959796 18420326 16027843 15931870 17557913 17922224 15893842 18277467 17525996 18395095 18156304 18006644 18429990 14512876 17766677 17869086 18263696 16136751 15052691 17761835 16011737 17714472 15123356 16638106 18418968 18054572 12898905 17708605 15362042 17698563 18339082 16097048 18187930 17944888 14716833
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1316246199 16964402 15720792 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9214706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.817678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8119294768
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.392876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3915583823 12014681
MESH:D008171 Lung Diseases Ozone 3.538266340 19066396
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D055370 Lung Injury Ozone 4.1520417186
MESH:D008175 Lung Neoplasms Ozone 2.108597069 7614698
MESH:D008679 Metaplasia Ozone 5.4810496685
MESH:D008881 Migraine Disorders Valproic Acid 3.3618765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2018551238 7678174
MESH:D009410 Nerve Degeneration Paraquat 3.9016893418
MESH:D009436 Neural Tube Defects Valproic Acid 3.2716359493 8888407
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D010300 Parkinson Disease Paraquat 2.8911181820 11124998 16510128 12911755 15824117 15451049 16140633 11445065
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.7416190885
MESH:D010538 Peritonitis Ozone 4.4416369182
MESH:D011014 Pneumonia Ozone 12.2218929643 18007984 18381685
MESH:D011014 Pneumonia Paraquat 12.2212504350
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1720603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.9212752131 11422049
MESH:D011658 Pulmonary Fibrosis Paraquat 2.9916324872 17997886
MESH:D012120 Respiration Disorders Chlorine 5.5918579056
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 4.1711700416
MESH:D012135 Respiratory Sounds Paraquat 4.3611874814
MESH:D012162 Retinal Degeneration Paraquat 4.0416458197
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D012640 Seizures Valproic Acid 6.473137016 15475178 14763951 16876388 1511512 17978042 11044598 11738929
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3716049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31787
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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