Gene Symbol:	COG1 ( CDG2G,DKFZp762L1710,KIAA1381,LDLB )
Gene Full Name:	component of oligomeric golgi complex 1
Band:	17q25.1
Quick Links	Entrez ID:9382; OMIM: 606973; Uniprot ID:COG1_HUMAN; ENSEMBL ID: ENSG00000166685; HGNC ID: 6545
Relate to Another Database:	SFARIGene; denovo-db

Desease ID	Desease Name
	Inherited disorders of glycan/glycoprotein metabolism
H00119	Congenital disorders of glycosylation (CDG) type II
	Genetic disorders

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene affects the expression of COG1 mRNA	affects expression	21346803
D016572	Cyclosporine	Cyclosporine results in increased expression of COG1 mRNA	increases expression	20106945
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of COG1 mRNA	decreases expression	18087596

Disease ID	Disease Name	Direct Evidence	Inference Chemical Name	Inference Score	Publication
MESH:D002282	Adenocarcinoma, Bronchiolo-Alveolar		Tobacco Smoke Pollution	6.40	15814487
MESH:D001172	Arthritis, Rheumatoid		Tobacco Smoke Pollution	3.26	19898480
MESH:D006528	Carcinoma, Hepatocellular		2,6-dinitrotoluene	1.79	16705839
MESH:D002289	Carcinoma, Non-Small-Cell Lung		Tobacco Smoke Pollution	3.54	11212258
MESH:D002294	Carcinoma, Squamous Cell		Tobacco Smoke Pollution	3.30	11212258
MESH:D002471	Cell Transformation, Neoplastic		2,6-dinitrotoluene	7.56	6135515
MESH:D002471	Cell Transformation, Neoplastic		Cyclosporine	7.56	12371664
MESH:D002779	Cholestasis		Cyclosporine	3.24	19486331
MESH:C535756	Congenital disorder of glycosylation, type 2G	marker/mechanism
MESH:D003490	Cyanosis		2,6-dinitrotoluene	4.67	18551238
MESH:D056486	Drug-Induced Liver Injury		2,6-dinitrotoluene	2.06	18551238 21346803
MESH:D005234	Fatty Liver		Cyclosporine	3.34	19224547
MESH:D005355	Fibrosis		Cyclosporine	3.79	12639820 12168785
MESH:D005885	Gingival Hyperplasia		Cyclosporine	4.96	8708960
MESH:D006457	Hemoglobinuria, Paroxysmal		Cyclosporine	5.16	15720958
MESH:D006973	Hypertension		Cyclosporine	2.23	10903974
MESH:D007249	Inflammation		Tobacco Smoke Pollution	3.53	18590791
MESH:D007638	Keratoconjunctivitis Sicca		Cyclosporine	5.31	15604871
MESH:D007674	Kidney Diseases		Cyclosporine	2.56	8314463 18776723 10903974
MESH:D007680	Kidney Neoplasms		2,6-dinitrotoluene	8.59	16705839
MESH:D007680	Kidney Neoplasms		Cyclosporine	8.59	12371664
MESH:D008113	Liver Neoplasms		2,6-dinitrotoluene	2.28	7678174
MESH:D008114	Liver Neoplasms, Experimental		2,6-dinitrotoluene	2.79	2876786 6135515 2876784
MESH:D008175	Lung Neoplasms		Tobacco Smoke Pollution	2.73	11091918 12111688 3440675 16288123
MESH:D008664	Metal Metabolism, Inborn Errors		Cyclosporine	5.65	16801185
MESH:D009062	Mouth Neoplasms		Tobacco Smoke Pollution	4.69	15006635
MESH:D009336	Necrosis		2,6-dinitrotoluene	4.60	7678174 18551238
MESH:D009402	Nephrosis, Lipoid		Cyclosporine	5.31	17954296
MESH:D009404	Nephrotic Syndrome		Cyclosporine	3.70	19348381 18481113
MESH:D009784	Occupational Diseases		2,6-dinitrotoluene	3.88	16049721
MESH:D011230	Precancerous Conditions		Cyclosporine	3.64	12371664
MESH:D011565	Psoriasis		Cyclosporine	2.34	16882103
MESH:D012135	Respiratory Sounds		Tobacco Smoke Pollution	5.27	18410779
MESH:D012640	Seizures		2,6-dinitrotoluene	2.82	18551238
MESH:D012878	Skin Neoplasms		Tobacco Smoke Pollution	3.70	18590791
MESH:D001749	Urinary Bladder Neoplasms		2,6-dinitrotoluene	5.86	16049721
MESH:D001749	Urinary Bladder Neoplasms		Tobacco Smoke Pollution	5.86	12846360
MESH:D014571	Urologic Neoplasms		2,6-dinitrotoluene	5.06	10091137
MESH:D014605	Uveitis		Cyclosporine	4.85	1336536
MESH:D014985	Xerophthalmia		Cyclosporine	5.31	17120751

AutismKB 2.0

Annotation Detail for COG1

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics