AutismKB 2.0

Annotation Detail for LIPG


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Basic Information Top
Gene Symbol:LIPG ( EDL,EL,PRO719 )
Gene Full Name: lipase, endothelial
Band: 18q21.1
Quick LinksEntrez ID:9388; OMIM: 603684; Uniprot ID:LIPE_HUMAN; ENSEMBL ID: ENSG00000101670; HGNC ID: 6623
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
LIPAS-PWYtriacylglycerol degradation
Pathway IDPathway Name
hsa00561Glycerolipid metabolism
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1895Gestational diabetes
1918Atherosclerosis
Desease Name
HDL cholesterol
CARDIOVASCULAR
myocardial infarct
METABOLIC
HDL-cholesterol
cholesterol, total
Desease Name
HDL cholesterol
Cholesterol, total
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LIPG mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of LIPG proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LIPG mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of LIPG mRNAdecreases expression 19654921
D016572 Cyclosporine Cyclosporine results in decreased expression of LIPG mRNAdecreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of LIPG mRNAincreases expression 16002434
D004958 Estradiol Estradiol results in decreased expression of LIPG mRNAdecreases expression 20106945
C002950 methylformamide methylformamide analog results in decreased expression of LIPG mRNAdecreases expression 17040096
C002950 methylformamide methylformamide results in decreased expression of LIPG mRNAdecreases expression 17040096
D008942 Mitoxantrone LIPG protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of LIPG mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of LIPG mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of LIPG mRNAincreases expression 18301758
18445702
D011374 Progesterone Progesterone results in increased expression of LIPG mRNAincreases expression 18070364
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LIPG mRNAincreases expression 20067830
C423915 TO-901317 TO-901317 results in increased expression of LIPG mRNAincreases expression 16142410
C047426 venlafaxine venlafaxine results in increased expression of LIPG mRNAincreases expression 16341940
C540004 WAY-362450 WAY-362450 results in increased expression of LIPG mRNAincreases expression 19136377
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.366195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.3615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Estradiol 2.1011473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.4217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.4216835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.2417306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D020261 Arsenic Poisoning Arsenic 2.8712569548 18414634 16251483 16835338
MESH:D050197 Atherosclerosis Arsenic 3.2512928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3717868700
MESH:D001930 Brain Injuries Progesterone 4.2715665606 15845082 15380490
MESH:D001943 Breast Neoplasms Calcitriol 1.9511237771
MESH:D001943 Breast Neoplasms Estradiol 1.9512948864 17018787 17289903 17261762 16675129 18497071 19861407 14630087
MESH:D001943 Breast Neoplasms Progesterone 1.9516175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5915504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.883084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.8821507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Arsenic 8.8817306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.8816924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.8817173139 20007298 1701930 20935162 6705139
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.9315504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.9311237771
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.0818640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.4515738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.3116973168 18022660
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.5812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.5818566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.264080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Cyclosporine 7.7619486331
MESH:D002779 Cholestasis pirinixic acid 7.7619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1012621046 15340226 16354765 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003866 Depressive Disorder venlafaxine 4.8320305041
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5117187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.5614725611 2444490 15968718 19164858 15619225 14550746 19085960 19923254 16177239 10774834 11421492 12594235 11461765 12153990 16081117 11743745 19739265 12540782 16781746 16393943 11287661 18713872 19416960 11739529 10915739 19370779 12705907 11529661 16227642 17562736 17522070 16485898 16109766 10663392 14986274 12392966 18071297 19420014 11834606 17906064 12958197
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D050171 Dyslipidemias WAY-362450 6.2019136377
MESH:D004421 Dystonia Phenobarbital 4.011851702
MESH:D004487 Edema pirinixic acid 6.5512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9318230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.3415138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.3417692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.9811473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 8.9416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.949294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.123659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.903922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.546401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.267750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.043659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Cyclosporine 7.5819224547
MESH:D005234 Fatty Liver pirinixic acid 7.5819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Cyclosporine 8.5312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.5320067830
MESH:D005534 Foot Diseases Arsenic 5.596392382
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3311294989 10048152
MESH:D006331 Heart Diseases Mitoxantrone 4.1516019553
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006529 Hepatomegaly Phenobarbital 14.4716109766
MESH:D006529 Hepatomegaly pirinixic acid 14.4718467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.4715340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D019584 Hot Flashes Estradiol 10.7317088409
MESH:D019584 Hot Flashes venlafaxine 10.7314716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0816959395 15340226 16354765 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.4617050553
MESH:D006973 Hypertension Arsenic 8.5916076760 9931084 11953799
MESH:D006973 Hypertension Cyclosporine 8.5910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5918670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.5916093927
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4115869954
MESH:D007249 Inflammation Progesterone 4.9815869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.2016627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.2016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007642 Keratosis Arsenic 5.0112749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 9.9812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.988314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 9.9815618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.2812371664
MESH:D007680 Kidney Neoplasms Estradiol 7.2815610895
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.7918172266
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.5517339181
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9021047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3812878042
MESH:D008107 Liver Diseases Acetaminophen 6.5519014921 19784758 11587558 12969438 16610002 19460945 16611625 12587719
MESH:D008107 Liver Diseases Arsenic 6.5511134558
MESH:D008107 Liver Diseases Phenobarbital 6.5519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 10.0516871587 17185352
MESH:D017114 Liver Failure, Acute venlafaxine 10.0519857765
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.2615890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Arsenic 14.2616368122
MESH:D008113 Liver Neoplasms Phenobarbital 14.2621047994 19482888 15975961 19812893 8742319 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 14.2620007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.2616984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.838603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.8318308698 1399818 6150874 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.8312151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4514755239
MESH:D008175 Lung Neoplasms Arsenic 3.4517306315 19168569 17976673
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4519555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.0611807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.0617203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.5119453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D001523 Mental Disorders venlafaxine 4.8816856516
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D008881 Migraine Disorders venlafaxine 4.7718803445
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D017202 Myocardial Ischemia Arsenic 9.0115371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.0112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.2616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.2616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5017484760
MESH:D009369 Neoplasms Mitoxantrone 5.2816640825
MESH:D009369 Neoplasms pirinixic acid 5.2817405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2919348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.5011399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5014600291
MESH:D009436 Neural Tube Defects Arsenic 3.4516620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.3817056641
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009771 Obsessive-Compulsive Disorder venlafaxine 5.6717503984
MESH:D010018 Osteomalacia Phenobarbital 4.3817016548
MESH:D010051 Ovarian Neoplasms Arsenic 7.9517306315
MESH:D010051 Ovarian Neoplasms Estradiol 7.9519401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.9517393432 16525653
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.4916965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.1916093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.0116905509 6392382 15371236
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.9812371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.982563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2111896295 11399792 11222880 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8015572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8920887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.6516140617
MESH:D011471 Prostatic Neoplasms Calcitriol 2.6516289102 12479363 15754350 18247401 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 2.6516740699
MESH:D011507 Proteinuria Arsenic 4.0121343184
MESH:D019310 Pseudolymphoma Phenobarbital 4.5312752131
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012640 Seizures Phenobarbital 2.693137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.846407741
MESH:D012871 Skin Diseases Arsenic 2.7519834688 15952646 18709164 16702368 17548696 16353154 17938729 6392382 17050553 16759981 17453740
MESH:D012878 Skin Neoplasms Arsenic 5.7117029826 19538983 17976673 15504454 17050553 16251483
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7116192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.3015862959 16503802
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.051399818
MESH:D013978 Tibial Fractures Estradiol 4.7219048282
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8211144890 18640142 19322015 17976673 15987713 19429237 17306315
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D014652 Vascular Diseases Arsenic 4.7517056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
KEGG:00561 Glycerolipid metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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