AutismKB 2.0

Annotation Detail for CIAO1


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Basic Information Top
Gene Symbol:CIAO1 ( CIA1,WDR39 )
Gene Full Name: cytosolic iron-sulfur protein assembly 1
Band: 2q11.2
Quick LinksEntrez ID:9391; OMIM: 604333; Uniprot ID:CIAO1_HUMAN; ENSEMBL ID: ENSG00000144021; HGNC ID: 14280
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C103303 alitretinoin alitretinoin results in decreased expression of CIAO1 mRNAdecreases expression 16648578
C095105 bexarotene bexarotene results in decreased expression of CIAO1 mRNAdecreases expression 16648578
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CIAO1 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil CIAO1 protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CIAO1 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in decreased expression of CIAO1 mRNAdecreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3114514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5514692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.5517638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D000740 Anemia Fluorouracil 9.7116511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.7111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.8015885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.8016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3216292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.0416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms alitretinoin 2.4416344269
MESH:D001943 Breast Neoplasms bexarotene 2.4416818667 16344269
MESH:D001943 Breast Neoplasms Fluorouracil 2.4419217205 16110121 15136595 16595493 18608205 18357371 16557594
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.4420435547
MESH:D001943 Breast Neoplasms Tretinoin 2.4416873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 9.0417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.0416835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.2517045692 16799960 16332177 17971768 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.251917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.3116247446
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1418695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.9816757204 18986760 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9816051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 18850075 16120746
MESH:D002386 Cataract Tretinoin 3.2617460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1016105132 17333356 17681005 17110522 16919318 15861022 11677210
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.1312621046 15668235 15340226 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 6.139407595
MESH:D003092 Colitis Tretinoin 4.1217035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2717169374 16510598 17287894 15001691 16340194 18772588 17172411 17725105 17018589 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018383874 17695437 17454858 16391804 15289873 17401013 14970324 15148649 18509181 16282729 16303861 18448328 17094418 20501625 17016601 16524972 17255274 16331619 18949393 18802399 18288408 17594712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.529211117 17551590 9664655 10589399 14991402 8800419 9224671 16925845 9125849 9142499
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.7416714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 13.7418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5116785472 17638652 15173087 16481741 16337965
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.619664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1415345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.0420067830
MESH:D005355 Fibrosis Tretinoin 10.0417994277
MESH:D005909 Glioblastoma Tretinoin 3.1917312396
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.4718337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.4716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0210048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 7.0214991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3116120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5716959395 15340226 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.4616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912878042 12200463
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 11.0416580747
MESH:D007569 Jaw Abnormalities Tretinoin 11.0415992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 6.1016144296
MESH:D007680 Kidney Neoplasms Fluorouracil 3.5716985049
MESH:D007938 Leukemia Tretinoin 2.9017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0216482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1216294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3417361223 15748426 9834237 17301526 16891316 16331271 17107899 19225113 17712046 17368321 17649720 16935935 19642359 19029980 17294898 19075265 16823087 16766008 17339181 17506722 19035177 16788101 16140955 12679006 17217047
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3818397230 16248980
MESH:D008113 Liver Neoplasms Fluorouracil 4.8217045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008175 Lung Neoplasms alitretinoin 5.1616413115
MESH:D008175 Lung Neoplasms bexarotene 5.1617849452
MESH:D008175 Lung Neoplasms Fluorouracil 5.1615246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.1611884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.5611161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 3.5919196723 15591091 19196722
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8716757204 18986760
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2417596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009369 Neoplasms alitretinoin 9.2416946489
MESH:D009369 Neoplasms Fluorouracil 9.2418600527 18239605 16928823
MESH:D009369 Neoplasms Tretinoin 9.2416594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 5.3019196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.8114600291
MESH:D009421 Nervous System Malformations Tretinoin 10.819125849
MESH:D009436 Neural Tube Defects Tretinoin 3.249142499
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4216936753
MESH:D010146 Pain Tretinoin 3.1616870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6516500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6515976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017499 Porokeratosis alitretinoin 6.5216144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3619082440 18626508
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3018286688 15538739 18722050 16160472
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4516283617 16116481
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9916192470
MESH:D012878 Skin Neoplasms Tretinoin 5.9916467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5716424979 17522103 19015929 17498489 18396642 18567086 15786421 17172411 16951190 19084572
MESH:D013274 Stomach Neoplasms Tretinoin 2.5717261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2617045167 16026305
MESH:D014062 Tongue Neoplasms Fluorouracil 10.8616280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.8616051514
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 10.4816803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.4816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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