AutismKB 2.0

Annotation Detail for FOXP2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FOXP2 ( CAGH44,DKFZp686H1726,SPCH1,TNRC10 )
Gene Full Name: forkhead box P2
Band: 7q31.1
Quick LinksEntrez ID:93986; OMIM: 605317; Uniprot ID:FOXP2_HUMAN; ENSEMBL ID: ENSG00000128573; HGNC ID: 13875
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
PSYCH
schizophrenia
Autism
No data
Desease Name
Speech-language disorder-1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of FOXP2 mRNAaffects expression 20382639
D003024 Clozapine Clozapine results in increased expression of FOXP2 mRNAincreases expression 17266109
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in decreased expression of FOXP2 mRNAaffects cotreatment|decreases expression 17183730
D008345 Manganese Manganese results in increased expression of FOXP2 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of FOXP2 mRNAincreases expression 17175027
D010622 Phencyclidine Phencyclidine results in increased expression of FOXP2 mRNAincreases expression 17266109
C006253 pirinixic acid pirinixic acid results in increased expression of FOXP2 mRNAincreases expression 18301758
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in decreased expression of FOXP2 mRNAaffects cotreatment|decreases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.828875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000380 Agranulocytosis Clozapine 5.3612649775 16160616 14617031
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000756 Anemia, Sideroblastic Manganese 11.8516910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.8516910769
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001072 Apraxias marker/mechanism 17033973
MESH:D001321 Autistic Disorder marker/mechanism 15108192 17033973
MESH:D001321 Autistic Disorder Valproic Acid 1.9920603192 17688650 17507914 17157402 15238991 19232924 18316065 19460635 18940202 18396377 18558336 18177632 16609825 18775368 18985861
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8820889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D003072 Cognition Disorders Clozapine 5.2717123785
MESH:D019465 Craniofacial Abnormalities marker/mechanism 17033973
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 16575769 17688650
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 3.0216402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.9315331141
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.231733752 19641884
MESH:D050171 Dyslipidemias Clozapine 4.3516402076
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.463659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0418234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.806254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1220426865
MESH:D005234 Fatty Liver pirinixic acid 8.5419236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 8.5414986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.418888407 18558336
MESH:D005909 Glioblastoma Manganese 4.0617043766
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3019176532 18467677 19772884 16221962
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006948 Hyperkinesis Clozapine 5.2516046005
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9316612254
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D008064 Lipidoses Clozapine 4.1317567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.8920007298 16377806 15890375
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D020149 Manganese Poisoning Manganese 5.9019453300 16551646 16568477
MESH:D001523 Mental Disorders Clozapine 4.2816856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.6119142101
MESH:D008881 Migraine Disorders Valproic Acid 3.3618803445 18765137
MESH:D009069 Movement Disorders Manganese 5.2716551646
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009410 Nerve Degeneration Manganese 4.4616551646
MESH:D009436 Neural Tube Defects Valproic Acid 3.2716359493 8888407
MESH:D009765 Obesity Clozapine 4.8719142110 18515891
MESH:D009765 Obesity pirinixic acid 4.8720558911
MESH:D010300 Parkinson Disease Manganese 3.4411181820
MESH:D020734 Parkinsonian Disorders Manganese 4.7016140633
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1720603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.9212752131 11422049
MESH:D011618 Psychotic Disorders Clozapine 4.3515331141
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Clozapine 3.9217667964 17123785 20168265 19369910 11763009 20521320 20452607 11151749 20580759 18806925 18855531 16141801 20107430 17726453 20521326
MESH:D012559 Schizophrenia Valproic Acid 3.9215737665 19110320
MESH:D012640 Seizures Valproic Acid 2.891511512 11738929 14763951 16876388 11044598 15475178 17978042 3137016
MESH:D056730 Silver-Russell Syndrome marker/mechanism 17033973
OMIM:602081 SPEECH-LANGUAGE DISORDER 1 marker/mechanism
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D015430 Weight Gain Clozapine 4.6820564506 20521320 16141801 20107430 16402076 17502770
MESH:D015431 Weight Loss Clozapine 5.4117933447
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28242
    • Releated gene ID Related gene Name
    PA26692CNTNAP2
    No data
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved