AutismKB 2.0

Annotation Detail for RECQL5


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Basic Information Top
Gene Symbol:RECQL5 ( FLJ90603,RECQ5 )
Gene Full Name: RecQ protein-like 5
Band: 17q25
Quick LinksEntrez ID:9400; OMIM: 603781; Uniprot ID:RECQ5_HUMAN; ENSEMBL ID: ENSG00000108469; HGNC ID: 9950
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RECQL5 mRNAaffects expression 21346803
D003561 Cytarabine Cytarabine results in decreased expression of RECQL5 mRNAdecreases expression 19194470
C014347 decitabine decitabine results in decreased expression of RECQL5 mRNAdecreases expression 19194470
C006253 pirinixic acid pirinixic acid results in decreased expression of RECQL5 mRNAdecreases expression 17426115
D012643 Selenium Selenium results in increased expression of RECQL5 mRNAincreases expression 19244175
D014212 Tretinoin Tretinoin results in decreased expression of RECQL5 mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.2516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3216292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.0819483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.0816206674 16197459
MESH:D001943 Breast Neoplasms decitabine 2.2719208741 18320071
MESH:D001943 Breast Neoplasms Tretinoin 2.2716873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1216705839
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.121917145
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.0219215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.0216096774 16051514
MESH:D002386 Cataract Tretinoin 3.2617460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.916135515
MESH:D002471 Cell Transformation, Neoplastic Cytarabine 7.918243401
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tretinoin 2.789407595
MESH:D003092 Colitis Selenium 10.9217936198
MESH:D003092 Colitis Tretinoin 10.9217035595
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839125849 14991402 16925845 9211117 8800419 9664655 17551590 9224671 10589399 9142499
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.4418551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.1818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1815131321
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004489 Edema, Cardiac Tretinoin 4.9918230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.6419294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3016569247
MESH:D005124 Eye Abnormalities Tretinoin 3.819664655 16938888
MESH:D005234 Fatty Liver pirinixic acid 3.0920131406 19236843
MESH:D005355 Fibrosis Tretinoin 3.9317994277
MESH:D005909 Glioblastoma Tretinoin 3.1917312396
MESH:D006258 Head and Neck Neoplasms decitabine 8.5119215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.5116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0414991402 9664655
MESH:D006333 Heart Failure pirinixic acid 7.5520558911
MESH:D006333 Heart Failure Selenium 7.5517162251
MESH:D006529 Hepatomegaly pirinixic acid 3.4118467677 19176532 19772884 16221962
MESH:D006689 Hodgkin Disease Cytarabine 4.7016200630
MESH:D006930 Hyperalgesia Tretinoin 3.4616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007248 Infertility, Male decitabine 3.4017581917
MESH:D007251 Influenza, Human Selenium 4.7216624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2315992940 17551590
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2416705839
MESH:D007938 Leukemia decitabine 6.8919235587 18980019
MESH:D007938 Leukemia Tretinoin 6.8917143497
MESH:D007951 Leukemia, Myeloid decitabine 10.6718454857 19117987 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 10.6716932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.1218704418 18460780 19387464 19010910 18206229 17679729
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.1217596541 19850784 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9818055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3416140955 19029980 19642359 17301526 16891316 19225113 19035177 17361223 17712046 12679006 17649720 15748426 17107899 16788101 9834237 16331271 16823087 17368321 17294898 19075265 17339181 16935935 17506722 17217047 16766008
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.4216248980 18397230
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.747678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.7415890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.722876786 2876784 6135515
MESH:D008223 Lymphoma decitabine 3.6419470736
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9515318939
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma decitabine 3.5616505122 17785578
MESH:D008545 Melanoma Tretinoin 3.5616752155
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D008654 Mesothelioma Selenium 2.8915107826
MESH:D009101 Multiple Myeloma decitabine 3.5618172295
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009190 Myelodysplastic Syndromes decitabine 8.0218608210 19157545 16882708 19010910
MESH:D009190 Myelodysplastic Syndromes Tretinoin 8.0217596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.3218551238 7678174
MESH:D009369 Neoplasms decitabine 9.0719116145 19470736 17925555
MESH:D009369 Neoplasms pirinixic acid 9.0717405874
MESH:D009369 Neoplasms Tretinoin 9.0716594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.169125849
MESH:D009436 Neural Tube Defects Tretinoin 3.249142499
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7416049721
MESH:D010051 Ovarian Neoplasms decitabine 5.2319331143 19259094
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2316936753
MESH:D010146 Pain Tretinoin 3.1616870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.6919294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6915976015
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytarabine 4.6021297632
MESH:D055728 Primary Myelofibrosis decitabine 5.1517616702
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012208 Rhabdomyosarcoma decitabine 12.1419155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 12.1416283617 16116481
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7418551238
MESH:D012878 Skin Neoplasms Tretinoin 2.7316467112
MESH:D013274 Stomach Neoplasms decitabine 2.6119037991
MESH:D013274 Stomach Neoplasms Tretinoin 2.6117261132
MESH:D013964 Thyroid Neoplasms decitabine 8.1117967635
MESH:D013964 Thyroid Neoplasms Tretinoin 8.1117045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0916051514
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.5216049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.5219087683 17616700
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7810091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9816129372
MESH:D014604 Uveal Neoplasms decitabine 14.6317785578
MESH:D014604 Uveal Neoplasms Tretinoin 14.6316752155
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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