AutismKB 2.0

Annotation Detail for PIGS


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Basic Information Top
Gene Symbol:PIGS ( DKFZp686K20216,FLJ45226 )
Gene Full Name: phosphatidylinositol glycan anchor biosynthesis, class S
Band: 17q11.2
Quick LinksEntrez ID:94005; OMIM: 610271; Uniprot ID:PIGS_HUMAN; ENSEMBL ID: ENSG00000087111; HGNC ID: 14937
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00563Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of proteins
No data
No data
Pathway IDPathway Name
500547Attachment of GPI anchor to uPAR
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PIGS mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PIGS mRNAaffects expression 21346803
D016572 Cyclosporine Cyclosporine results in decreased expression of PIGS mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of PIGS mRNAdecreases expression 18042831
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PIGS mRNAaffects cotreatment|increases expression 17183730
C041786 palm oil palm oil results in decreased expression of PIGS mRNAdecreases expression 18042831
C066340 tolcapone tolcapone binds to PIGS proteinaffects binding 19783845
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PIGS mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.828875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.6711080934
MESH:D000544 Alzheimer Disease tolcapone 3.3220150427
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001321 Autistic Disorder Valproic Acid 1.9917157402 15238991 18316065 18985861 19232924 20603192 18396377 16609825 19460635 18940202 17688650 18177632 18558336 17507914 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 3.1817594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D001943 Breast Neoplasms Dietary Fats 2.2620435547
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0516705839
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.116135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1112371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D003866 Depressive Disorder tolcapone 4.477768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 5.1210440460
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.5721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.5721346803 18551238
MESH:D056486 Drug-Induced Liver Injury tolcapone 9.5719783845 16604736
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.5719641884 1733752
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.7711455177
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.293922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.807562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 6.3219578428
MESH:D005234 Fatty Liver Cyclosporine 14.5919224547
MESH:D005234 Fatty Liver Dietary Fats 14.5917967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Valproic Acid 14.5914986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.418888407 18558336
MESH:D005355 Fibrosis Cyclosporine 9.7312168785 12639820
MESH:D005355 Fibrosis Dietary Fats 9.7318296743
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9316612254
MESH:D007249 Inflammation Dietary Fats 2.5420412841
MESH:D007333 Insulin Resistance Dietary Fats 3.2518457598 11836018
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.5716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.5716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.5712371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1817596541 16294345
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9918296743
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.227678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.682876786 6135515 2876784
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3618803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.507678174 18551238
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009436 Neural Tube Defects Valproic Acid 3.2716359493 8888407
MESH:D009765 Obesity Dietary Fats 2.3321332399 18457598 20518802 17217161 11836018 19632207 18674790 20132043 16723640
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6616049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6616049721
MESH:D010300 Parkinson Disease tolcapone 3.678635184 11586115 1977408 20334432 9305320 9333106 9708959 11432539 9591521 9754991 20216409 19783845 11746615 8739811 18328768 11793426 19578428 16758261 7566641 10651109 17089403
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1720603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.9212752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 10.7518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.7518551238
MESH:D012640 Seizures Valproic Acid 10.751511512 3137016 14763951 17978042 11738929 11044598 16876388 15475178
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 6.3219578428
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2816049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014820 Vitiligo tolcapone 5.4710573327
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
KEGG:00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
KEGG:01100 Metabolic pathways
REACT:17015 Metabolism of proteins
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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