AutismKB 2.0

Annotation Detail for GRAP2


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Basic Information Top
Gene Symbol:GRAP2 ( GADS,GRAP-2,GRB2L,GRBLG,GRID,GRPL,GrbX,Grf40,Mona,P38 )
Gene Full Name: GRB2-related adaptor protein 2
Band: 22q13.1
Quick LinksEntrez ID:9402; OMIM: 604518; Uniprot ID:GRAP2_HUMAN; ENSEMBL ID: ENSG00000100351; HGNC ID: 4563
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04660T cell receptor signaling pathway
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200129JNK signaling in the CD4+ TCR pathway
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200062TCR signaling in naive CD8+ T cells
200022TCR signaling in naive CD4+ T cells
Pathway IDPathway Name
P00053T cell activation
P00047PDGF signaling pathway
Pathway IDPathway Name
500484CD28 co-stimulation
500481Generation of second messenger molecules
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1923Generalized anxiety disorder
2051Leukemia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of GRAP2 mRNAaffects expression 17331233
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of GRAP2 mRNAincreases expression 15963578
D003907 Dexamethasone Dexamethasone results in increased expression of GRAP2 mRNAincreases expression 12782123
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D001169 Arthritis, Experimental Dexamethasone 3.7817659584
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.4316227642 16097048 15721981 16011737 15700767 16050911 15673190 3786805 10355542 16192424 16124888 18705752
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8618788625
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5515824018
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.2917728286
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 4.0512438553
MESH:D003967 Diarrhea Dexamethasone 4.287237001
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.1316177239 11566570 19085960 6623471 9327722 19336974 10915739 7179309 17522070 15027814 2869522 6884620 21278145 10092053 15968718 15998439 7440962 7120509 4309450 3786805 16227642 3732212
MESH:D004485 Eczema Dexamethasone 5.0412438553
MESH:D004487 Edema Dexamethasone 3.8819703484
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.6512631006 16045604 12795759 61145 15959796 19224547 17595544 16239168
MESH:D005355 Fibrosis Carbon Tetrachloride 4.1018705752
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1819900420 19110552
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.197520565
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.2716899240
MESH:D006973 Hypertension Dexamethasone 3.0617042910
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.7415338365
MESH:D007249 Inflammation Dexamethasone 3.0711099482 8960868
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0217174718 17157831 11408273 16943688 16221502 16239168 21278145 11903743 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.7616192424 17922224 18395914 17481882 17714472 17869086 15818738 12898905 12632512 12632514 17631135 18472332 18376398 17761835 18412020 14620537 18251166 16136751 18166357 18006644 15876570 14748882 12586293 18472094 17976157 17823541 12609069 12546737 18429990 17708605 16116963 18277467 18395095 18210741 14716833 15925388 15052691 15730626 15650968 12666154 18187930 12649538 16011737 16248980 15123356 17698563 17900296 15673190 17944888 14512876 17766677 15338365 18317297 12445418 18156304 15370692 16033810 17805973 16097048 15931870 18263696 12389079 18481824 16015684 12741479 14716496 15893842 16638106 15057751 17557913 16027843 18054572 15996030 18339082 15959796 13678700 17565644 18279442 17640975 18205269 18418968 12958196 15362042 18705752 18420326 11481614 17525996 17721639 10355542 14724832 20821823 12667390 12445421
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.7616718785
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1616964402 16246199 15720792 17285989 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.8215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.1414706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.3519294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8615583823 12014681
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.6717365036
MESH:D008175 Lung Neoplasms Dexamethasone 2.2715824018 11195469
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.3216966607 18303189 16166281
MESH:D009101 Multiple Myeloma Dexamethasone 3.8115867202 16118317 15744524
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.769809623
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.5510923243
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.7621297632
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1617975199 17365031 15814490 17322281
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.5418379247 11700416
MESH:D013272 Stomach Diseases Dexamethasone 5.0615472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.9615138204
MESH:D014605 Uveitis Dexamethasone 5.681336536
Pathway ID Pathway Name
REACT:6900 Signaling in Immune system
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28959
    • No data
    No data
    Releated drug ID Related drug Name
    PA10804imatinib
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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