AutismKB 2.0

Annotation Detail for PEX16


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Basic Information Top
Gene Symbol:PEX16 ( - )
Gene Full Name: peroxisomal biogenesis factor 16
Band: 11p11.2
Quick LinksEntrez ID:9409; OMIM: 603360; Uniprot ID:PEX16_HUMAN; ENSEMBL ID: ENSG00000121680; HGNC ID: 8857
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
H00205Zellweger syndrome spectrum
Peroxisomal diseases
Genetic disorders
Desease IDDesease Name
2032Kidney disease
2126Encephalopathies
No data
No data
Desease Name
Zellweger syndrome, complementation group 9
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PEX16 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PEX16 mRNAaffects expression 17562736
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of PEX16 mRNAdecreases expression 17490981
D004041 Dietary Fats Dietary Fats results in decreased expression of PEX16 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of PEX16 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PEX16 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of PEX16 mRNAincreases expression 18301758
18445702
17426115
D014810 Vitamin E Vitamin E results in decreased expression of PEX16 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.2515238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2916050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.9216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.923084413
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.956135515
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.9418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9414725611 14550746 19923254 12594235 16781746 12392966 11461765 10663392 16109766 19164858 12958197 18713872 2444490 11529661 11287661 11739529 17522070 17906064 19085960 12540782 19416960 19420014 16177239 11743745 14986274 15619225 18071297 12153990 19370779 10774834 11421492 17562736 16227642 15968718 19739265 16485898 11834606 16393943 10915739 16081117 12705907
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6518367378
MESH:C538011 Eales disease Vitamin E 5.159068938
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D005234 Fatty Liver Dietary Fats 8.6517967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver pirinixic acid 8.6520131406 19236843
MESH:D005355 Fibrosis Dietary Fats 3.8818296743
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1216080930
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3518467677 19176532 16221962 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7816863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.4114716179
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.9221332399
MESH:D007249 Inflammation Dietary Fats 2.5520412841
MESH:D007251 Influenza, Human Vitamin E 4.6616624496
MESH:D007333 Insulin Resistance Dietary Fats 7.8218457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.8216306350
MESH:D007674 Kidney Diseases Acetaminophen 6.4512587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 6.4512488133
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2116705839
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0118296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4516169303
MESH:D008107 Liver Diseases Acetaminophen 1.6819014921 16610002 12969438 19784758 19460945 12587719 16611625 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.707678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.7016377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.702876786 2876784 6135515
MESH:D008171 Lung Diseases Vitamin E 3.3516863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2618551238 7678174
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity Dietary Fats 4.6218457598 17217161 20518802 21332399 18674790 19632207 16723640 11836018 20132043
MESH:D009765 Obesity pirinixic acid 4.6220558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D018901 Peroxisomal Disorders marker/mechanism
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2615084515
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D020521 Stroke Vitamin E 3.7416517955
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D015430 Weight Gain Dietary Fats 3.9916723640
Pathway ID Pathway Name
KEGG:04146 Peroxisome
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33199
    • No data
    Releated disease ID Related disease Name
    PA446115Zellweger Syndrome
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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