AutismKB 2.0

Annotation Detail for MED21


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Basic Information Top
Gene Symbol:MED21 ( SRB7,SURB7 )
Gene Full Name: mediator complex subunit 21
Band: 12p12
Quick LinksEntrez ID:9412; OMIM: 603800; Uniprot ID:MED21_HUMAN; ENSEMBL ID: ENSG00000152944; HGNC ID: 11473
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MED21 mRNAincreases expression 18648102
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of MED21 mRNAaffects expression 17331233
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MED21 mRNAdecreases expression 15336504
D002945 Cisplatin MED21 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
C009277 sodium arsenate sodium arsenate results in decreased expression of MED21 mRNAdecreases expression 12727804
C017947 sodium arsenite sodium arsenite results in increased expression of MED21 mRNAincreases expression 20308225
C017947 sodium arsenite sodium arsenite results in decreased expression of MED21 mRNAdecreases expression 12727804
C017947 sodium arsenite sodium arsenite results in increased expression of MED21 mRNAincreases expression 18812580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 4.2812690470 15814532 17670903
MESH:D000230 Adenocarcinoma Cisplatin 2.8111798837 17638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.2215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.4217306315 16712894
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.4114601052
MESH:D001943 Breast Neoplasms Cisplatin 2.7719526202 18382427
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.903581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.9017982673
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.9016507464 17306315 15276417
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1216685392 12023789
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.136189445 18337622 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.1318572023
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.447505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.4419524636 20056578
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.389022650 19486331
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D019465 Craniofacial Abnormalities sodium arsenate 2.7310525206
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2112868966 8970840 18759878 11906362 8156756 11298694 14531868 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.481440618 8291058 18692083 16192314 18289764 9022650 7440962 9653073 11289319 6482804 9328219 6679447 18648102
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 4.4818186108
MESH:D004362 Drug Toxicity Cisplatin 4.0819839026 12649298 12231392 15033597
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.863581430
MESH:D004938 Esophageal Neoplasms Cisplatin 4.8615464296 17638652 16481741 16785472 15173087
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.1416452187
MESH:D018149 Glucose Intolerance sodium arsenate 5.4319446573
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.9115464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.5819898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.6915464296
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006689 Hodgkin Disease Cisplatin 8.5016200630 16170182
MESH:D006689 Hodgkin Disease sodium arsenite 8.5012676792
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D007248 Infertility, Male sodium arsenite 3.1915346721 12646999
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.549022650 8074119
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.6615464296
MESH:D007674 Kidney Diseases Cisplatin 6.9019839026 12649298 12231392 18289764 15190930
MESH:D007674 Kidney Diseases sodium arsenite 6.9020008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.3111231351
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3815034207 9327722
MESH:D008113 Liver Neoplasms sodium arsenite 2.4615276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.713712494 6587162 598648 1399818
MESH:D008171 Lung Diseases sodium arsenite 3.3719095001
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.4417365036
MESH:D008175 Lung Neoplasms Cisplatin 2.7817225452 11798837 6189445
MESH:D008175 Lung Neoplasms sodium arsenite 2.7817077188 16712894 17306315 15276417 19931552
MESH:D008545 Melanoma Cisplatin 3.6818505091 11135225 16248763 18332650 17761969 12883367 16809738 12374674 17023156 18176117 16432458 15577323 12393984
MESH:D008545 Melanoma sodium arsenite 3.6816487513 19082730
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.2415990972
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.8516966607 18303189 16166281
MESH:D008654 Mesothelioma Cisplatin 6.8517638057
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 5.1818186108
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009369 Neoplasms Cisplatin 5.7616773208
MESH:D009369 Neoplasms sodium arsenite 5.7611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0820056578
MESH:D009395 Nephritis, Interstitial Cisplatin 5.0115464296
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 13.396679447
MESH:D009436 Neural Tube Defects sodium arsenate 13.3911749123 10525206 19446573 18186108
MESH:D009436 Neural Tube Defects sodium arsenite 13.3912854658
MESH:D009447 Neuroblastoma Cisplatin 3.598761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.168761367
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.726482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010051 Ovarian Neoplasms Cisplatin 5.3519769630 15464296 17225452 6897625
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.3515276417 17306315
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0819003803
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.6915464296
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.3110923243
MESH:D010997 Pleural Neoplasms Cisplatin 5.8617638057
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2516039940
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1317365031 17322281 15814490 17975199
MESH:D051437 Renal Insufficiency Cisplatin 4.8215464296
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.8114601052
MESH:D012878 Skin Neoplasms sodium arsenite 6.2619524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.268532709
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.8615464296
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0412854658
MESH:D013274 Stomach Neoplasms Cisplatin 2.3318396642 17522103 15958060
MESH:D013736 Testicular Neoplasms Cisplatin 4.9815464296 17225452
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.126582329 6587162 3712494 1399818 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 9.018074119
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 9.0115464296 17225452 12973940
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 9.0116452187 17306315 11723127 16712894
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 10.6416803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 10.6411813266
MESH:D014625 Vaginal Neoplasms Cisplatin 5.0315577323
MESH:D014652 Vascular Diseases sodium arsenite 4.8917056641
MESH:D014839 Vomiting Cisplatin 5.2411897121
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
REACT:27166 Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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