AutismKB 2.0

Annotation Detail for TJP2


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Basic Information Top
Gene Symbol:TJP2 ( MGC26306,X104,ZO2 )
Gene Full Name: tight junction protein 2 (zona occludens 2)
Band: 9q21.11
Quick LinksEntrez ID:9414; OMIM: 607709; Uniprot ID:ZO2_HUMAN; ENSEMBL ID: ENSG00000119139; HGNC ID: 11828
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04530Tight junction
hsa05110Vibrio cholerae infection
Pathway IDPathway Name
Apoptosis
Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
No data
Pathway IDPathway Name
500272Apoptotic cleavage of cell adhesion proteins
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Hypercholanemia, familial
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TJP2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TJP2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of TJP2 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of TJP2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TJP2 mRNAaffects expression 16483693
C015001 arsenite arsenite results in increased expression of TJP2 mRNAincreases expression 18191166
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TJP2 mRNAincreases expression 17879257
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TJP2 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in decreased expression of TJP2 mRNAdecreases expression 20106945
D005419 Flavonoids Flavonoids results in increased expression of TJP2 mRNAincreases expression 18035473
D015735 Mifepristone Mifepristone inhibits the reaction [Progesterone results in decreased expression of TJP2 protein]decreases expression|decreases reaction 17478549
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TJP2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of TJP2 mRNAincreases expression 18301758
D011374 Progesterone Mifepristone inhibits the reaction [Progesterone results in decreased expression of TJP2 protein]decreases expression|decreases reaction 17478549
D011374 Progesterone Progesterone results in decreased expression of TJP2 proteindecreases expression 17478549
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TJP2 mRNAdecreases expression 17101203
20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TJP2 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9315322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0020464547 20127859
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.703712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.706695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.1816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.1816835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.121440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.9519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4317868700
MESH:D001930 Brain Injuries Progesterone 4.3315665606 15845082 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8317474063 20146248
MESH:D001943 Breast Neoplasms Progesterone 1.8316175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.613581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.613084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.707296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3916120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.316135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.317505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.3120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.3112371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.6219486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.6219486331
MESH:D002779 Cholestasis pirinixic acid 13.6219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1212621046 15340226 16354765 15668235 8697196
MESH:D003110 Colonic Neoplasms arsenite 2.5915037631
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.1418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.1418551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8711298694 12868966 8970840 8156756 14531868 2524372 18759878 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.553621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.5617187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.1721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.1721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.1718692083 1440618 11289319 16192314 18648102 7440962 9022650 6679447 9328219 18289764 9653073 8291058 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.1710663392 17522070 11461765 16109766 12594235 19420014 17906064 15968718 14550746 12392966 19164858 19085960 18071297 16177239 12540782 15619225 16781746 16227642 16393943 11834606 11287661 16081117 19416960 12958197 18713872 14986274 16485898 11421492 11529661 11743745 17562736 19739265 19370779 19923254 14725611 12153990 2444490 12705907 11739529 10915739 10774834
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.1720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.8417692515
MESH:D004715 Endometriosis Mifepristone 15.6416134523
MESH:D004715 Endometriosis Progesterone 15.6416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 15.6410568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.263581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.2616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver arsenite 13.4618296743
MESH:D005234 Fatty Liver Cyclosporine 13.4619224547
MESH:D005234 Fatty Liver pirinixic acid 13.4619236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D005355 Fibrosis arsenite 15.2318296743
MESH:D005355 Fibrosis Cyclosporine 15.2312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.2320067830
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006529 Hepatomegaly pirinixic acid 8.5018467677 19772884 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.5012621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.148697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
OMIM:607748 HYPERCHOLANEMIA, FAMILIAL marker/mechanism
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118670907 18850075
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4715869954
MESH:D007249 Inflammation Flavonoids 8.5017296493
MESH:D007249 Inflammation Progesterone 8.5015869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5012878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.898314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.1316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.1316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.136582329
MESH:D007680 Kidney Neoplasms Cyclosporine 18.1312371664
MESH:D008103 Liver Cirrhosis arsenite 3.4518296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.239327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1512878042
MESH:D008107 Liver Diseases Acetaminophen 1.6412587719 12969438 19460945 16610002 19784758 11587558 16611625 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2917185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.827678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.8221137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 10.8215890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.8216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.962876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.96598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9612151625
MESH:D008175 Lung Neoplasms arsenite 3.4616809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4617053015 20464547 20869020 18520028 20135361 20064080 6695378 18569708 18816296
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4611884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.9017203775 11408345
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.6318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.6318551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.493581430
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9011141357
MESH:D009369 Neoplasms pirinixic acid 4.9017405874
MESH:D009389 Neovascularization, Pathologic arsenite 4.4915738583
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.956679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.3712819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.3716049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.376482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010051 Ovarian Neoplasms Mifepristone 5.2616525653
MESH:D010051 Ovarian Neoplasms Progesterone 5.2617393432 16525653
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9617292933
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8718045962
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5516192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.3616503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.926582329 1399818 6587162 3712494 7505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.0716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.0716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.078074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.0717053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.2710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.2710091137
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
REACT:578 Apoptosis
KEGG:04530 Tight junction
KEGG:05110 Vibrio cholerae infection
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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