Annotation Detail for DDX23
Basic Information
Top
| Pathway ID | Pathway Name |
|---|
| hsa03040 | Spliceosome |
| Pathway ID | Pathway Name |
|---|
| mRNA Processing |
| Gene Expression |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C016403 |
2,4-dinitrotoluene |
2,4-dinitrotoluene affects the expression of DDX23 mRNA | affects expression | 21346803
|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene affects the expression of DDX23 mRNA | affects expression | 21346803
|
| D001564 |
Benzo(a)pyrene |
Benzo(a)pyrene results in increased expression of DDX23 mRNA | increases expression | 20504355
|
| D017239 |
Paclitaxel |
DDX23 protein affects the susceptibility to Paclitaxel | affects response to substance | 16217747
|
| D014747 |
Vinblastine |
DDX23 protein affects the susceptibility to Vinblastine | affects response to substance | 16217747
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000230 |
Adenocarcinoma |
|
Benzo(a)pyrene |
2.05 | 20127859 20464547 |
| MESH:D000236 |
Adenoma |
|
Benzo(a)pyrene |
2.84 | 6695378 |
| MESH:D017544 |
Aortic Aneurysm, Abdominal |
|
Benzo(a)pyrene |
4.56 | 19183758 |
| MESH:D001859 |
Bone Neoplasms |
|
Paclitaxel |
4.97 | 15867366 |
| MESH:D001943 |
Breast Neoplasms |
|
Benzo(a)pyrene |
2.31 | 17474063 20146248 |
| MESH:D001943 |
Breast Neoplasms |
|
Paclitaxel |
2.31 | 16273361 18234424 18323546 18223236 16244791 11325840 15136595 16115903 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,4-dinitrotoluene |
4.91 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
4.91 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Paclitaxel |
4.91 | 16313753 |
| MESH:D002292 |
Carcinoma, Renal Cell |
|
Vinblastine |
3.92 | 1485588 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
Benzo(a)pyrene |
2.13 | 20419170 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
3.00 | 6135515 |
| MESH:D015179 |
Colorectal Neoplasms |
|
Paclitaxel |
3.10 | 18802399 |
| MESH:D015179 |
Colorectal Neoplasms |
|
Vinblastine |
3.10 | 18802399 |
| MESH:D003490 |
Cyanosis |
|
2,4-dinitrotoluene |
12.56 | 18551238 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
12.56 | 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,4-dinitrotoluene |
4.13 | 18551238 21346803 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
4.13 | 21346803 18551238 |
| MESH:D004938 |
Esophageal Neoplasms |
|
Benzo(a)pyrene |
4.89 | 16530937 |
| MESH:D004938 |
Esophageal Neoplasms |
|
Paclitaxel |
4.89 | 16481741 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Benzo(a)pyrene |
2.82 | 20471113 |
| MESH:D006689 |
Hodgkin Disease |
|
Vinblastine |
4.35 | 18180244 18501091 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,4-dinitrotoluene |
8.39 | 16705839 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
8.39 | 16705839 |
| MESH:D008080 |
Liposarcoma |
|
Paclitaxel |
5.23 | 17353645 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
4.86 | 7678174 |
| MESH:D008113 |
Liver Neoplasms |
|
Benzo(a)pyrene |
4.86 | 21137059 20195826 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.74 | 2876786 2876784 6135515 |
| MESH:D008175 |
Lung Neoplasms |
|
Benzo(a)pyrene |
1.57 | 20464547 6695378 18520028 20135361 17053015 20869020 18816296 18569708 20064080 |
| MESH:D008228 |
Lymphoma, Non-Hodgkin |
|
Paclitaxel |
4.40 | 14749477 |
| MESH:D008545 |
Melanoma |
|
Paclitaxel |
4.05 | 12040289 16342250 12025231 |
| MESH:D008545 |
Melanoma |
|
Vinblastine |
4.05 | 15577320 12374674 15577323 18332650 18505091 18176117 16248763 16432458 16809738 17761969 |
| MESH:D009062 |
Mouth Neoplasms |
|
Benzo(a)pyrene |
3.46 | 16381670 |
| MESH:D009101 |
Multiple Myeloma |
|
Paclitaxel |
3.93 | 14749477 |
| MESH:D009336 |
Necrosis |
|
2,4-dinitrotoluene |
12.21 | 18551238 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
12.21 | 18551238 7678174 |
| MESH:D009362 |
Neoplasm Metastasis |
|
Paclitaxel |
3.37 | 15867366 |
| MESH:D009369 |
Neoplasms |
|
Benzo(a)pyrene |
2.31 | 11141357 |
| MESH:D009503 |
Neutropenia |
|
Vinblastine |
4.97 | 17378895 |
| MESH:D009784 |
Occupational Diseases |
|
2,4-dinitrotoluene |
10.06 | 12819281 16049721 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
10.06 | 16049721 |
| MESH:D010014 |
Osteolysis |
|
Paclitaxel |
5.52 | 15867366 |
| MESH:D010051 |
Ovarian Neoplasms |
|
Paclitaxel |
3.07 | 11161223 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Benzo(a)pyrene |
3.32 | 17292933 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Paclitaxel |
3.32 | 16729912 17136230 17172428 16356831 |
| MESH:D012640 |
Seizures |
|
2,4-dinitrotoluene |
6.65 | 18551238 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
6.65 | 18551238 |
| MESH:D012878 |
Skin Neoplasms |
|
Benzo(a)pyrene |
2.51 | 10029692 19755658 |
| MESH:D013274 |
Stomach Neoplasms |
|
Benzo(a)pyrene |
2.65 | 20155912 2093021 |
| MESH:D013274 |
Stomach Neoplasms |
|
Paclitaxel |
2.65 | 18396642 18506536 |
| MESH:D024801 |
Tauopathies |
|
Paclitaxel |
5.35 | 16930453 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,4-dinitrotoluene |
8.94 | 16049721 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
8.94 | 16049721 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
Benzo(a)pyrene |
8.94 | 17053015 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,4-dinitrotoluene |
13.86 | 10091137 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
13.86 | 10091137 |
| MESH:D014625 |
Vaginal Neoplasms |
|
Vinblastine |
5.53 | 15577323 |
Related Diseases/Disorders