AutismKB 2.0

Annotation Detail for TNFRSF8


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Basic Information Top
Gene Symbol:TNFRSF8 ( CD30,D1S166E,Ki-1 )
Gene Full Name: tumor necrosis factor receptor superfamily, member 8
Band: 1p36.22
Quick LinksEntrez ID:943; OMIM: 153243; Uniprot ID:TNR8_HUMAN; ENSEMBL ID: ENSG00000120949; HGNC ID: 11923
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04060Cytokine-cytokine receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1704Common variable immunodeficiency
1781Rheumatoid arthritis
1809HIV infection
1930Graves' disease
2091Hypertension
2051Leukemia
2100Hepatitis C
2133Pyelonephritis
2146Lupus erythematosus
2161Hodgkin's disease
2174Chronic rejection of renal transplant
2233Cirrhosis
2239Lymphoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TNFRSF8 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in increased expression of TNFRSF8 mRNAincreases expression 19962721
C006632 arsenic trioxide arsenic trioxide results in decreased expression of TNFRSF8 mRNAdecreases expression 19730151
D002392 Catechin Catechin results in decreased expression of TNFRSF8 mRNAdecreases expression 15465739
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNFRSF8 mRNA]decreases reaction|increases expression 11007951
D005665 Furosemide Furosemide affects the expression of TNFRSF8 mRNAaffects expression 17497460
D007530 Isoflurane Isoflurane results in decreased expression of TNFRSF8 mRNAdecreases expression 16978161
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of TNFRSF8 mRNAincreases expression 12057914
D005996 Nitroglycerin Nitroglycerin results in decreased expression of TNFRSF8 mRNAdecreases expression 12102619
C006253 pirinixic acid NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of TNFRSF8 mRNA]decreases expression|increases reaction 17950772
C006253 pirinixic acid pirinixic acid results in decreased expression of TNFRSF8 mRNAdecreases expression 17950772
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNFRSF8 mRNA]decreases reaction|increases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TNFRSF8 mRNAincreases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TNFRSF8 mRNAincreases expression 18684927
15310856
14718646
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.5518653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 9.5518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3111798837 19825857
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4317306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D020261 Arsenic Poisoning Arsenic 2.9016835338 12569548 16251483 18414634
MESH:D050197 Atherosclerosis Arsenic 3.3319371607 12928151
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.1216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.1219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6617687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.2816507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.2814691202 11135700 15073043 16217749 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7215504454 17687452 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2118640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.5415738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.4318022660 16973168
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515668235 15340226 12621046 8697196 16354765
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5120055451 10048152 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004417 Dyspnea Furosemide 5.1616935035
MESH:D004487 Edema Furosemide 12.3511834646
MESH:D004487 Edema pirinixic acid 12.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.3512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.5917637181 15821434 15328337
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3412903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver arsenic trioxide 8.1915073043
MESH:D005234 Fatty Liver pirinixic acid 8.1919236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005334 Fever Lipopolysaccharides 4.1411852909 9205823
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005534 Foot Diseases Arsenic 5.786392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006261 Headache Nitroglycerin 5.4111554966 11284996
MESH:D034381 Hearing Loss Furosemide 4.9517868369
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006333 Heart Failure Furosemide 7.5916011733 12660669 16845234
MESH:D006333 Heart Failure pirinixic acid 7.5920558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.5216366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly pirinixic acid 8.8519772884 19176532 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8512621046 16120746 15340226
MESH:D006689 Hodgkin Disease marker/mechanism 12453859 16879607
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 15340226 8697196 18606429 16354765
MESH:D006934 Hypercalcemia Furosemide 5.2117652376
MESH:D053565 Hypercalciuria Furosemide 5.8517652376
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D020138 Hyperhomocysteinemia Catechin 5.1017292331
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5917050553
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 6.0915086907
MESH:D006973 Hypertension Arsenic 5.3916076760 11953799 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3918670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.4616612254
MESH:D006987 Hypesthesia Arsenic 5.7816093927
MESH:C537153 Hypomagnesemia primary Furosemide 5.8511041285
MESH:D007019 Hypoproteinemia Furosemide 6.0916096441
MESH:D007022 Hypotension Furosemide 10.3711041285
MESH:D007022 Hypotension Isoflurane 10.3712967683
MESH:D007024 Hypotension, Orthostatic Furosemide 5.6315811171
MESH:D007249 Inflammation Lipopolysaccharides 5.3017237260 9205823 17963957 12878042 17255318
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3012878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.7817255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007642 Keratosis Arsenic 5.1812749816 16930632
MESH:D007674 Kidney Diseases Furosemide 3.8511041285
MESH:D007938 Leukemia arsenic trioxide 2.8915070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 19850784 17050201 16968895 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.0817339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.0812712474 16112521 19075265 12018890 17649720 19035177 17712046 16330433 19642359 16331271 17869043 15748426 15213294 15336539 16891316 17217047 9834237 11468182 12679006 17107899 11161223 15622746 16966277 19225113 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D007970 Leukopenia Lipopolysaccharides 4.8915821434
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.5312878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008107 Liver Diseases Arsenic 2.5711134558
MESH:D008113 Liver Neoplasms Arsenic 11.1016368122
MESH:D008113 Liver Neoplasms arsenic trioxide 11.1014682389
MESH:D008113 Liver Neoplasms pirinixic acid 11.1015890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1016984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.0820377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D055370 Lung Injury Lipopolysaccharides 4.1821114838
MESH:D008175 Lung Neoplasms Arsenic 3.5217306315 19168569 17976673
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5211798837 19825857
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5219555203 11884234
MESH:D008708 Methemoglobinemia Nitroglycerin 4.883537620
MESH:D020326 Migraine without Aura Nitroglycerin 5.2914659530
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2019417148 11468182 15949261 19549372 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2216882451 16105982
MESH:D009203 Myocardial Infarction Nitroglycerin 6.1914729435
MESH:D009203 Myocardial Infarction pirinixic acid 6.1919151258
MESH:D017202 Myocardial Ischemia Arsenic 9.3815371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.3812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009397 Nephrocalcinosis Furosemide 6.0915086907
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects Arsenic 7.7416620997
MESH:D009436 Neural Tube Defects arsenic trioxide 7.7410525206
MESH:D020078 Neurogenic Inflammation Arsenic 4.5217056641
MESH:D053206 Nocturnal Enuresis Furosemide 6.0917945291
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010051 Ovarian Neoplasms Arsenic 5.1517306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1516624393 12452020 19769630
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5715580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1815371236 16905509 6392382
MESH:D010538 Peritonitis Isoflurane 5.4017414419
MESH:D011014 Pneumonia Lipopolysaccharides 4.7512224865 11605937
MESH:D011141 Polyuria Furosemide 5.8517945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11399792 11222880 11896295
MESH:D011471 Prostatic Neoplasms Arsenic 3.3816140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3819131511
MESH:D011507 Proteinuria Arsenic 4.1521343184
MESH:D015427 Reperfusion Injury Furosemide 7.0216526316
MESH:D015427 Reperfusion Injury pirinixic acid 7.0219058328
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.7615912074 16096441 12394941
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8210835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D018805 Sepsis Isoflurane 5.1117414419
MESH:D012871 Skin Diseases Arsenic 2.7817938729 15952646 6392382 17548696 16353154 18709164 19834688 17453740 17050553 16702368 16759981
MESH:D012878 Skin Neoplasms Arsenic 5.9119538983 16251483 15504454 17029826 17976673 17050553
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9116192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.8817007042
MESH:D013274 Stomach Neoplasms Furosemide 2.8817052386
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3015821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.4417976673 19322015 15987713 11144890 18640142 19429237 17306315
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.4411780464 12845720 20435036 12973940
MESH:D014652 Vascular Diseases Arsenic 4.9317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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