AutismKB 2.0

Annotation Detail for TNFSF8


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Basic Information Top
Gene Symbol:TNFSF8 ( CD153,CD30L,CD30LG,MGC138144 )
Gene Full Name: tumor necrosis factor (ligand) superfamily, member 8
Band: 9q32-q33.1
Quick LinksEntrez ID:944; OMIM: 603875; Uniprot ID:TNFL8_HUMAN; ENSEMBL ID: ENSG00000106952; HGNC ID: 11938
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04060Cytokine-cytokine receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1930Graves' disease
2091Hypertension
2051Leukemia
2220Dermatitis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of TNFSF8 mRNAaffects expression 18648102
D001151 Arsenic [Arsenic co-treated with Fluorides] results in decreased expression of TNFSF8 mRNAaffects cotreatment|decreases expression 19962721
D001151 Arsenic Arsenic results in decreased expression of TNFSF8 mRNAdecreases expression 19962721
C006632 arsenic trioxide arsenic trioxide results in increased expression of TNFSF8 mRNAincreases expression 17530438
15761015
D001280 Atrazine Atrazine results in increased expression of TNFSF8 mRNAincreases expression 18585445
D005459 Fluorides [Arsenic co-treated with Fluorides] results in decreased expression of TNFSF8 mRNAaffects cotreatment|decreases expression 19962721
D005459 Fluorides Fluorides results in decreased expression of TNFSF8 mRNAdecreases expression 19962721
D005665 Furosemide Furosemide affects the expression of TNFSF8 mRNAaffects expression 17497460
D017313 Fenretinide Fenretinide results in decreased expression of TNFSF8 mRNAdecreases expression 16467112
C058346 N-(4-methoxyphenyl)retinamide N-(4-methoxyphenyl)retinamide results in decreased expression of TNFSF8 mRNAdecreases expression 16467112
C006253 pirinixic acid pirinixic acid results in decreased expression of TNFSF8 mRNAdecreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of TNFSF8 mRNA]decreases expression|increases reaction 17950772
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TNFSF8 mRNAincreases expression 15310856
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.8911798837 19825857
MESH:D000230 Adenocarcinoma Fenretinide 4.8910697514
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.843712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4817306315
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.4611874814
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D020261 Arsenic Poisoning Arsenic 2.9116251483 18414634 16835338 12569548
MESH:D050197 Atherosclerosis Arsenic 3.3419371607 12928151
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.3116206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001932 Brain Neoplasms Fenretinide 4.5116187019
MESH:D001943 Breast Neoplasms Fenretinide 2.2916601279
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6817687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.853581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.8516507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8516217749 11135700 15553829 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 6.8516270382 17159502
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 5.2718922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 5.2716274795
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2418640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 3.5615738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.4616973168 18022660
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.877505956
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.7116154183
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.2719486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.2719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1612621046 15668235 8697196 15340226 16354765
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.8320501625
MESH:D015179 Colorectal Neoplasms Fenretinide 2.8317273769
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5120055451 15322242 10048152
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.012524372 18759878 8156756 14531868 12868966 11906362 8970840 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.849022650 9328219 8291058 7440962 9653073 18289764 18648102 16192314 18692083 1440618 11289319 6679447 6482804
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004417 Dyspnea Furosemide 5.2116935035
MESH:D004487 Edema Furosemide 12.5411834646
MESH:D004487 Edema pirinixic acid 12.5412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.5411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.603581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6012903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver arsenic trioxide 8.3015073043
MESH:D005234 Fatty Liver pirinixic acid 8.3020131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005534 Foot Diseases Arsenic 5.826392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005909 Glioblastoma Fenretinide 4.0016187019
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D034381 Hearing Loss Furosemide 4.9817868369
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006333 Heart Failure Furosemide 7.6516011733 12660669 16845234
MESH:D006333 Heart Failure pirinixic acid 7.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006529 Hepatomegaly pirinixic acid 8.9918467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.9912621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 18606429 16354765 16959395 15340226
MESH:D006934 Hypercalcemia Furosemide 5.2517652376
MESH:D053565 Hypercalciuria Furosemide 5.8917652376
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6217050553
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 6.1415086907
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Arsenic 5.4211953799 16076760 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4218670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.5016612254
MESH:D006987 Hypesthesia Arsenic 5.8216093927
MESH:C537153 Hypomagnesemia primary Furosemide 5.8911041285
MESH:D007019 Hypoproteinemia Furosemide 6.1416096441
MESH:D007022 Hypotension Furosemide 4.8011041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.6815811171
MESH:D007248 Infertility, Male Atrazine 3.8212948887
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007642 Keratosis Arsenic 5.2312749816 16930632
MESH:D007674 Kidney Diseases Furosemide 3.8611041285
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.116582329
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1620471514 16968895 17050201 16467208 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.1417339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.1415213294 17712046 19225113 16112521 16331271 12712474 17217047 9834237 16966277 16330433 16823087 11468182 15748426 17107899 19075265 19642359 15622746 19035177 16891316 17649720 15336539 11161223 12018890 12679006 17869043
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D007972 Leukoplakia, Oral Fenretinide 6.3116707609
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1812878042
MESH:D008107 Liver Diseases Arsenic 2.5711134558
MESH:D008113 Liver Neoplasms Arsenic 11.1816368122
MESH:D008113 Liver Neoplasms arsenic trioxide 11.1814682389
MESH:D008113 Liver Neoplasms pirinixic acid 11.1815890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.406587162 598648 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.4020377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008175 Lung Neoplasms Arsenic 3.5419168569 17306315 17976673
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5419825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 3.6710697514
MESH:D008545 Melanoma Fenretinide 2.8516270382
MESH:D008654 Mesothelioma Atrazine 3.591916698
MESH:D009062 Mouth Neoplasms Fenretinide 4.4516274795
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2214977855 19549372 15949261 11468182 19417148
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Arsenic 9.4715371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.4712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms Fenretinide 5.4915958647 17353921
MESH:D009369 Neoplasms pirinixic acid 5.4917405874
MESH:D009397 Nephrocalcinosis Furosemide 6.1415086907
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.816679447
MESH:D009436 Neural Tube Defects Arsenic 12.8116620997
MESH:D009436 Neural Tube Defects arsenic trioxide 12.8110525206
MESH:D020078 Neurogenic Inflammation Arsenic 4.5617056641
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.9216303764
MESH:D053206 Nocturnal Enuresis Furosemide 6.1417945291
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.584026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010051 Ovarian Neoplasms Arsenic 8.3417306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.3416624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Fenretinide 8.3416133793
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.7915580305
MESH:D010190 Pancreatic Neoplasms Fenretinide 5.7915580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010300 Parkinson Disease Atrazine 3.3317218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3816093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.236392382 16905509 15371236
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D011141 Polyuria Furosemide 5.8917945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Arsenic 2.7116140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7119131511
MESH:D011471 Prostatic Neoplasms Fenretinide 2.7117024972
MESH:D011507 Proteinuria Arsenic 4.1921343184
MESH:D015427 Reperfusion Injury Furosemide 7.0616526316
MESH:D015427 Reperfusion Injury pirinixic acid 7.0619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.8012394941 16096441 15912074
MESH:D012135 Respiratory Sounds Atrazine 4.7311874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 9.533692021
MESH:D012162 Retinal Degeneration Fenretinide 9.5316303925
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012871 Skin Diseases Arsenic 2.7817938729 16353154 17453740 16702368 17548696 16759981 17050553 6392382 15952646 18709164 19834688
MESH:D012878 Skin Neoplasms Arsenic 14.3215504454 17029826 19538983 16251483 17976673 17050553
MESH:D012878 Skin Neoplasms Fenretinide 14.3216467112
MESH:D012878 Skin Neoplasms N-(4-methoxyphenyl)retinamide 14.3216467112
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.3216192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.8817007042
MESH:D013274 Stomach Neoplasms Furosemide 2.8817052386
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.593712494 1399818 7505956 6587162 6582329
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.5919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.508074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 12.5019429237 17306315 17976673 11144890 18640142 19322015 15987713
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.5011780464 12845720 20435036 12973940
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 12.5016720286
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 4.7216154183
MESH:D014652 Vascular Diseases Arsenic 4.9717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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