AutismKB 2.0

Annotation Detail for GGPS1


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Basic Information Top
Gene Symbol:GGPS1 ( GGPPS,GGPPS1 )
Gene Full Name: geranylgeranyl diphosphate synthase 1
Band: 1q42.3
Quick LinksEntrez ID:9453; OMIM: 606982; Uniprot ID:GGPPS_HUMAN; ENSEMBL ID: ENSG00000152904; HGNC ID: 4249
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5120geranylgeranyldiphosphate biosynthesis
PWY-5910superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
PWY66-5superpathway of cholesterol biosynthesis
PWY-5123trans,trans-farnesyl diphosphate biosynthesis
Pathway IDPathway Name
hsa00900Terpenoid backbone biosynthesis
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
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No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GGPS1 mRNAaffects expression 21346803
D000081 Acetamides Acetamides analog results in decreased activity of GGPS1 proteindecreases activity 16787319
D000082 Acetaminophen Acetaminophen affects the expression of GGPS1 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of GGPS1 mRNAincreases expression 17879257
C518651 digeranyl bisphosphonate digeranyl bisphosphonate results in decreased activity of GGPS1 proteindecreases activity 17208200
C002963 geranylgeranyl pyrophosphate geranylgeranyl pyrophosphate analog results in decreased activity of GGPS1 proteindecreases activity 16787319
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GGPS1 mRNAaffects binding|decreases expression|increases activity 19710929
D012643 Selenium Selenium results in decreased expression of GGPS1 mRNAdecreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of GGPS1 mRNAincreases expression 18175754
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of GGPS1 mRNAincreases expression 18087596
D014810 Vitamin E Vitamin E results in decreased expression of GGPS1 mRNAdecreases expression 19244175
C088658 zoledronic acid zoledronic acid results in decreased activity of GGPS1 proteindecreases activity 17208200
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury zoledronic acid 4.5719715164
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.6420200999
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120464547 20127859
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.7015814487
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.2019898480
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001859 Bone Neoplasms zoledronic acid 5.0716778634 17312309 19442620 16121404 15867366 11697798
MESH:D001862 Bone Resorption zoledronic acid 4.8118404659 16769263 15845617 18496637 11869084 8053405
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4717474063 20146248
MESH:D001943 Breast Neoplasms zoledronic acid 2.4716096432 18695136
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.8616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.863084413
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 6.2511212258
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 6.2519233551
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 3.9018507039
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.0020419170
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 5.0011212258
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.846135515
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D003092 Colitis Selenium 3.9217936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1618551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8716285004
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2411421492 16781746 19085960 19416960 15968718 11461765 12705907 14725611 10915739 19739265 12958197 12392966 16177239 19923254 11287661 19420014 17522070 12540782 14986274 14550746 16081117 12153990 17906064 10774834 18071297 15619225 16109766 2444490 17562736 10663392 18713872 11743745 11529661 19370779 11834606 16485898 11739529 16393943 19164858 16227642 12594235
MESH:D056486 Drug-Induced Liver Injury Selenium 9.2415131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.2415131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005234 Fatty Liver pirinixic acid 2.8720131406 19236843
MESH:D005264 Femoral Fractures zoledronic acid 5.9816234978
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8720471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.8716080930
MESH:D006333 Heart Failure pirinixic acid 7.1720558911
MESH:D006333 Heart Failure Selenium 7.1717162251
MESH:D006529 Hepatomegaly pirinixic acid 3.1316221962 19772884 18467677 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D006930 Hyperalgesia Acetaminophen 8.3016870215
MESH:D006930 Hyperalgesia zoledronic acid 8.3016769263
MESH:D006934 Hypercalcemia zoledronic acid 5.1619622757 18089816
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006996 Hypocalcemia zoledronic acid 6.3712669777
MESH:D007249 Inflammation Tobacco Smoke Pollution 3.3918590791
MESH:D007251 Influenza, Human Selenium 11.5516624496
MESH:D007251 Influenza, Human Vitamin E 11.5516624496
MESH:D007333 Insulin Resistance pirinixic acid 7.5416306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.5414714311
MESH:D007674 Kidney Diseases Acetaminophen 6.1715629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.1712488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0716705839
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.8818089816
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4116169303
MESH:D008107 Liver Diseases Acetaminophen 1.6512969438 16610002 19784758 11587558 19014921 16611625 12587719 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.597678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.5920195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 7.5915890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.616135515 2876784 2876786
MESH:D008171 Lung Diseases Vitamin E 3.2516863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6220064080 20464547 17053015 18569708 6695378 18816296 20869020 20135361 18520028
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 3.6212111688 11091918 3440675 16288123
MESH:D008175 Lung Neoplasms Vitamin E 3.6211062179
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.6815318939
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 6.6817312309
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008654 Mesothelioma Selenium 6.6715107826
MESH:D008654 Mesothelioma zoledronic acid 6.6716675582
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.0816381670
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 9.0815006635
MESH:D009101 Multiple Myeloma zoledronic acid 4.1516996129 18089719 19621390
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0118551238 7678174
MESH:D009362 Neoplasm Metastasis zoledronic acid 3.6819139120 15867366 17312309
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5316049721
MESH:D010014 Osteolysis zoledronic acid 5.5215867366
MESH:D010024 Osteoporosis zoledronic acid 4.1017882678
MESH:D010146 Pain Acetaminophen 7.2716870215
MESH:D010146 Pain zoledronic acid 7.2716475674
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1117292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.1118760546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1115084515
MESH:D011471 Prostatic Neoplasms zoledronic acid 2.1119103299 12438248
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.7618410779
MESH:D012512 Sarcoma, Ewing's zoledronic acid 5.0616121404
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6118551238
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.1819755658 10029692
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 6.1818590791
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.6416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6417053015
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 8.6412846360
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00900 Terpenoid backbone biosynthesis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00399 antagonist Zoledronate Antihypocalcemic Agents;Bisphosphonates;Antiresorptives;Bone Density Conservation Agents
DB02552 - Geranyl Diphosphate
DB04695 - FARNESYL THIOPYROPHOSPHATE
DB04714 - ISOPENTENYL PYROPHOSPHATE
DB06830 - (1-HYDROXYHEPTANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
DB06931 - (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
DB07221 - (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM
DB07410 - [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID
DB07780 - FARNESYL DIPHOSPHATE
DB07841 - GERANYLGERANYL DIPHOSPHATE
DB07873 - (1-HYDROXYDODECANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
DB08529 - (6E,11E)-HEPTADECA-6,11-DIENE-9,9-DIYLBIS(PHOSPHONIC ACID)
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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