AutismKB 2.0

Annotation Detail for IL27RA


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Basic Information Top
Gene Symbol:IL27RA ( CRL1,IL27R,TCCR,WSX1,zcytor1 )
Gene Full Name: interleukin 27 receptor, alpha
Band: 19p13.12
Quick LinksEntrez ID:9466; OMIM: 605350; Uniprot ID:I27RA_HUMAN; ENSEMBL ID: ENSG00000104998; HGNC ID: 17290
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200023IL27-mediated signaling events
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000111 Acetylcysteine Acetylcysteine results in decreased expression of IL27RA mRNAdecreases expression 16084531
C006632 arsenic trioxide arsenic trioxide results in decreased expression of IL27RA mRNAdecreases expression 19128835
D016264 Dextran Sulfate IL27RA protein results in decreased susceptibility to Dextran Sulfatedecreases response to substance 16306766
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of IL27RA mRNAaffects cotreatment|increases expression 15784690
C045651 epigallocatechin gallate epigallocatechin gallate results in decreased expression of IL27RA mRNAdecreases expression 16084531
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IL27RA mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of IL27RA mRNAincreases expression 19619570
D005472 Fluorouracil IL27RA protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D007529 Isoflavones Isoflavones affects the expression of IL27RA mRNAaffects expression 16365062
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IL27RA mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IL27RA mRNAdecreases expression 19619570
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of IL27RA mRNAaffects cotreatment|increases expression 15784690
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 15322242 11752688
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.049612607
MESH:D000230 Adenocarcinoma arsenic trioxide 7.3519825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 7.3511473722
MESH:D000230 Adenocarcinoma Fluorouracil 7.3517638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000505 Alopecia Isoflavones 4.8517569567
MESH:D000740 Anemia Fluorouracil 9.2316511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.2311748828
MESH:D001249 Asthma epigallocatechin gallate 3.4316516891
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 5.2819761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.5416206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Estradiol 1.8512948864 16675129 17289903 14630087 17018787 19861407 18497071 17261762
MESH:D001943 Breast Neoplasms Fluorouracil 1.8519217205 16595493 15136595 16110121 16557594 18357371 18608205
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8520435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 8.6517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.6516835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7616217749 15073043 14691202 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7616924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7618930000 17045692 17088986 16332177 17971768 16799960
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0918695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 5.2317015178
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 5.2316757204 17066447 16280240 18986760
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Isoflavones 4.2617689850
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 7.4518226522
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.4518566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 8697196 12621046 15340226 16354765
MESH:D003092 Colitis Dextran Sulfate 5.8218023891 12065299 15652231 16375993
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2615001691 17016597 17725105 18772588 16510598 17169374 17018589 17287894 17172411 16340194
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.6520501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.6515148649 17016601 16524972 17594712 20501625 14970324 16331619 16391804 16303861 18448328 17454858 15289873 17695437 17255274 18509181 17094418 17401013 18288408 18383874 18949393 18802399 16282729
MESH:D015179 Colorectal Neoplasms Isoflavones 3.6517116718
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5110048152 15322242 20055451
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.5419747007
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 4.7416988119
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.7417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 4.2511287661
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.2520420201
MESH:D004362 Drug Toxicity Lamivudine 14.6215040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 14.6211462148
MESH:D004362 Drug Toxicity Zidovudine 14.6215040536
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.0911473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7312903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7316481741 15173087 16785472 16337965 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver arsenic trioxide 8.7215073043
MESH:D005234 Fatty Liver Zidovudine 8.7218299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005910 Glioma Fluorouracil 2.9316145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5015102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006402 Hematologic Diseases Zidovudine 4.9012579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006509 Hepatitis B Lamivudine 5.2717703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.2715274664 16476009 12044531 15631357 15309715
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1116120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D015658 HIV Infections Lamivudine 7.3311141242 9296927 17530837 20032539
MESH:D015658 HIV Infections Zidovudine 7.3320032539 17358032 11698656 11363243 11141242
MESH:D019584 Hot Flashes Estradiol 11.3217088409
MESH:D019584 Hot Flashes Isoflavones 11.3214716179 17290160
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3118606429 15340226 16354765 8697196 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Dextran Sulfate 4.7020423518 15339030
MESH:D007333 Insulin Resistance Estradiol 3.0716627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Estradiol 2.6715618244
MESH:D007680 Kidney Neoplasms Estradiol 13.4115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 13.4116985049
MESH:D007680 Kidney Neoplasms Zidovudine 13.4112579204
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 10.4212560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 10.4220370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 19850784 16968895 20471514 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3212712474 16331271 19642359 19225113 17712046 11161223 16823087 17107899 16112521 15622746 11468182 17869043 19035177 16966277 17649720 15748426 9834237 12679006 19075265 12018890 15213294 17217047 16891316 15336539 16330433
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 3.6717481882
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6712878042
MESH:D008113 Liver Neoplasms arsenic trioxide 7.7814682389
MESH:D008113 Liver Neoplasms Fluorouracil 7.7817045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7816984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.1420377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008171 Lung Diseases Acetylcysteine 4.1612815614
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0219825857 11798837
MESH:D008175 Lung Neoplasms Fluorouracil 5.0215246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0219555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 5.0218800350
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6617203775 11807958 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008545 Melanoma epigallocatechin gallate 3.0111746506 17992120
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.1017358032
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7616757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2219417148 19549372 14977855 11468182 15949261
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.7317962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316105982 16882451
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4116810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009362 Neoplasm Metastasis Acetylcysteine 3.6414720322
MESH:D009369 Neoplasms Fluorouracil 2.6818239605 18600527 16928823
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009421 Nervous System Malformations Estradiol 10.1416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1414600291
MESH:D009436 Neural Tube Defects Acetylcysteine 8.0219446573
MESH:D009436 Neural Tube Defects arsenic trioxide 8.0210525206
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D010024 Osteoporosis Isoflavones 4.2016562857
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9819769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 4.9819401270
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5415580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.5416929163 16500647 19003803 15113037
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311222880 11399792 11896295 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1119131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.1116740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1118626508 19082440
MESH:D011471 Prostatic Neoplasms Isoflavones 2.1116365062 17571952 17374662 17219775
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1618722050 16160472 15538739 18286688
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.7112210543
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.779296927
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5717007042
MESH:D013274 Stomach Neoplasms Fluorouracil 3.5718567086 17522103 19084572 18396642 16951190 16424979 15786421 17172411 19015929 17498489
MESH:D013274 Stomach Neoplasms Zidovudine 3.5717696246
MESH:D013276 Stomach Ulcer Acetylcysteine 4.1617918041
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2219014326
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5312845720 20435036 12973940 11780464
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
MESH:D014625 Vaginal Neoplasms Zidovudine 4.9712579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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