AutismKB 2.0

Annotation Detail for SH3BP5


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Basic Information Top
Gene Symbol:SH3BP5 ( SAB )
Gene Full Name: SH3-domain binding protein 5 (BTK-associated)
Band: 3p25.1
Quick LinksEntrez ID:9467; OMIM: 605612; Uniprot ID:3BP5_HUMAN; ENSEMBL ID: ENSG00000131370; HGNC ID: 10827
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200005BCR signaling pathway
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Related Diseases/Disorders Top
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Desease Name
CHEMDEPENDENCY
alcohol dependence
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SH3BP5 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SH3BP5 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of SH3BP5 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SH3BP5 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SH3BP5 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SH3BP5 mRNAdecreases expression 20018196
D016572 Cyclosporine Cyclosporine results in increased expression of SH3BP5 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of SH3BP5 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SH3BP5 mRNAaffects cotreatment|increases expression 17942748
C008493 methylselenic acid methylselenic acid affects the expression of SH3BP5 mRNAaffects expression 14617803
D016685 Mitomycin SH3BP5 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D018038 Sodium Selenite Sodium Selenite results in increased expression of SH3BP5 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SH3BP5 mRNAaffects cotreatment|increases expression 17942748
D014635 Valproic Acid Valproic Acid results in increased expression of SH3BP5 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5914514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.598875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9819490988
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D000230 Adenocarcinoma Estradiol 4.2611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.783712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000550 Amblyopia Valproic Acid 5.3317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6217497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8519232924 18940202 19460635 18558336 18396377 20603192 17157402 16609825 17507914 18985861 17688650 15238991 18316065 18775368 18177632
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.121440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.1017594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.1315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.138888407
MESH:D001943 Breast Neoplasms Estradiol 1.9312948864 18497071 17289903 17018787 16675129 17261762 19861407 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.9516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.957296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.953084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.9521507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.9516924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.707296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.327505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.3220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.3212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.3218566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.629022650 19486331
MESH:D002779 Cholestasis Cyclosporine 13.6219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.6217110522 17681005 17333356 16105132 15861022 16919318 11677210
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8215894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.128697196 15668235 16354765 15340226 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.4917688650 16575769 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0918551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8714531868 18759878 2524372 8156756 12868966 11298694 8970840 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.552952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8216285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.4821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.4818692083 16192314 8291058 9328219 9653073 6679447 18289764 1440618 18648102 7440962 11289319 9022650 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.4812958197 18713872 14725611 15968718 19416960 11743745 11287661 19420014 11834606 19370779 10915739 16485898 18071297 11739529 10663392 12392966 12705907 12594235 16227642 14986274 12153990 16393943 11461765 19085960 17522070 10774834 16781746 16081117 19739265 14550746 17906064 16177239 11421492 11529661 15619225 19164858 17562736 2444490 19923254 16109766 12540782
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 15.4815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.4820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 15.481733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004421 Dystonia Valproic Acid 4.111851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.0118566989 11473722 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.2317275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.013922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.637562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.377750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.153659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.433581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4320426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Cyclosporine 13.4019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.4015345470
MESH:D005234 Fatty Liver Valproic Acid 13.4019224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.9816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.198888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D005355 Fibrosis Cyclosporine 8.7212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7220067830
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3611294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9612621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 3.8517088409
MESH:D006849 Hydrocephalus Valproic Acid 4.9517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1415340226 16354765 16959395 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8812200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.5516627594 16393666
MESH:D007333 Insulin Resistance Sodium Selenite 7.5514714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 10.1512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.158314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 10.1515618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.1316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.136582329
MESH:D007680 Kidney Neoplasms Cyclosporine 18.1312371664
MESH:D007680 Kidney Neoplasms Estradiol 18.1315610895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1616294345 17596541
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.239327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.2714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2712878042
MESH:D008107 Liver Diseases Acetaminophen 1.6419460945 16610002 11587558 12969438 19784758 16611625 19014921 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2916871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.662125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Mitomycin 7.6615113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.993712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.998603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9912151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3617228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.3114755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3111884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1214737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5911408345 16891317 17203775 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2318803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.088888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1817596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3216810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9418551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.493581430
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.6811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6814600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.376679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.3716359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.0512819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.056482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010051 Ovarian Neoplasms Estradiol 2.2319401270
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Mitomycin 3.4715113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7411896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.7420603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.6516740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.6516205645
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6518760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.6411422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2319155313
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 6.0618551238
MESH:D012640 Seizures Valproic Acid 6.0614763951 15475178 16876388 11738929 3137016 1511512 11044598 17978042
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6412833885
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.927505956 6582329 1399818 3712494 6587162
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.3317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.603119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.0716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.078074119
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.718888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4010091137
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35735
    • No data
    Releated disease ID Related disease Name
    PA446847Arrhythmogenic Right Ventricular Dysplasia
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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