AutismKB 2.0

Annotation Detail for CD34


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Basic Information Top
Gene Symbol:CD34 ( - )
Gene Full Name: CD34 molecule
Band: 1q32.2
Quick LinksEntrez ID:947; OMIM: 142230; Uniprot ID:CD34_HUMAN; ENSEMBL ID: ENSG00000174059; HGNC ID: 1662
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200130C-MYB transcription factor network
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1725Severe acute respiratory syndrome
1809HIV infection
1934Cancer
2044Pre-Eclampsia
No data
Desease Name
Resting heart rate
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CD34 mRNAaffects expression 17562736
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of CD34 mRNAdecreases expression 12558987
D000968 Antimycin A Antimycin A results in decreased expression of CD34 mRNAdecreases expression 19304788
C006632 arsenic trioxide [Tetradecanoylphorbol Acetate co-treated with arsenic trioxide] results in increased expression of CD34 mRNAaffects cotreatment|increases expression 18922899
C006632 arsenic trioxide [Tetradecanoylphorbol Acetate co-treated with arsenic trioxide] results in increased expression of CD34 proteinaffects cotreatment|increases expression 18922899
D001205 Ascorbic Acid [Tretinoin co-treated with Ascorbic Acid] results in decreased expression of CD34 mRNAaffects cotreatment|decreases expression 16443354
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of CD34 mRNAdecreases expression 17490981
D004041 Dietary Fats Dietary Fats results in increased expression of CD34 mRNAincreases expression 18042831
D017313 Fenretinide Fenretinide results in decreased expression of CD34 mRNAdecreases expression 15958647
C091888 monoisoamyl-2,3-dimercaptosuccinate monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of CD34 mRNA]decreases expression|decreases reaction 19615344
C041786 palm oil palm oil results in increased expression of CD34 mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CD34 mRNAaffects binding|decreases expression|increases activity 19710929
D012402 Rotenone Rotenone results in decreased expression of CD34 mRNAdecreases expression 19304788
C079198 S 1 (combination) S 1 (combination) results in decreased expression of CD34 mRNAdecreases expression 18607998
C017947 sodium arsenite monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of CD34 mRNA]decreases expression|decreases reaction 19615344
C017947 sodium arsenite sodium arsenite results in decreased expression of CD34 mRNAdecreases expression 19615344
D013755 Tetradecanoylphorbol Acetate [Tetradecanoylphorbol Acetate co-treated with arsenic trioxide] results in increased expression of CD34 mRNAaffects cotreatment|increases expression 18922899
D013755 Tetradecanoylphorbol Acetate [Tetradecanoylphorbol Acetate co-treated with arsenic trioxide] results in increased expression of CD34 proteinaffects cotreatment|increases expression 18922899
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of CD34 proteinincreases expression 18922899
D014212 Tretinoin [Tretinoin co-treated with Ascorbic Acid] results in decreased expression of CD34 mRNAaffects cotreatment|decreases expression 16443354
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.7711798837 19825857
MESH:D000230 Adenocarcinoma Fenretinide 4.7710697514
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5016434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9317306315 16712894
MESH:D000505 Alopecia Tretinoin 3.6215955085
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001161 Arteriosclerosis Dietary Fats 3.9015238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.0816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.4116935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.3916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.3919483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.3916206674 16197459
MESH:D001932 Brain Neoplasms Fenretinide 4.3516187019
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.0516443354
MESH:D001943 Breast Neoplasms Dietary Fats 2.0520435547
MESH:D001943 Breast Neoplasms Fenretinide 2.0516601279
MESH:D001943 Breast Neoplasms Tretinoin 2.0516873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6116813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3411589617
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1916168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.893084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.8914691202 16217749 15073043 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 8.8917159502 16270382
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.8917306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.891917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 4.0718212800 18347146
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1212490120
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 14.4116274795
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 14.4115984520
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 14.4118572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 14.4118922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.4116051514 16096774
MESH:D002386 Cataract Acetaminophen 7.2310977129
MESH:D002386 Cataract Tretinoin 7.2317460283
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 2.9919524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 13.0416154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 13.0416129372
MESH:D002779 Cholestasis pirinixic acid 2.8319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1916461808
MESH:D002972 Cleft Palate Tretinoin 2.679407595
MESH:D003092 Colitis Tretinoin 3.7217035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.8020501625
MESH:D015179 Colorectal Neoplasms Fenretinide 2.8017273769
MESH:D003139 Common Cold Ascorbic Acid 5.5117323712
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.6810525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.689125849 8800419 9211117 16925845 14991402 17551590 9664655 10589399 9224671 9142499
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1015213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 3.1016506275
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.5916081117 11529661 16109766 14550746 12958197 17906064 10774834 11739529 16485898 12540782 12392966 19923254 16393943 10915739 19370779 12594235 16177239 11743745 19085960 2444490 17562736 12153990 11834606 19739265 14725611 19164858 16227642 15619225 16781746 18713872 18071297 11287661 11461765 10663392 19416960 19420014 14986274 15968718 17522070 11421492 12705907
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D050171 Dyslipidemias Dietary Fats 3.4518367378
MESH:C538011 Eales disease Ascorbic Acid 5.519068938
MESH:D004487 Edema pirinixic acid 7.0112083418
MESH:D004487 Edema Tetradecanoylphorbol Acetate 7.0111698051 15177302 16716910 7812673 9599246 8273558 8113982
MESH:D004489 Edema, Cardiac Tretinoin 4.5018230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1116569247
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3112903497
MESH:D005124 Eye Abnormalities Tretinoin 3.5816938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 13.1515073043
MESH:D005234 Fatty Liver Dietary Fats 13.1517967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver pirinixic acid 13.1519236843 20131406
MESH:D005355 Fibrosis Dietary Fats 8.8818296743
MESH:D005355 Fibrosis Tretinoin 8.8817994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 11.8216904648
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 11.8219093184
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7016452187
MESH:D005909 Glioblastoma Fenretinide 7.4516187019
MESH:D005909 Glioblastoma Tretinoin 7.4517312396
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 8.3015984520 18607998
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.3016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1916084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 7.0716080930
MESH:D006330 Heart Defects, Congenital Tretinoin 7.079664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006529 Hepatomegaly pirinixic acid 3.0119176532 19772884 16221962 18467677
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.4716490937 16863852
MESH:D006689 Hodgkin Disease sodium arsenite 3.1612676792
MESH:D006930 Hyperalgesia Acetaminophen 7.6316870215
MESH:D006930 Hyperalgesia Tretinoin 7.6316870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6021332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6221332399
MESH:D007248 Infertility, Male sodium arsenite 2.9915346721 12646999
MESH:D007249 Inflammation Dietary Fats 5.3720412841
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 5.377562506 7812673 11698051 8273558 15177302
MESH:D007333 Insulin Resistance Dietary Fats 7.2511836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.2516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7817994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9015992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 5.9715629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 5.9720008137
MESH:D007938 Leukemia arsenic trioxide 6.3415070760
MESH:D007938 Leukemia Tretinoin 6.3417143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.4919077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.4916932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8816968895 16467208 20471514 17050201 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8819850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.6412712474 15213294 17712046 15622746 17649720 19225113 17107899 12018890 19642359 11161223 19075265 16891316 19035177 16966277 9834237 12679006 16112521 16823087 11468182 17217047 16331271 17869043 15748426 16330433 15336539
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.6419075265 19035177 17506722 9834237 15748426 16140955 16788101 17217047 16331271 17361223 17368321 17294898 16935935 16823087 16766008 17107899 19225113 17339181 12679006 17712046 17301526 17649720 19029980 19642359 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3616882451
MESH:D007972 Leukoplakia, Oral Fenretinide 6.0716707609
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.319224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8818296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3415474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3418397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6319014921 16611625 12969438 11587558 19460945 19784758 12587719 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2416871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 7.4414682389
MESH:D008113 Liver Neoplasms pirinixic acid 7.4420007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 7.4415276417 16712894
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.3320377131
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 6.3318544905
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3515213294
MESH:D008171 Lung Diseases Ascorbic Acid 7.7316863852
MESH:D008171 Lung Diseases sodium arsenite 7.7319095001
MESH:D008175 Lung Neoplasms arsenic trioxide 4.9519825857 11798837
MESH:D008175 Lung Neoplasms Ascorbic Acid 4.9516401635
MESH:D008175 Lung Neoplasms sodium arsenite 4.9515276417 17306315 17077188 16712894 19931552
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 4.9511807781
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 6.6210697514
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 6.628985016
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Fenretinide 5.2316270382
MESH:D008545 Melanoma sodium arsenite 5.2316487513 19082730
MESH:D008545 Melanoma Tretinoin 5.2316752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008591 Meningomyelocele Tretinoin 4.4416940565
MESH:D009041 Motion Sickness Dextroamphetamine 5.551613127
MESH:D009062 Mouth Neoplasms Fenretinide 4.3216274795
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1114977855 15949261 19549372 11468182 19417148
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.3916882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.3917596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9716624393
MESH:D009369 Neoplasms Fenretinide 11.9117353921 15958647
MESH:D009369 Neoplasms pirinixic acid 11.9117405874
MESH:D009369 Neoplasms sodium arsenite 11.9111559025
MESH:D009369 Neoplasms Tretinoin 11.9116946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6820056578
MESH:D009410 Nerve Degeneration Rotenone 3.8818619942 17356569 15790535
MESH:D009421 Nervous System Malformations Tretinoin 3.799125849
MESH:D009436 Neural Tube Defects arsenic trioxide 12.1710525206
MESH:D009436 Neural Tube Defects sodium arsenite 12.1712854658
MESH:D009436 Neural Tube Defects Tretinoin 12.179142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.7016303764
MESH:D009765 Obesity Ascorbic Acid 7.4917217161
MESH:D009765 Obesity Dietary Fats 7.4920518802 11836018 17217161 16723640 18674790 18457598 21332399 19632207 20132043
MESH:D009765 Obesity pirinixic acid 7.4920558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.3516624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Fenretinide 11.3516133793
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.3515276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 11.3516936753
MESH:D010146 Pain Acetaminophen 6.5916870215
MESH:D010146 Pain Tretinoin 6.5916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.4215580305
MESH:D010190 Pancreatic Neoplasms Fenretinide 12.4215580305
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 12.4215976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 12.4215976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.3118922899 12065085 18404319 8330346
MESH:D010235 Paraganglioma arsenic trioxide 4.1719927285
MESH:D010300 Parkinson Disease Rotenone 2.9815451049 19232380 18191903 16412576 19114014 16140633 11535288 18619942 11445065
MESH:D020734 Parkinsonian Disorders Rotenone 4.0815574749 18197244 15795934 15927086
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7019131511
MESH:D011471 Prostatic Neoplasms Fenretinide 2.7017024972
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.7016039940
MESH:D011507 Proteinuria Tretinoin 3.6116636307
MESH:D011625 Pterygium Tretinoin 4.8116723453
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.3614606601
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D012162 Retinal Degeneration Fenretinide 4.4016303925
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.3116849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1116283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9716646077
MESH:D012871 Skin Diseases Ascorbic Acid 3.2118709164
MESH:D012878 Skin Neoplasms Fenretinide 13.6816467112
MESH:D012878 Skin Neoplasms sodium arsenite 13.6819524636 18572023
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 13.6811807781 12065085 8985016 18404319 8330346
MESH:D012878 Skin Neoplasms Tretinoin 13.6816467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8012854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5917007042
MESH:D013274 Stomach Neoplasms S 1 (combination) 3.5918506536 16557585 18553229
MESH:D013274 Stomach Neoplasms Tretinoin 3.5917261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 3.9018726076
MESH:D020521 Stroke Ascorbic Acid 4.2916517955 16403987
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.2119014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.2116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9815213294
MESH:D014376 Tuberculosis Tretinoin 3.2316040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.4811780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 8.4816720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.4811723127 16452187 16712894 17306315
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 15.9816154183
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 15.9811813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 15.9816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6416752155
MESH:D014652 Vascular Diseases sodium arsenite 4.4417056641
MESH:D014820 Vitiligo Tretinoin 4.0716761959
MESH:D015430 Weight Gain Dietary Fats 3.7416723640
MESH:D009396 Wilms Tumor Tretinoin 3.9716287080
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:04640 Hematopoietic cell lineage
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26211
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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