AutismKB 2.0

Annotation Detail for AKAP6


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Basic Information Top
Gene Symbol:AKAP6 ( ADAP100,ADAP6,AKAP100,KIAA0311,MGC165020,PRKA6,mAKAP )
Gene Full Name: A kinase (PRKA) anchor protein 6
Band: 14q12
Quick LinksEntrez ID:9472; OMIM: 604691; Uniprot ID:AKAP6_HUMAN; ENSEMBL ID: ENSG00000151320; HGNC ID: 376
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AKAP6 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of AKAP6 mRNAincreases expression 17484886
D003474 Curcumin Curcumin results in increased expression of AKAP6 mRNAincreases expression 18421014
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNA]decreases expression|decreases reaction 18200517
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of AKAP6 mRNA]decreases expression|decreases reaction 11007951
D004041 Dietary Fats Dietary Fats results in increased expression of AKAP6 mRNAincreases expression 18042831
C041786 palm oil palm oil results in increased expression of AKAP6 mRNAincreases expression 18042831
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of AKAP6 mRNA]decreases expression|decreases reaction 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of AKAP6 mRNAdecreases expression 11007951
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNA]decreases expression|decreases reaction 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNAdecreases expression 18200517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.4617887948
MESH:D000544 Alzheimer Disease Curcumin 2.6615590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7816807698
MESH:D050197 Atherosclerosis Curcumin 3.4518704882
MESH:D001327 Autoimmune Diseases Curcumin 4.8019761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D002545 Brain Ischemia Curcumin 4.6716770732
MESH:D001932 Brain Neoplasms Curcumin 4.1617596214
MESH:D001943 Breast Neoplasms Curcumin 1.9019250217 16243823 18462866 18593918
MESH:D001943 Breast Neoplasms Dietary Fats 1.9020435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9020435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.083786805 15673190 16192424 16227642 10355542 15721981 16097048 15700767 16124888 18705752 16011737 16050911
MESH:D002277 Carcinoma Curcumin 8.9318593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.9316835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8518788625
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0418414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8218462866
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 16120746 18850075
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1912621046 8697196 16354765 15340226 15668235
MESH:D003092 Colitis Curcumin 10.9918200517 16804969 16782535
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 10.9918023891 16867261 16804969 17936198 16474422 17991707 16782535 11698051 18200517
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.5117276891
MESH:D003103 Coloboma Curcumin 4.7918809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5319359593 16340194
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 5.2018497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.5718403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5717107852
MESH:D003928 Diabetic Nephropathies Curcumin 4.2218204486
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.923732212 9327722 11566570 10092053 15998439 7179309 6623471 16227642 19085960 10915739 7440962 2869522 16177239 6884620 3786805 21278145 17522070 15027814 7120509 15968718 19336974 4309450
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004381 Duodenal Ulcer Curcumin 4.3317351913
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.6815959796 19224547 17595544 61145 16239168 12631006 16045604 12795759
MESH:D005234 Fatty Liver Curcumin 14.6819297423
MESH:D005234 Fatty Liver Dietary Fats 14.6817967931 19551842 18296743 19004024
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Carbon Tetrachloride 31.4518705752
MESH:D005355 Fibrosis Curcumin 31.4518705752
MESH:D005355 Fibrosis Dietary Fats 31.4518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 31.4520067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 31.4517994277
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.0018462866
MESH:D005909 Glioblastoma Curcumin 3.6217596214
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8118462866 18829502
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2016120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.3517701891
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4218606429 8697196 16959395 16354765 15340226
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006937 Hypercholesterolemia Curcumin 10.0518704882
MESH:D006937 Hypercholesterolemia Dietary Fats 10.0521332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007249 Inflammation Curcumin 9.0218403477 17151092 16956363
MESH:D007249 Inflammation Dietary Fats 9.0220412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.0212200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.9618596194 18200517
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.9618200517
MESH:D007333 Insulin Resistance Dietary Fats 3.2518457598 11836018
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.9117994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.4510783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007889 Leiomyoma Curcumin 4.8318555241
MESH:D007938 Leukemia Curcumin 3.3418462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4516106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.0416106398
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0316221502 11903743 17174718 11408273 16239168 16943688 17334410 21278145 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 7.0318296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6416097048 15818738 15123356 15338365 15893842 18054572 18317297 17761835 17976157 17805973 18263696 12389079 17766677 17698563 18420326 15925388 16033810 14620537 15362042 18006644 20821823 14716496 14724832 15673190 16638106 12666154 15052691 17823541 12632512 14512876 18472094 15370692 15057751 17481882 17900296 18210741 18705752 17708605 17922224 16248980 18277467 16015684 16136751 12632514 15959796 12445418 16116963 15730626 17944888 18251166 18166357 18205269 16192424 12546737 11481614 17714472 18481824 12898905 18187930 18429990 18395095 12445421 18472332 12958196 17565644 18412020 17869086 12741479 12649538 12667390 12609069 17525996 14716833 10355542 15650968 13678700 16011737 18418968 18339082 17721639 14748882 18395914 15931870 17640975 17631135 17557913 16027843 15876570 18376398 18156304 15996030 12586293 18279442
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.6418705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6412878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.4316246199 17285989 15830285 16964402 15720792
MESH:D008107 Liver Diseases Curcumin 4.4316956363
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9214706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6519294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.2312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2312151625
MESH:D008175 Lung Neoplasms Curcumin 2.5019359593 16243823 18462866
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5011884234 19555203
MESH:D008223 Lymphoma Curcumin 3.7518462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.0016173963
MESH:D008545 Melanoma Curcumin 2.4418462866 17885582
MESH:D008569 Memory Disorders Curcumin 4.4317263510
MESH:D009101 Multiple Myeloma Curcumin 3.6819372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.2617962980
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009361 Neoplasm Invasiveness Curcumin 4.6518495463
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.9112497104
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009423 Nervous System Neoplasms Curcumin 6.0118462866
MESH:D009765 Obesity Curcumin 4.9419297423
MESH:D009765 Obesity Dietary Fats 4.9417217161 16723640 21332399 11836018 20518802 18457598 18674790 20132043 19632207
MESH:D010024 Osteoporosis Curcumin 3.6118719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8818462866 19020741
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0017440100 19196508 19401701
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.4617698068
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Curcumin 3.6418156803 18226269 15129424 18769126 10851300 12497104 11398177
MESH:D011656 Pulmonary Emphysema Curcumin 4.7619168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2810666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012509 Sarcoma Curcumin 4.3418462866
MESH:D018805 Sepsis Curcumin 4.2818389075
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013276 Stomach Ulcer Curcumin 3.7319188055 16631530
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D001749 Urinary Bladder Neoplasms Curcumin 2.9618593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.6018462866
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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