AutismKB 2.0

Annotation Detail for NAPSA


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Basic Information Top
Gene Symbol:NAPSA ( KAP,Kdap,NAP1,NAPA,SNAPA )
Gene Full Name: napsin A aspartic peptidase
Band: 19q13.33
Quick LinksEntrez ID:9476; OMIM: 605631; Uniprot ID:NAPSA_HUMAN; ENSEMBL ID: ENSG00000131400; HGNC ID: 13395
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2014Pulmonary alveolar proteinosis
2066Lung cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in decreased expression of NAPSA mRNAdecreases expression 17991464
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NAPSA mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of NAPSA mRNAincreases expression 15003993
14729362
D005419 Flavonoids Flavonoids results in decreased expression of NAPSA mRNAdecreases expression 18035473
C029938 nickel sulfate nickel sulfate results in decreased expression of NAPSA mRNAdecreases expression 16100012
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NAPSA mRNAaffects binding|decreases expression|increases activity 19710929
D011374 Progesterone Progesterone affects the expression of NAPSA mRNAaffects expression 17251523
C025643 vinclozolin vinclozolin affects the expression of NAPSA mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury nickel sulfate 10.0219131640 16100012 11954676 12718980
MESH:D055371 Acute Lung Injury pirinixic acid 10.0218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0318218290 20041841 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 4.0818651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.9019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.9019483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7117868700
MESH:D001930 Brain Injuries Progesterone 4.5615665606 15380490 15845082
MESH:D001943 Breast Neoplasms Progesterone 2.4316175315 15562024 17614352
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9619225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4218974383
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.9716780908 11298694 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003929 Diabetic Neuropathies Progesterone 4.8017187935
MESH:D056486 Drug-Induced Liver Injury Amiodarone 2.4418218290 15265979
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.0617692515
MESH:D004715 Endometriosis Progesterone 3.9916134523
MESH:D005234 Fatty Liver Amiodarone 8.6214986274
MESH:D005234 Fatty Liver pirinixic acid 8.6219236843 20131406
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly Amiodarone 9.6215265979
MESH:D006529 Hepatomegaly pirinixic acid 9.6219176532 16221962 18467677 19772884
MESH:D006937 Hypercholesterolemia Amiodarone 4.128137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D007037 Hypothyroidism Amiodarone 4.8218020914 17991464
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7115869954
MESH:D007248 Infertility, Male vinclozolin 3.1916467254
MESH:D007249 Inflammation Flavonoids 5.6417296493
MESH:D007249 Inflammation Progesterone 5.6415869954
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008064 Lipidoses Amiodarone 3.6815342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.8915890375 16377806 20007298
MESH:D008133 Long QT Syndrome Amiodarone 3.7615350150 17391786 11989578
MESH:D008171 Lung Diseases Amiodarone 3.5312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8518516814
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.0117203775 11408345
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009181 Mycoses Amiodarone 5.2817974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010051 Ovarian Neoplasms Progesterone 2.5817393432 16525653
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2319015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9311597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9218045962
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4218724381
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.798532709
MESH:D013119 Spinal Cord Injuries Progesterone 4.6215862959 16503802
MESH:D013276 Stomach Ulcer Amiodarone 3.5518087811
MESH:D013610 Tachycardia Amiodarone 4.5711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4719225199
MESH:D013959 Thyroid Diseases Amiodarone 5.1319731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.1718020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.5311989578 17467628
Pathway ID Pathway Name
KEGG:04142 Lysosome
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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