AutismKB 2.0

Annotation Detail for MAPK8IP1


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Basic Information Top
Gene Symbol:MAPK8IP1 ( IB1,JIP-1,JIP1,PRKM8IP )
Gene Full Name: mitogen-activated protein kinase 8 interacting protein 1
Band: 11p11.2
Quick LinksEntrez ID:9479; OMIM: 604641; Uniprot ID:JIP1_HUMAN; ENSEMBL ID: ENSG00000121653; HGNC ID: 6882
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1783Testicular tumor
1831Prostate cancer
Desease Name
Alzheimer's disease
NEUROLOGICAL
No data
Desease Name
Diabetes mellitus, noninsulin-dependent
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063261 acetylleucyl-leucyl-norleucinal acetylleucyl-leucyl-norleucinal results in increased expression of MAPK8IP1 proteinincreases expression 15618349
C063261 acetylleucyl-leucyl-norleucinal acetylleucyl-leucyl-norleucinal results in increased expression of MAPK8IP1 proteinincreases expression 15618349
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAPK8IP1 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MAPK8IP1 mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MAPK8IP1 mRNAincreases expression 16644059
D003024 Clozapine Clozapine results in increased expression of MAPK8IP1 mRNAincreases expression 17266109
C067713 lactacystin lactacystin results in increased expression of MAPK8IP1 proteinincreases expression 15618349
C067713 lactacystin lactacystin results in increased expression of MAPK8IP1 proteinincreases expression 15618349
C005219 methyl cellosolve methyl cellosolve results in increased expression of MAPK8IP1 mRNAincreases expression 19643169
C406082 monomethylarsonous acid monomethylarsonous acid results in decreased expression of MAPK8IP1 mRNAdecreases expression 20024957
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of MAPK8IP1 mRNAdecreases expression 17616710
D010622 Phencyclidine Phencyclidine results in increased expression of MAPK8IP1 mRNAincreases expression 17266109
D010656 Phenylephrine MAPK8IP1 protein affects the susceptibility to Phenylephrineaffects response to substance 11513749
D010656 Phenylephrine MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]decreases reaction|increases expression 11513749
D010656 Phenylephrine MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]decreases reaction|increases expression 11513749
D010656 Phenylephrine MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]decreases reaction|increases expression 11513749
D010656 Phenylephrine MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]decreases reaction|increases expression 11513749
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MAPK8IP1 mRNAaffects binding|increases activity|increases expression 19710929
D013755 Tetradecanoylphorbol Acetate MAPK8IP1 protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NPPA mRNA]decreases reaction|increases expression 11513749
C025643 vinclozolin vinclozolin affects the expression of MAPK8IP1 mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of MAPK8IP1 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 4.723652986 6499812 6474471
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6016434500
MESH:D000380 Agranulocytosis Clozapine 5.1614617031 16160616 12649775
MESH:D000748 Anemia, Macrocytic methyl cellosolve 6.483699323
MESH:D001008 Anxiety Disorders vinclozolin 3.7019015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1917460149
MESH:D053627 Asthenozoospermia methyl cellosolve 5.643987992
MESH:D001284 Atrophy methyl cellosolve 5.283699323 2626667 6705890
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2319483382
MESH:D001919 Bradycardia Phenylephrine 4.6615306635
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8818705752 15673190 16050911 16227642 16192424 15700767 10355542 15721981 16011737 16124888 3786805 16097048
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8418788625
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 2.9818922899
MESH:D006332 Cardiomegaly Phenylephrine 3.5715728586 11754973 17124262 16170337 17287366 11179087
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 3.9819716837
MESH:D002764 Cholecystitis methyl cellosolve 5.936499794
MESH:D002779 Cholestasis pirinixic acid 2.8819176532
MESH:D003072 Cognition Disorders Clozapine 5.0717123785
MESH:D000013 Congenital Abnormalities methyl cellosolve 4.8812530607 6499821
MESH:D003456 Cryptorchidism vinclozolin 4.4414966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9916402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.6915331141
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0616227642 3732212 19085960 15998439 16177239 6884620 15968718 7179309 17522070 15027814 4309450 3786805 19336974 6623471 9327722 7120509 11566570 10092053 10915739 2869522 7440962 21278145
MESH:D050171 Dyslipidemias Clozapine 4.2416402076
MESH:D004487 Edema pirinixic acid 7.2612083418
MESH:D004487 Edema Tetradecanoylphorbol Acetate 7.267812673 11698051 8273558 15177302 9599246 16716910 8113982
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7916704527 16805852 15623463 15547733 15547721 16510608 15150132 15878914 15264214
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.9515959796 16239168 12631006 17595544 16045604 61145 19224547 12795759
MESH:D005234 Fatty Liver pirinixic acid 7.9520131406 19236843
MESH:D005327 Fetal Resorption methyl cellosolve 5.686474471 3987992 6499821 6499812
MESH:D020567 Fetal Weight methyl cellosolve 5.936474471 6499812 6499821
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5618705752
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.573652986
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4316417039
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.906499821
MESH:D006461 Hemolysis methyl cellosolve 5.5917874071
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.1018467677 16221962 19772884 19176532
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006948 Hyperkinesis Clozapine 5.0316046005
MESH:D006973 Hypertension Phenylephrine 3.1012717712 8949925
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D006984 Hypertrophy Phenylephrine 4.6312791704 18502941
MESH:D007248 Infertility, Male methyl cellosolve 7.433987992
MESH:D007248 Infertility, Male vinclozolin 7.4316467254
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 3.138273558 7562506 7812673 11698051 15177302
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8516417039
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 4.556499821
MESH:D008064 Lipidoses Clozapine 4.0217567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8521278145 17174718 16943688 16221502 11408273 17157831 17334410 11903743 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3415650968 17823541 15893842 12389079 18429990 18006644 15996030 15931870 17525996 15370692 12958196 16136751 12898905 15925388 14724832 14620537 16027843 17481882 17721639 18395914 12445421 18054572 14716833 16248980 18481824 17976157 13678700 15673190 18418968 14748882 18156304 14716496 10355542 12649538 18166357 17922224 17557913 12666154 16033810 15730626 11481614 14512876 18279442 18472332 20821823 17698563 12741479 17869086 12632514 16011737 15123356 18251166 12586293 16638106 17944888 12445418 17766677 17805973 17640975 18376398 15057751 17761835 18705752 12546737 16097048 18472094 18420326 15338365 15876570 17714472 12667390 15052691 15362042 17708605 18187930 16015684 18339082 18210741 17900296 18277467 18395095 18412020 12609069 15818738 17631135 16116963 12632512 18317297 16192424 18263696 18205269 17565644 15959796
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3415474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1015720792 17285989 15830285 16246199 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7716899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.5319294768
MESH:D008113 Liver Neoplasms pirinixic acid 4.5315890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6615583823 12014681
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 2.4711807781
MESH:D008231 Lymphopenia methyl cellosolve 5.903699323
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.408985016
MESH:D001523 Mental Disorders Clozapine 4.0616856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.4819142101
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009765 Obesity Clozapine 4.7618515891 19142110
MESH:D009765 Obesity pirinixic acid 4.7620558911
MESH:D009845 Oligospermia methyl cellosolve 5.303987992
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.1615976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.4012065085 18404319 8330346 18922899
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 10.537974496 12530607 6499817
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.5318220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0518220299
MESH:D011472 Prostatitis vinclozolin 5.0518629315
MESH:D011618 Psychotic Disorders Clozapine 4.2415331141
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012559 Schizophrenia Clozapine 2.7418855531 19369910 11763009 20521326 20168265 20521320 17726453 16141801 20580759 11151749 20452607 17123785 20107430 18806925 17667964
MESH:D012852 Sinusitis Phenylephrine 4.827327846
MESH:D012871 Skin Diseases monomethylarsonous acid 3.3917431481
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 3.3112065085 18404319 11807781 8330346 8985016
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3217575124 12958204
MESH:D013733 Testicular Diseases methyl cellosolve 5.206499806
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 3.4720375083
MESH:D015430 Weight Gain Clozapine 4.5420107430 20521320 17502770 16402076 16141801 20564506
MESH:D015431 Weight Loss Clozapine 5.1917933447
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01782 - 2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One
DB07218 - 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE
DB07272 - N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE
DB07276 - 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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