Gene Symbol:	PIGB ( MGC21236 )
Gene Full Name:	phosphatidylinositol glycan anchor biosynthesis, class B
Band:	15q21.3
Quick Links	Entrez ID:9488; OMIM: 604122; Uniprot ID:PIGB_HUMAN; ENSEMBL ID: ENSG00000069943; HGNC ID: 8959
Relate to Another Database:	SFARIGene; denovo-db

Pathway ID	Pathway Name
hsa00563	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100	Metabolic pathways

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene affects the expression of PIGB mRNA	affects expression	21346803
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PIGB mRNA	increases expression	17879257
D016572	Cyclosporine	Cyclosporine results in decreased expression of PIGB mRNA	decreases expression	20106945

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000230	Adenocarcinoma	Benzo(a)pyrene	2.06	20464547 20127859
MESH:D000236	Adenoma	Benzo(a)pyrene	2.88	6695378
MESH:D017544	Aortic Aneurysm, Abdominal	Benzo(a)pyrene	4.73	19183758
MESH:D001943	Breast Neoplasms	Benzo(a)pyrene	1.99	17474063 20146248
MESH:D006528	Carcinoma, Hepatocellular	2,6-dinitrotoluene	1.79	16705839
MESH:D002294	Carcinoma, Squamous Cell	Benzo(a)pyrene	2.14	20419170
MESH:D002471	Cell Transformation, Neoplastic	2,6-dinitrotoluene	7.56	6135515
MESH:D002471	Cell Transformation, Neoplastic	Cyclosporine	7.56	12371664
MESH:D002779	Cholestasis	Cyclosporine	3.24	19486331
MESH:D003490	Cyanosis	2,6-dinitrotoluene	4.67	18551238
MESH:D056486	Drug-Induced Liver Injury	2,6-dinitrotoluene	2.06	18551238 21346803
MESH:D004938	Esophageal Neoplasms	Benzo(a)pyrene	2.09	16530937
MESH:D005234	Fatty Liver	Cyclosporine	3.34	19224547
MESH:D005355	Fibrosis	Cyclosporine	3.79	12168785 12639820
MESH:D005885	Gingival Hyperplasia	Cyclosporine	4.96	8708960
MESH:D006330	Heart Defects, Congenital	Benzo(a)pyrene	2.85	20471113
MESH:D006457	Hemoglobinuria, Paroxysmal	Cyclosporine	5.16	15720958
MESH:D006973	Hypertension	Cyclosporine	2.23	10903974
MESH:D007638	Keratoconjunctivitis Sicca	Cyclosporine	5.31	15604871
MESH:D007674	Kidney Diseases	Cyclosporine	2.56	8314463 10903974 18776723
MESH:D007680	Kidney Neoplasms	2,6-dinitrotoluene	8.59	16705839
MESH:D007680	Kidney Neoplasms	Cyclosporine	8.59	12371664
MESH:D008113	Liver Neoplasms	2,6-dinitrotoluene	4.93	7678174
MESH:D008113	Liver Neoplasms	Benzo(a)pyrene	4.93	21137059 20195826
MESH:D008114	Liver Neoplasms, Experimental	2,6-dinitrotoluene	2.79	2876784 2876786 6135515
MESH:D008175	Lung Neoplasms	Benzo(a)pyrene	1.57	20064080 20464547 20135361 18520028 18569708 17053015 6695378 18816296 20869020
MESH:D008664	Metal Metabolism, Inborn Errors	Cyclosporine	5.65	16801185
MESH:D009062	Mouth Neoplasms	Benzo(a)pyrene	3.53	16381670
MESH:D009336	Necrosis	2,6-dinitrotoluene	4.60	18551238 7678174
MESH:D009369	Neoplasms	Benzo(a)pyrene	2.35	11141357
MESH:D009402	Nephrosis, Lipoid	Cyclosporine	5.31	17954296
MESH:D009404	Nephrotic Syndrome	Cyclosporine	3.70	18481113 19348381
MESH:D009784	Occupational Diseases	2,6-dinitrotoluene	3.88	16049721
MESH:D011230	Precancerous Conditions	Cyclosporine	3.64	12371664
MESH:D011471	Prostatic Neoplasms	Benzo(a)pyrene	2.90	17292933
MESH:D011565	Psoriasis	Cyclosporine	2.34	16882103
MESH:D012640	Seizures	2,6-dinitrotoluene	2.82	18551238
MESH:D012878	Skin Neoplasms	Benzo(a)pyrene	2.54	10029692 19755658
MESH:D013274	Stomach Neoplasms	Benzo(a)pyrene	1.56	20155912 2093021
MESH:D001749	Urinary Bladder Neoplasms	2,6-dinitrotoluene	5.44	16049721
MESH:D001749	Urinary Bladder Neoplasms	Benzo(a)pyrene	5.44	17053015
MESH:D014571	Urologic Neoplasms	2,6-dinitrotoluene	5.06	10091137
MESH:D014605	Uveitis	Cyclosporine	4.85	1336536
MESH:D014985	Xerophthalmia	Cyclosporine	5.31	17120751

Pathway ID	Pathway Name
KEGG:00563	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
KEGG:01100	Metabolic pathways
REACT:17015	Metabolism of proteins

AutismKB 2.0

Annotation Detail for PIGB

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