AutismKB 2.0

Annotation Detail for SLC4A8


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Basic Information Top
Gene Symbol:SLC4A8 ( DKFZp761B2318,FLJ46462,NBC3,NDCBE )
Gene Full Name: solute carrier family 4, sodium bicarbonate cotransporter, member 8
Band: 12q13.13
Quick LinksEntrez ID:9498; OMIM: 605024; Uniprot ID:S4A8_HUMAN; ENSEMBL ID: ENSG00000050438; HGNC ID: 11034
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Transmembrane transport of small molecules
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SLC4A8 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SLC4A8 mRNAincreases expression 17879257
D016047 Zalcitabine [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of SLC4A8 mRNAaffects cotreatment|increases expression 18606552
D004958 Estradiol Estradiol results in increased expression of SLC4A8 mRNAincreases expression 17962382
C514793 gp120 protein, Human immunodeficiency virus 1 [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of SLC4A8 mRNAaffects cotreatment|increases expression 18606552
D013629 Tamoxifen Tamoxifen results in increased expression of SLC4A8 mRNAincreases expression 17962382
C025643 vinclozolin vinclozolin affects the expression of SLC4A8 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.4711473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8619015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8517474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 1.8512948864 17261762 16675129 17289903 19861407 14630087 17018787 18497071
MESH:D001943 Breast Neoplasms Tamoxifen 1.8517242785 18984771 16873071 18351453 19189210 18997820 20390343 18629630 21152245 20065188 19200415 15565566 17049068 19155303 19115204 15668708 21138602 16202921 19189212 18821012 19410462 16818667 19487384 20005174 16273361 19103187 18815881 19142967 20859285 19066611 19288272 19244106 19059307 19011961 17261762 20544844 17440819 11161223 17893378 19084267 19221464 18855134 18425577 20135344 19289846
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.723084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7216924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7216924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D009202 Cardiomyopathies Zalcitabine 4.8810591146
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D003456 Cryptorchidism vinclozolin 4.6714966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003928 Diabetic Nephropathies Estradiol 9.6819279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.6819279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6517522070 15619225 11421492 11739529 19416960 17906064 19085960 12153990 11834606 11743745 16485898 12705907 16227642 18713872 11461765 19923254 18071297 11529661 12594235 10915739 12392966 14550746 17562736 11287661 15968718 12540782 19420014 10663392 19164858 2444490 14725611 16393943 16781746 16081117 16177239 16109766 12958197 19739265 19370779 10774834 14986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Zalcitabine 5.057515130
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.8719031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.9618566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.9617893378 16202921 19155303 20544844
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver Tamoxifen 9.3619224547 14986274
MESH:D005234 Fatty Liver Zalcitabine 9.3618299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.3316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.7416417039
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D015658 HIV Infections Zalcitabine 4.4617457083
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D007248 Infertility, Male vinclozolin 3.2116467254
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007333 Insulin Resistance Estradiol 3.1316627594 16393666
MESH:D007674 Kidney Diseases Acetaminophen 6.3712587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.3715618244
MESH:D007680 Kidney Neoplasms Estradiol 8.1815610895
MESH:D007680 Kidney Neoplasms Tamoxifen 8.1818625569
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1316417039
MESH:D008064 Lipidoses Tamoxifen 3.3517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5118564211
MESH:D008107 Liver Diseases Acetaminophen 1.6819784758 12969438 11587558 19014921 16610002 19460945 16611625 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8120195826 21137059
MESH:D008113 Liver Neoplasms Tamoxifen 4.8116684651
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4320135361 18569708 17053015 18816296 6695378 18520028 20869020 20464547 20064080
MESH:D008175 Lung Neoplasms Tamoxifen 2.4318625569
MESH:D008223 Lymphoma Zalcitabine 4.8311980663 8840982 9205081 8764131 17941976 9488045 18798262
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.5316891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5319196722 19196723 14580682 16827153 11731420
MESH:D020149 Manganese Poisoning Estradiol 14.1719453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.1719453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009374 Neoplasms, Experimental Zalcitabine 5.469205081 8764131 9488045
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419196722 19200415 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 3.9811399458 16427766
MESH:D009437 Neuralgia Zalcitabine 6.7117292584
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010523 Peripheral Nervous System Diseases gp120 protein, Human immunodeficiency virus 1 12.0518606552
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 12.0518606552
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2918220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.3318220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4517292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.4516740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4515067354
MESH:D011472 Prostatitis vinclozolin 5.3318629315
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4819755658 10029692
MESH:D013088 Spermatocele Tamoxifen 4.7416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3017053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.3017572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 3.2810982225
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
Drug Bank Top
No data
No data
Drugbank ID Action Drug Name Description
DB01390 substrate Woodward's Gripe Water Antidiarrheals
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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