AutismKB 2.0

Annotation Detail for SCARB2


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Basic Information Top
Gene Symbol:SCARB2 ( AMRF,CD36L2,HLGP85,LIMPII,SR-BII )
Gene Full Name: scavenger receptor class B, member 2
Band: 4q21.1
Quick LinksEntrez ID:950; OMIM: 602257; Uniprot ID:SCRB2_HUMAN; ENSEMBL ID: ENSG00000138760; HGNC ID: 1665
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Action myoclonus-renal failure syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SCARB2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SCARB2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SCARB2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SCARB2 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of SCARB2 mRNAdecreases expression 15336504
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of SCARB2 mRNAincreases expression 15289156
D004958 Estradiol Estradiol affects the expression of SCARB2 mRNAaffects expression 15598610
D004958 Estradiol Estradiol results in increased expression of SCARB2 mRNAincreases expression 15289156
D004997 Ethinyl Estradiol ESR1 protein promotes the reaction [Ethinyl Estradiol results in increased expression of SCARB2 protein modified form]increases expression|increases reaction 17673517
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SCARB2 mRNAaffects expression 16079270
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SCARB2 mRNAincreases expression 17557909
15834898
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of SCARB2 mRNAincreases expression 17317680
D019833 Genistein Genistein results in increased expression of SCARB2 mRNAincreases expression 15289156
D009151 Mustard Gas Mustard Gas results in increased expression of SCARB2 mRNAincreases expression 18988085
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of SCARB2 mRNAincreases expression 17616710
C006253 pirinixic acid pirinixic acid results in increased expression of SCARB2 mRNAincreases expression 17426115
18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Estradiol 7.1811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1814692618
MESH:D000230 Adenocarcinoma Genistein 7.1811473722
MESH:D000236 Adenoma 2-Acetylaminofluorene 3.7910737359
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.146705139
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6016434500
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5715469931
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001249 Asthma Mustard Gas 2.7310378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001768 Blister Mustard Gas 5.2819167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2319483382
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9815324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 1.9814630087 17289903 16675129 12948864 17261762 19861407 18497071 17018787
MESH:D001943 Breast Neoplasms Genistein 1.9817200150 16541309 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1117687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 14.3016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 14.3016705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 14.303084413 10737359 17761372 6705139 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.303084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 14.3016924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.3016924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 14.3016924424
MESH:D002318 Cardiovascular Diseases Genistein 3.3616332659
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.856135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8518566989
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9416105132 15861022 17681005 17110522 16919318 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 7.9419176532
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.6516002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.2518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.2518551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5016647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.3018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3016485898 16227642 15968718 11421492 2444490 10915739 16393943 17522070 19923254 11834606 16109766 19416960 11529661 12705907 12958197 18713872 16177239 10663392 12392966 17906064 14550746 12153990 19370779 14986274 16081117 14725611 12540782 16781746 15619225 11287661 12594235 19739265 11739529 18071297 11743745 11461765 19085960 19164858 17562736 10774834 19420014
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004487 Edema Mustard Gas 7.159260866 11428647 11402378 11428631
MESH:D004487 Edema pirinixic acid 7.1512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 12.2916402032
MESH:D004714 Endometrial Hyperplasia Genistein 12.2916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 12.8215700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 12.8219148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 12.8211473722
OMIM:254900 EPILEPSY, PROGRESSIVE MYOCLONIC 4, WITH OR WITHOUT RENAL FAILURE marker/mechanism
MESH:D004890 Erythema Mustard Gas 5.289357497
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7916510608 16805852 15878914 15547721 15547733 15264214 15150132 16704527 15623463
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.8215345470
MESH:D005234 Fatty Liver pirinixic acid 7.8219236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7016002989 16611131 15751030 16534752 16513791
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.0616452187
MESH:D005909 Glioblastoma Genistein 3.3116598420
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.456705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.496705139
MESH:D006529 Hepatomegaly pirinixic acid 3.1018467677 16221962 19772884 19176532
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.5412960047 14722030
MESH:D007021 Hypospadias Diethylstilbestrol 11.6016002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.6016569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.4515036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Mustard Gas 2.8211428620 11428631 11402378 9357497 9260866 17524151 8975870 11428647 16001271
MESH:D007333 Insulin Resistance Estradiol 7.3716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.3716306350
MESH:D007674 Kidney Diseases Acetaminophen 6.0315629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.0315618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.3616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.3616705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 18.3615003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 18.3615610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.1617184923
MESH:D007938 Leukemia Genistein 3.0618980019 17468513
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5317823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5315474484
MESH:D008107 Liver Diseases Acetaminophen 1.6519460945 12587719 19784758 16611625 16610002 11587558 19014921 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.007678174
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 11.0014678523 11376686 18001218 10737359 16273603 10672840
MESH:D008113 Liver Neoplasms Diethylstilbestrol 11.0015890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 11.0015890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.422876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 6.426150874 1399818 534488
MESH:D008171 Lung Diseases Mustard Gas 3.5018161513 18702808
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 2.9511376686
MESH:D008175 Lung Neoplasms Mustard Gas 2.953148597 8781369
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2715166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5315700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.6516002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.2511408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.2514578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction Genistein 5.7817141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.7819151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 14.5416810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 14.5417141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 14.5416411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.7418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.7418551238 7678174
MESH:D009369 Neoplasms Diethylstilbestrol 5.1615313581
MESH:D009369 Neoplasms pirinixic acid 5.1617405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 17.0611399458
MESH:D009421 Nervous System Malformations Estradiol 17.0616427766 11399458
MESH:D009421 Nervous System Malformations Genistein 17.0616427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009503 Neutropenia Mustard Gas 4.0616761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.1416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.1416049721
MESH:D010024 Osteoporosis Genistein 3.3019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1716169203
MESH:D010051 Ovarian Neoplasms Estradiol 4.9819401270
MESH:D010051 Ovarian Neoplasms Genistein 4.9819005980
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7715687265 16977796
MESH:D011041 Poisoning Mustard Gas 3.8815727166
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.2317184923
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.6115846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.6116740699
MESH:D011471 Prostatic Neoplasms Genistein 2.6116925846 15256057 15378649
MESH:D011537 Pruritus Ethinyl Estradiol 9.9215861022 16919318
MESH:D011537 Pruritus Mustard Gas 9.9218058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9517620002 17266442 17720292 10334151 17894541
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012640 Seizures 2,4-dinitrotoluene 6.0518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.0518551238
MESH:D012871 Skin Diseases Mustard Gas 2.7312880345 15451306 16961503
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.728532709
MESH:D013088 Spermatocele Diethylstilbestrol 12.1716002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1716709447
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3217575124 12958204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.2316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.2316049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 12.231399818 15289314 15867355
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 12.2316452187 17306315 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.3910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.3910091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.1116175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.3014652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.7915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.7914692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.5416002989 16513791
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
Pathway ID Pathway Name
KEGG:04142 Lysosome
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35038
    • No data
    Releated disease ID Related disease Name
    PA446925Myoclonic Epilepsies, Progressive
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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