AutismKB 2.0

Annotation Detail for TBPL1


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Basic Information Top
Gene Symbol:TBPL1 ( MGC:8389,MGC:9620,STUD,TLF,TLP,TRF2 )
Gene Full Name: TBP-like 1
Band: 6q23.2
Quick LinksEntrez ID:9519; OMIM: 605521; Uniprot ID:TBPL1_HUMAN; ENSEMBL ID: ENSG00000028839; HGNC ID: 11589
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa03022Basal transcription factors
No data
No data
Pathway IDPathway Name
P00023General transcription regulation
P00022General transcription by RNA polymerase I
P00055Transcription regulation by bZIP transcription factor
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TBPL1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TBPL1 proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of TBPL1 mRNAincreases expression 20106945
D002945 Cisplatin Cisplatin affects the localization of TBPL1 proteinaffects localization 17085973
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TBPL1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TBPL1 mRNAaffects cotreatment|increases expression 17942748
D005047 Etoposide Etoposide affects the localization of TBPL1 proteinaffects localization 17085973
D006918 Hydroxyurea Hydroxyurea affects the localization of TBPL1 proteinaffects localization 17085973
D008741 Methyl Methanesulfonate Methyl Methanesulfonate affects the localization of TBPL1 proteinaffects localization 17085973
D008741 Methyl Methanesulfonate Methyl Methanesulfonate promotes the reaction [TBPL1 protein binds to PCNA promoter]affects binding|increases reaction 17085973
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TBPL1 mRNAaffects binding|decreases expression|increases activity 19710929
C020806 tetrabromobisphenol A tetrabromobisphenol A affects the expression of TBPL1 mRNAaffects expression 18976794
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TBPL1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0414514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D058186 Acute Kidney Injury Cisplatin 4.1012690470 15814532 17670903
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Cisplatin 4.5611798837 17638652
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5614692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 12.9714601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 12.9714601052
MESH:D001943 Breast Neoplasms Cisplatin 2.0218382427 19526202
MESH:D001943 Breast Neoplasms Etoposide 2.0216322251
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.733084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7312907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.7317982673
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0816685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.856189445 17066447 18337622
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6212371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 13.9519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.9511677210 15861022 16105132 17333356 16919318 17110522 17681005
MESH:D002779 Cholestasis pirinixic acid 13.9519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.158697196 15668235 15340226 16354765 12621046
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.6819923254 14725611 10774834 10915739 16177239 17906064 2444490 18071297 11743745 19416960 11834606 16781746 16393943 12958197 18713872 12705907 12392966 19739265 11421492 11529661 19420014 11287661 19370779 12540782 14986274 11461765 17522070 14550746 16227642 11739529 19164858 17562736 12594235 16109766 15619225 10663392 16485898 16081117 19085960 15968718 12153990
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Cisplatin 8.5212649298 12231392 15033597 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.5211462148
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004938 Esophageal Neoplasms Cisplatin 2.8117638652 16481741 15173087 16785472 15464296
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Cyclosporine 13.8319224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.8315345470
MESH:D005234 Fatty Liver pirinixic acid 13.8320131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Cyclosporine 9.0712168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0720067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.8015102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.4219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5415464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly pirinixic acid 8.8516221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8516120746 12621046 15340226
MESH:D006561 Herpes Simplex Etoposide 4.7610809021
MESH:D006689 Hodgkin Disease Cisplatin 8.2216170182 16200630
MESH:D006689 Hodgkin Disease Etoposide 8.2215147373 18180244 17606976 16200630 16135485
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.3615464296
MESH:D007674 Kidney Diseases Acetaminophen 10.5112587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 10.5119839026 12231392 18289764 12649298 15190930
MESH:D007674 Kidney Diseases Cyclosporine 10.5110903974 8314463 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.0111231351
MESH:D007951 Leukemia, Myeloid Hydroxyurea 5.1516532439
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1712878042
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 16610002 19460945 11587558 19784758 12587719 12969438 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.632125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 7.6315890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.088603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0812151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5414755239
MESH:D008175 Lung Neoplasms Cisplatin 3.546189445 11798837 17225452
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5419555203 11884234
MESH:D008223 Lymphoma Etoposide 4.0212854902 12556972
MESH:D008545 Melanoma Cisplatin 2.4918176117 12393984 12374674 15577323 11135225 16809738 12883367 16432458 18332650 18505091 16248763 17761969 17023156
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.9715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008654 Mesothelioma Cisplatin 3.2917638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009369 Neoplasms Cisplatin 5.3216773208
MESH:D009369 Neoplasms pirinixic acid 5.3217405874
MESH:D009395 Nephritis, Interstitial Cisplatin 4.7115464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009447 Neuroblastoma Cisplatin 3.518761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.898761367
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010051 Ovarian Neoplasms Cisplatin 2.9117225452 19769630 15464296 6897625
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.9119003803
MESH:D010190 Pancreatic Neoplasms Etoposide 5.9119003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.4715464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.5617638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Etoposide 3.9917172428
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D051437 Renal Insufficiency Cisplatin 4.5815464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 11.1714601052
MESH:D012512 Sarcoma, Ewing's Etoposide 11.1714601052
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.5615464296
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms Cisplatin 2.3317522103 18396642 15958060
MESH:D013736 Testicular Neoplasms Cisplatin 4.7817225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 2.9915464296 12973940 17225452
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.3416803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.7815577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6815869587 14671159
MESH:D014839 Vomiting Cisplatin 4.9311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:03022 Basal transcription factors
KEGG:05016 Huntington's disease
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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