AutismKB 2.0

Annotation Detail for EEF1E1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:EEF1E1 ( AIMP3,P18 )
Gene Full Name: eukaryotic translation elongation factor 1 epsilon 1
Band: 6p24.3
Quick LinksEntrez ID:9521; OMIM: 609206; Uniprot ID:MCA3_HUMAN; ENSEMBL ID: ENSG00000124802; HGNC ID: 3212
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Gene Expression
No data
No data
Pathway IDPathway Name
500660Cytosolic tRNA aminoacylation
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of EEF1E1 mRNAaffects expression 21346803
C075773 4-phenylbutyric acid 4-phenylbutyric acid results in decreased expression of EEF1E1 mRNAdecreases expression 14583596
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of EEF1E1 mRNAincreases expression 17484886
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EEF1E1 mRNAaffects cotreatment|affects expression 17602206
C030123 coumarin coumarin results in increased expression of EEF1E1 mRNAincreases expression 18480146
D016572 Cyclosporine Cyclosporine results in increased expression of EEF1E1 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EEF1E1 mRNAaffects cotreatment|affects expression 17602206
D010634 Phenobarbital Phenobarbital results in increased expression of EEF1E1 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of EEF1E1 mRNAincreases expression 18301758
D018038 Sodium Selenite Sodium Selenite results in increased expression of EEF1E1 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of EEF1E1 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.956195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9515322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000236 Adenoma Diethylnitrosamine 2.936695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 26.5919052882 17620307 16434500 19061943 18056438 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 26.5917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 26.5916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 26.5916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9517474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9516227642 16050911 15700767 10355542 15673190 16124888 15721981 16011737 16097048 16192424 3786805 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7416705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7420432363 16569478 19519916 16288022 11831363 19701751 16779866 18788625 20084675 16328049 18691550 18506893 16681979 18210153 19394651 20214788 19335982 19208518 3581430 16935385 18971187 17761372 18056438 20524982 18978308 19539802 18785209 20007298 16807293 20727157 19418558 3084413 10737359 16502159 17428255 17173139 21159647 17978847 20935162 19919837 18665156 19171122 19822196 19052882 19383236 18393292 17055752 17138121 18494052 16698587 17162532 20514400 16540662 20512989 10672840 16878318 19107877 20101231 16830150
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.7417173139 1701930 20007298 6705139 20935162
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.9217174075 7505956 2727394 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.434080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7416835633
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1512621046 15340226 15668235 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 7.3819647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.3820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.3817107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.4318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.4319336974 21278145 19085960 16227642 16177239 2869522 7440962 4309450 11566570 10915739 15027814 9327722 6623471 17522070 15998439 15968718 3732212 7179309 6884620 3786805 10092053 7120509
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.4319107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.4315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.4320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004421 Dystonia Phenobarbital 4.151851702
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.283659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.093922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.676401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.437750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.213659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.9612795759 61145 15959796 19224547 12631006 17595544 16045604 16239168
MESH:D005234 Fatty Liver Cyclosporine 19.9619224547
MESH:D005234 Fatty Liver Diethylnitrosamine 19.9621071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 19.9620131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 15.7718705752
MESH:D005355 Fibrosis Cyclosporine 15.7712168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.7720067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 15.4416109766
MESH:D006529 Hepatomegaly pirinixic acid 15.4416221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.4415340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 16959395 15340226 16354765 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007249 Inflammation Diethylnitrosamine 5.1218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 7.6016306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.6014714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4118776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.6716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6712371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.4416943688 11408273 17334410 21278145 17174718 17157831 16221502 11903743 16239168
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.4420032147 18665156 18522880 19638242 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 11.4421047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4615931870 15876570 16136751 17631135 15370692 12632512 17805973 16192424 15818738 17944888 16638106 18317297 18472332 15057751 14716496 18705752 14512876 16116963 12666154 18156304 18376398 17565644 16248980 18481824 16097048 18166357 18472094 12445421 12609069 16011737 18006644 17640975 16015684 15123356 17869086 18420326 18395095 17766677 17922224 15959796 18054572 17525996 15925388 15362042 12389079 18187930 17481882 13678700 12445418 18339082 15052691 12958196 17708605 12667390 14620537 18263696 18277467 11481614 17698563 17976157 17714472 18418968 16033810 20821823 18412020 14716833 12649538 15650968 15338365 15893842 14748882 14724832 18210741 12586293 17900296 18279442 17761835 15673190 18251166 10355542 17823541 18205269 12546737 18429990 12632514 18395914 15996030 17721639 15730626 12741479 17557913 16027843 12898905
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7416246199 15720792 15830285 17285989 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 6.7417034775
MESH:D008107 Liver Diseases Phenobarbital 6.7419363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8214706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 18.6319294768
MESH:D008113 Liver Neoplasms Clofibric Acid 18.6317602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.6320137499 20405173 19426721 10737359 12771043 20492335 19294768 19073162 16942905 21167192 19499222 19551842 15175105 2862719 19638242 21071580 20452335 21047994 18977376 19090486 19427195 19642983 18644402 2422723 18754104 20501860 20101389 9163691 18648771 19833225 21278145 19256749 12112319 20118626 19812893 18978307 19690152 15885732 19254457 19850985 19996281 20434301 20583210 19255062
MESH:D008113 Liver Neoplasms Phenobarbital 18.6319482888 8742319 21047994 19073162 19812893 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 18.6320007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.6316984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.8212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.8218093689 19009564 2563599 18253720 16842330 18544905 19004024 18775883 9362446 18164116 17942915 16267830 3124819 19126423 18308698 18079962 19519916 19539802 17174075 18282651 21159647 17854601
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.8217172636 1399818 2563599 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.8212151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.296695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2911884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6717484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0518551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.619029167 3581430
MESH:D009369 Neoplasms 4-phenylbutyric acid 5.6019116145
MESH:D009369 Neoplasms pirinixic acid 5.6017405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5616049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.5617016548
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4116540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4116965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 16.0112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 16.012563599
MESH:D011230 Precancerous Conditions Phenobarbital 16.012563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11896295 11222880 11399792
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3718760546
MESH:D019310 Pseudolymphoma Phenobarbital 4.7112752131
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2418551238
MESH:D012640 Seizures Phenobarbital 6.243137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.026407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.547505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.541399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3316049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5110091137
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D014689 Venous Insufficiency coumarin 5.9912708602
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
REACT:71 Gene Expression
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27648
    • No data
    No data
    Releated drug ID Related drug Name
    PA449789glycine
    PA448055l-alanine
    PA448478l-arginine
    PA449173l-cysteine
    PA10090l-glutamine
    PA449882l-histidine
    PA450197l-leucine
    PA450280l-lysine
    PA450423l-methionine
    PA450931l-phenylalanine
    PA451125l-proline
    PA451330l-serine
    PA451673l-threonine
    PA10323l-tryptophan
    PA451822l-tyrosine
    PA451843l-valine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved