AutismKB 2.0

Annotation Detail for BAG4


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Basic Information Top
Gene Symbol:BAG4 ( BAG-4,SODD )
Gene Full Name: BCL2-associated athanogene 4
Band: 8p11.23
Quick LinksEntrez ID:9530; OMIM: 603884; Uniprot ID:BAG4_HUMAN; ENSEMBL ID: ENSG00000156735; HGNC ID: 940
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200133HIV-1 Nef: Negative effector of Fas and TNF-alpha
200086TNF receptor signaling pathway
200100Ceramide signaling pathway
Pathway IDPathway Name
P00006Apoptosis signaling pathway
No data
Related Diseases/Disorders Top
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Desease IDDesease Name
1907Depression
2091Hypertension
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of BAG4 mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of BAG4 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of BAG4 mRNAdecreases expression 20504355
D019207 beta Carotene beta Carotene results in decreased expression of BAG4 mRNAdecreases expression 17034753
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of BAG4 mRNAdecreases expression 15963578
D016572 Cyclosporine Cyclosporine results in decreased expression of BAG4 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of BAG4 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of BAG4 mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of BAG4 mRNAincreases expression 18301758
C030984 pyrene pyrene results in decreased expression of BAG4 mRNAdecreases expression 15963578
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D002545 Brain Ischemia beta Carotene 5.3316157235
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0917474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 2.0920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.993786805 16124888 16192424 16097048 16050911 16011737 15721981 15673190 16227642 18705752 15700767 10355542
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9118788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8915968718 12153990 16485898 14550746 12392966 10663392 10774834 11739529 17562736 11743745 19420014 11529661 16393943 18713872 19370779 2444490 12594235 12540782 12705907 17906064 11421492 11287661 16081117 19923254 16177239 15619225 17522070 19164858 16781746 10915739 16227642 19739265 19085960 14725611 11834606 11461765 18071297 14986274 19416960 16109766 12958197
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.896623471 10915739 10092053 15968718 11566570 19085960 6884620 16177239 7120509 17522070 3732212 7440962 19336974 21278145 4309450 7179309 3786805 2869522 9327722 15027814 15998439 16227642
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.2412795759 17595544 16045604 61145 12631006 16239168 15959796 19224547
MESH:D005234 Fatty Liver Cyclosporine 20.2419224547
MESH:D005234 Fatty Liver Dietary Fats 20.2418296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver pirinixic acid 20.2420131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 16.1018705752
MESH:D005355 Fibrosis Cyclosporine 16.1012168785 12639820
MESH:D005355 Fibrosis Dietary Fats 16.1018296743
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7420471113
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.2116221962 18467677 19176532 19772884
MESH:D015658 HIV Infections beta Carotene 4.1216960176
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007249 Inflammation Dietary Fats 2.5120412841
MESH:D007333 Insulin Resistance Dietary Fats 7.6111836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.6116306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.1018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9217334410 17157831 17174718 16943688 11408273 21278145 11903743 16239168 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 6.9218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3716027843 18412020 15052691 17708605 18279442 17557913 17721639 17805973 10355542 12958196 17944888 18395914 15057751 12741479 18705752 15123356 18420326 16136751 16033810 15996030 18205269 16192424 13678700 15362042 12609069 18339082 18395095 15818738 16097048 15931870 11481614 17761835 17900296 15338365 14716833 16638106 14724832 18187930 15876570 17631135 17640975 17766677 12445421 18210741 18166357 16248980 12667390 17922224 17525996 18376398 18481824 12586293 20821823 12632512 18418968 12898905 18156304 12632514 18429990 15673190 18054572 17714472 15893842 12546737 16011737 14748882 17976157 18251166 12445418 15730626 17869086 15370692 18263696 15959796 14512876 18317297 16116963 17565644 14716496 18006644 18472332 17823541 18277467 12649538 12666154 15650968 14620537 17481882 12389079 17698563 18472094 15925388 16015684
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3715474484
MESH:D008107 Liver Diseases Acetaminophen 4.0319784758 19460945 11587558 12969438 12587719 19014921 16610002 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0315830285 17285989 15720792 16964402 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9516899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7220195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7219294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.7216377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 6.7617113696
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.7612014681 15583823
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.8920464547 18520028 18816296 17053015 18569708 6695378 20064080 20869020 20135361
MESH:D008175 Lung Neoplasms beta Carotene 2.8916401635
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009369 Neoplasms Benzo(a)pyrene 8.8211141357
MESH:D009369 Neoplasms beta Carotene 8.8217051425
MESH:D009369 Neoplasms pirinixic acid 8.8217405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity Dietary Fats 4.5618457598 21332399 16723640 19632207 20132043 17217161 11836018 20518802 18674790
MESH:D009765 Obesity pirinixic acid 4.5620558911
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4410029692 19755658
MESH:D013272 Stomach Diseases beta Carotene 5.3317638125
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013276 Stomach Ulcer beta Carotene 4.4312500499
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2317053015
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25240
  • No data
    No data
    Releated drug ID Related drug Name
    PA449780glutathione
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018