AutismKB 2.0

Annotation Detail for TP53I11


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Basic Information Top
Gene Symbol:TP53I11 ( PIG11 )
Gene Full Name: tumor protein p53 inducible protein 11
Band: 11p11.2
Quick LinksEntrez ID:9537; OMIM: NA; Uniprot ID:P5I11_HUMAN; ENSEMBL ID: ENSG00000175274; HGNC ID: 16842
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1841Stomach cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic Arsenic affects the expression of TP53I11 mRNAaffects expression 18414638
C006632 arsenic trioxide arsenic trioxide results in decreased expression of TP53I11 mRNAdecreases expression 15761015
C006632 arsenic trioxide arsenic trioxide results in increased expression of TP53I11 mRNAincreases expression 19333544
12883691
C006632 arsenic trioxide arsenic trioxide results in increased expression of TP53I11 proteinincreases expression 15225615
19333544
C006632 arsenic trioxide Cycloheximide inhibits the reaction [arsenic trioxide results in increased expression of TP53I11 mRNA]decreases reaction|increases expression 19333544
C006632 arsenic trioxide Dactinomycin inhibits the reaction [arsenic trioxide results in increased expression of TP53I11 mRNA]decreases reaction|increases expression 19333544
C006632 arsenic trioxide TP53I11 protein affects the susceptibility to arsenic trioxideaffects response to substance 19333544
C006632 arsenic trioxide TP53I11 protein results in increased susceptibility to arsenic trioxideincreases response to substance 15225615
D003513 Cycloheximide Cycloheximide inhibits the reaction [arsenic trioxide results in increased expression of TP53I11 mRNA]decreases reaction|increases expression 19333544
D003513 Cycloheximide Cycloheximide results in decreased expression of TP53I11 mRNAdecreases expression 19333544
D003609 Dactinomycin Dactinomycin inhibits the reaction [arsenic trioxide results in increased expression of TP53I11 mRNA]decreases reaction|increases expression 19333544
D003609 Dactinomycin Dactinomycin results in decreased expression of TP53I11 mRNAdecreases expression 19333544
C004742 daidzein daidzein results in decreased expression of TP53I11 mRNAdecreases expression 15757668
D004958 Estradiol Estradiol results in decreased expression of TP53I11 mRNAdecreases expression 15757668
D019833 Genistein Genistein results in decreased expression of TP53I11 mRNAdecreases expression 15757668
C086566 glycitein glycitein results in decreased expression of TP53I11 mRNAdecreases expression 15757668
D020849 Raloxifene Raloxifene affects the expression of TP53I11 mRNAaffects expression 14699072
D018038 Sodium Selenite Sodium Selenite results in decreased expression of TP53I11 mRNAdecreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of TP53I11 mRNAaffects expression 14699072
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7614745880
MESH:D000230 Adenocarcinoma arsenic trioxide 10.5319825857 11798837
MESH:D000230 Adenocarcinoma daidzein 10.5311473722
MESH:D000230 Adenocarcinoma Estradiol 10.5311473722
MESH:D000230 Adenocarcinoma Genistein 10.5311473722
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4317306315
MESH:D000419 Albuminuria Raloxifene 4.7617308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5715800139
MESH:D020261 Arsenic Poisoning Arsenic 2.9016251483 18414634 16835338 12569548
MESH:D050197 Atherosclerosis Arsenic 3.3312928151 19371607
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8116206674
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 5.7514601052
MESH:D001930 Brain Injuries Raloxifene 4.6516580743
MESH:D001943 Breast Neoplasms Estradiol 2.0012948864 18497071 17261762 19861407 14630087 17289903 16675129 17018787
MESH:D001943 Breast Neoplasms Genistein 2.0016873071 16541309 17200150
MESH:D001943 Breast Neoplasms Raloxifene 2.0016912660 15775269 17261762 15572757 17893378 17049068 17952589 17440819 16837676 15758505 17595753 17242785
MESH:D001943 Breast Neoplasms Tamoxifen 2.0019103187 16873071 17242785 15565566 16818667 11161223 18984771 18815881 19066611 19200415 20005174 19011961 18821012 17049068 20065188 19142967 18351453 19115204 19059307 21138602 19244106 19410462 16273361 19189210 19289846 19084267 18997820 21152245 18425577 17893378 19155303 18855134 19221464 19288272 19487384 19189212 18629630 17261762 20544844 16202921 20390343 20135344 20859285 17440819 15668708
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6617687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6819066611
MESH:D006528 Carcinoma, Hepatocellular Arsenic 9.1016507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 9.1014691202 11135700 15073043 15553829 16217749
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.1016924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 9.1016924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 9.1016924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7215504454 17687452 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 16.7118640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 16.7117572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 16.7117572228
MESH:D002318 Cardiovascular Diseases Arsenic 18.2015738583 19152805 17938729
MESH:D002318 Cardiovascular Diseases daidzein 18.2016332659
MESH:D002318 Cardiovascular Diseases Genistein 18.2016332659
MESH:D002318 Cardiovascular Diseases Raloxifene 18.2015775269
MESH:D002340 Carotid Artery Diseases Arsenic 4.4316973168 18022660
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8618566989
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D003072 Cognition Disorders Raloxifene 4.7915800139
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5419031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2917474826
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 5.0816647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 5.0816647724
MESH:D003928 Diabetic Nephropathies Estradiol 15.7719279558
MESH:D003928 Diabetic Nephropathies Raloxifene 15.7715920148 17308373 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 15.7719279558
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 2.3115131321
MESH:D004487 Edema Raloxifene 3.4715860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.7915845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7919031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.7816402032
MESH:D016889 Endometrial Neoplasms daidzein 18.5811473722
MESH:D016889 Endometrial Neoplasms Estradiol 18.5819148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 18.5811473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 18.5816202921 20544844 19155303 17893378
MESH:D007172 Erectile Dysfunction daidzein 5.1814972507
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3412903497
MESH:D005234 Fatty Liver arsenic trioxide 14.0615073043
MESH:D005234 Fatty Liver Raloxifene 14.0617473493
MESH:D005234 Fatty Liver Tamoxifen 14.0619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3819069698
MESH:D005534 Foot Diseases Arsenic 5.786392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D005909 Glioblastoma Genistein 3.3416598420
MESH:D006331 Heart Diseases Raloxifene 3.6311110106
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5917050553
MESH:D006973 Hypertension Arsenic 9.2016076760 11953799 9931084
MESH:D006973 Hypertension daidzein 9.2017169123
MESH:D006973 Hypertension Raloxifene 9.2017577099 15787275
MESH:D006987 Hypesthesia Arsenic 5.7816093927
MESH:D007249 Inflammation Tamoxifen 2.4219457130
MESH:D007333 Insulin Resistance Estradiol 7.7316393666 16627594
MESH:D007333 Insulin Resistance Sodium Selenite 7.7314714311
MESH:D007642 Keratosis Arsenic 5.1816930632 12749816
MESH:D007674 Kidney Diseases Estradiol 2.6615618244
MESH:D007680 Kidney Neoplasms Estradiol 7.7815610895
MESH:D007680 Kidney Neoplasms Tamoxifen 7.7818625569
MESH:D007889 Leiomyoma Raloxifene 4.6516973256
MESH:D007938 Leukemia arsenic trioxide 6.6515070760
MESH:D007938 Leukemia Genistein 6.6518980019 17468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1620471514 19850784 16467208 17050201 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.0817339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.0816112521 15748426 19075265 9834237 17649720 16330433 15622746 17217047 11468182 16331271 19225113 15336539 12712474 12018890 16823087 19035177 11161223 17107899 16891316 17712046 19642359 15213294 16966277 17869043 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D008064 Lipidoses Tamoxifen 3.2515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.6217823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.6218564211
MESH:D008107 Liver Diseases Arsenic 2.5711134558
MESH:D008113 Liver Neoplasms Arsenic 7.8216368122
MESH:D008113 Liver Neoplasms arsenic trioxide 7.8214682389
MESH:D008113 Liver Neoplasms Tamoxifen 7.8216684651
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8120377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D008175 Lung Neoplasms Arsenic 3.5917976673 19168569 17306315
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5911798837 19825857
MESH:D008175 Lung Neoplasms Tamoxifen 3.5918625569
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.4911408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.4914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 10.4919196722 11731420 16827153 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 13.3919453300
MESH:D020149 Manganese Poisoning Tamoxifen 13.3919453300
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3815990972
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7715863610
MESH:D009101 Multiple Myeloma arsenic trioxide 7.7415949261 11468182 19417148 19549372 14977855
MESH:D009101 Multiple Myeloma Raloxifene 7.7416497877
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2216105982 16882451
MESH:D009203 Myocardial Infarction Genistein 2.9117141266
MESH:D017202 Myocardial Ischemia Arsenic 4.0915371236
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.8716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.8717141266
MESH:D009232 Myxoma Raloxifene 5.7716343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2219200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009421 Nervous System Malformations Estradiol 10.3111399458 16427766
MESH:D009421 Nervous System Malformations Genistein 10.3116427766
MESH:D009436 Neural Tube Defects Arsenic 7.7416620997
MESH:D009436 Neural Tube Defects arsenic trioxide 7.7410525206
MESH:D020078 Neurogenic Inflammation Arsenic 4.5217056641
MESH:D010024 Osteoporosis Genistein 7.6119401787
MESH:D010024 Osteoporosis Raloxifene 7.6117882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.6516169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 10.6515579764 17823083 17893378 15758505
MESH:D010051 Ovarian Neoplasms Arsenic 11.6517306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.6516624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 11.6519401270
MESH:D010051 Ovarian Neoplasms Genistein 11.6519005980
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5715580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1815371236 16905509 6392382
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.1216140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1219131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.1216740699
MESH:D011471 Prostatic Neoplasms Genistein 2.1215256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1216536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.1218760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1215067354
MESH:D011507 Proteinuria Arsenic 4.1521343184
MESH:D011693 Purpura Raloxifene 5.7715770314
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 11.1316646077
MESH:D012512 Sarcoma, Ewing's Dactinomycin 11.1314601052
MESH:D012871 Skin Diseases Arsenic 2.7815952646 16353154 17453740 18709164 19834688 6392382 16702368 17050553 17548696 17938729 16759981
MESH:D012878 Skin Neoplasms Arsenic 3.0719538983 17050553 17976673 17029826 15504454 16251483
MESH:D013088 Spermatocele Tamoxifen 4.5116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2319457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Raloxifene 3.9316837676
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1919014326
MESH:D013978 Tibial Fractures Estradiol 14.4519048282
MESH:D013978 Tibial Fractures Raloxifene 14.4519048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D001749 Urinary Bladder Neoplasms Arsenic 12.3917976673 19322015 19429237 11144890 18640142 17306315 15987713
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.3912845720 12973940 20435036 11780464
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 12.3917572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.398653321 17572228 16712894
MESH:D014652 Vascular Diseases Arsenic 4.9317056641
MESH:D054556 Venous Thromboembolism Raloxifene 5.4316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7716343187
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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