AutismKB 2.0

Annotation Detail for NRG2


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Basic Information Top
Gene Symbol:NRG2 ( DON1,HRG2,NTAK )
Gene Full Name: neuregulin 2
Band: 5q31.2
Quick LinksEntrez ID:9542; OMIM: 603818; Uniprot ID:NRG2_HUMAN; ENSEMBL ID: ENSG00000158458; HGNC ID: 7998
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04012ErbB signaling pathway
No data
Pathway IDPathway Name
200009ErbB4 signaling events
200136ErbB receptor signaling network
200119ErbB2/ErbB3 signaling events
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1872Chronic simple glaucoma
1944Breast cancer
Desease Name
PSYCH
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NRG2 mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in decreased expression of NRG2 mRNAdecreases expression 20106945
D002117 Calcitriol Calcitriol results in decreased expression of NRG2 mRNAdecreases expression 16002434
D008345 Manganese Manganese results in increased expression of NRG2 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of NRG2 mRNAincreases expression 17175027
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NRG2 mRNAaffects binding|increases activity|increases expression 19710929
D020849 Raloxifene Raloxifene results in increased expression of NRG2 mRNAincreases expression 15849065
D014303 Trinitrotoluene Trinitrotoluene affects the expression of NRG2 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 4.527525203
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000419 Albuminuria Raloxifene 4.8817451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5815800139
MESH:D000756 Anemia, Sideroblastic Manganese 11.8516910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.8516910769
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001930 Brain Injuries Raloxifene 4.7816580743
MESH:D001943 Breast Neoplasms Calcitriol 2.4411237771
MESH:D001943 Breast Neoplasms Raloxifene 2.4415572757 17595753 15758505 17049068 17893378 16912660 15775269 16837676 17242785 17440819 17952589 17261762
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6811237771
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.3017572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6015775269
MESH:D002386 Cataract Trinitrotoluene 4.0015817613 14694615
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003072 Cognition Disorders Raloxifene 4.9215800139
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.6115095906
MESH:D003490 Cyanosis Trinitrotoluene 5.2318551238
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3817474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003928 Diabetic Nephropathies Raloxifene 4.1517308373 17451421 15920148
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 2.9318551238 21346803
MESH:D004487 Edema pirinixic acid 7.7012083418
MESH:D004487 Edema Raloxifene 7.7015860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 10.3415138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.3415845917
MESH:D005234 Fatty Liver Cyclosporine 14.5719224547
MESH:D005234 Fatty Liver pirinixic acid 14.5719236843 20131406
MESH:D005234 Fatty Liver Raloxifene 14.5717473493
MESH:D005355 Fibrosis Cyclosporine 3.4512168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Manganese 4.0617043766
MESH:D006331 Heart Diseases Raloxifene 3.6911110106
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly pirinixic acid 9.7918467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Trinitrotoluene 9.7915817613
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Cyclosporine 5.5610903974
MESH:D006973 Hypertension Raloxifene 5.5617577099 15787275
MESH:D007248 Infertility, Male Trinitrotoluene 3.8312150543
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D007889 Leiomyoma Raloxifene 4.7616973256
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.8920007298 16377806 15890375
MESH:D020149 Manganese Poisoning Manganese 5.9016551646 19453300 16568477
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.9315863610
MESH:D009069 Movement Disorders Manganese 5.2716551646
MESH:D009101 Multiple Myeloma Raloxifene 3.6016497877
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009232 Myxoma Raloxifene 5.9316343187
MESH:D009336 Necrosis Trinitrotoluene 5.1018551238
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D009410 Nerve Degeneration Manganese 4.4616551646
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases Trinitrotoluene 4.5617852074 12819281 14694615
MESH:D010024 Osteoporosis Raloxifene 3.5315775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4917823083 15758505 17893378 15579764
MESH:D010300 Parkinson Disease Manganese 3.4411181820
MESH:D020734 Parkinsonian Disorders Manganese 4.7016140633
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.4616289102 18247401 16644109 12479363 15754350
MESH:D011471 Prostatic Neoplasms Raloxifene 3.4616536755 15731164 16220300
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011693 Purpura Raloxifene 5.9315770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012640 Seizures Trinitrotoluene 3.5918551238
MESH:D013163 Splenomegaly Trinitrotoluene 5.5115817613
MESH:D020521 Stroke Raloxifene 4.0116837676
MESH:D013978 Tibial Fractures Raloxifene 5.5819048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.8917572228
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054556 Venous Thromboembolism Raloxifene 5.5816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.9316343187
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
KEGG:04012 ErbB signaling pathway
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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