AutismKB 2.0

Annotation Detail for H2AFY


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Basic Information Top
Gene Symbol:H2AFY ( H2A.y,H2A/y,H2AF12M,H2AFJ,MACROH2A1.1,mH2A1,macroH2A1.2 )
Gene Full Name: H2A histone family, member Y
Band: 5q31.1
Quick LinksEntrez ID:9555; OMIM: 610054; Uniprot ID:H2AY_HUMAN; ENSEMBL ID: ENSG00000113648; HGNC ID: 4740
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05322Systemic lupus erythematosus
No data
Pathway IDPathway Name
200116ATF-2 transcription factor network
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of H2AFY mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of H2AFY mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of H2AFY mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of H2AFY mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of H2AFY mRNAdecreases expression 15336504
D004317 Doxorubicin H2AFY protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of H2AFY mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of H2AFY mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of H2AFY mRNAaffects cotreatment|decreases expression 17942748
C006253 pirinixic acid pirinixic acid results in decreased expression of H2AFY mRNAdecreases expression 17426115
D020849 Raloxifene Raloxifene affects the expression of H2AFY mRNAaffects expression 16079270
D018038 Sodium Selenite Sodium Selenite results in increased expression of H2AFY mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of H2AFY mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of H2AFY mRNAaffects cotreatment|decreases expression 17942748
D014635 Valproic Acid Valproic Acid results in decreased expression of H2AFY mRNAdecreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of H2AFY mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6414745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 14.777525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 14.7711752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 14.778875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9819490988
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Doxorubicin 4.4317418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4314692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.783712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.1816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.1816835633
MESH:D000419 Albuminuria Doxorubicin 11.6821441931
MESH:D000419 Albuminuria Raloxifene 11.6817451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5515800139
MESH:D000550 Amblyopia Valproic Acid 5.3317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D001008 Anxiety Disorders Valproic Acid 9.0017497229
MESH:D001008 Anxiety Disorders vinclozolin 9.0019015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001321 Autistic Disorder Valproic Acid 2.0018316065 18558336 19460635 18985861 18940202 20603192 19232924 15238991 17157402 17507914 18775368 16609825 17688650 18396377 18177632
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1211289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.1017594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.9519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.1315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.138888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8014601052
MESH:D001930 Brain Injuries Raloxifene 4.5516580743
MESH:D001932 Brain Neoplasms Doxorubicin 3.8617150277
MESH:D001943 Breast Neoplasms Doxorubicin 1.9819526202 16595493 16096432 18234424 15939500 16322301 15136595 16935488 18628466 15993339 16264153 17983394 15994142 17426702 18695136 15668708 18382427 16115903 15567936 16826403 15692762 17369602 15634643 11325840
MESH:D001943 Breast Neoplasms Raloxifene 1.9816912660 15775269 17893378 17261762 15758505 17242785 15572757 17952589 16837676 17049068 17440819 17595753
MESH:D001943 Breast Neoplasms Tamoxifen 1.9816818667 17893378 20859285 19142967 19066611 19221464 19288272 19487384 16873071 20544844 19410462 18629630 19289846 16202921 19200415 19115204 20065188 19011961 20005174 19155303 17261762 17440819 18984771 18855134 21152245 15668708 17242785 19084267 18997820 19189210 21138602 18351453 18821012 17049068 20390343 11161223 18425577 15565566 20135344 18815881 19059307 19189212 16273361 19103187 19244106
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9116051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5819066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.667296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.6618059187 16023760 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6616924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.637296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.6316201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.656189445
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.6717572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.6717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.5616612575 17308081 17007740 16651473 15792986 15476868 16278810 15505089 16952015 16109756 17382496 17131338 15811867 16364871 16242529 18627295 16455267 17519947 17974986 16731534 17928571 17329180 17924179 16269455 17351982
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9616243910 17334414
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4815775269
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.6614694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.786135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.787505956
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.6119486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 13.6117110522 16919318 11677210 17681005 15861022 16105132 17333356
MESH:D002779 Cholestasis pirinixic acid 13.6119176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8215894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1212621046 15340226 15668235 8697196 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.6915800139
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.3515095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.3514669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4910048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.4916575769 17688650 8888407
MESH:D003456 Cryptorchidism vinclozolin 4.4114966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0918551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4319031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2117474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.878156756 8970840 12868966 2524372 18759878 11298694 14531868 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.552952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8216285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Raloxifene 9.1917451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.1919279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 18.9518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 18.9518289764 7440962 18692083 8291058 9328219 18648102 11289319 9653073 16192314 9022650 6482804 6679447 1440618
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 18.9521346803
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 18.9517416283
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 18.9515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.9520420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 18.951733752 19641884
MESH:D004362 Drug Toxicity Doxorubicin 8.2418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.2411462148
MESH:D004421 Dystonia Valproic Acid 4.111851702
MESH:D004487 Edema pirinixic acid 11.7512083418
MESH:D004487 Edema Raloxifene 11.7515860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.7512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.7412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 15.7415845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.7419031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.6817359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.6819155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2518037988
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.2317275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.013922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.637562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.377750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.153659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.2815345470
MESH:D005234 Fatty Liver pirinixic acid 25.2820131406 19236843
MESH:D005234 Fatty Liver Raloxifene 25.2817473493
MESH:D005234 Fatty Liver Tamoxifen 25.2819224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 25.2819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.9816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.1918558336 8888407
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6114745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 11.7219069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.7219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0220067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4016417039
MESH:D005909 Glioblastoma Doxorubicin 3.3817150277
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.5615692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3610048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 7.9612587719 17875725 16244371 14766674 18674790 16495754 16144979 18006777 16707910 16879835 16330681 16244372 17888722
MESH:D006331 Heart Diseases Raloxifene 7.9611110106
MESH:D006333 Heart Failure Doxorubicin 7.1617481944
MESH:D006333 Heart Failure pirinixic acid 7.1620558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9515692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006529 Hepatomegaly pirinixic acid 8.5019176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.5015340226 12621046 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 3.4517606976 18501091 15147373
MESH:D006849 Hydrocephalus Valproic Acid 4.9517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1415340226 18606429 8697196 16959395 16354765
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Raloxifene 5.2917577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.7817937319
MESH:D007248 Infertility, Male vinclozolin 6.7816467254
MESH:D007249 Inflammation Tamoxifen 4.9819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9812878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 7.4216306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.4214714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Doxorubicin 3.0815369732 16775033 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2116707910
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.6816705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.686582329
MESH:D007680 Kidney Neoplasms Tamoxifen 12.6818625569
MESH:D007889 Leiomyoma Raloxifene 4.5516973256
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2516085563
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1616294345 17596541
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8116417039
MESH:D008064 Lipidoses Tamoxifen 3.1917567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.9916595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.9918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9912878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.837678174
MESH:D008113 Liver Neoplasms pirinixic acid 10.8320007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 10.8316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.8316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.402876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.40598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 14.4017085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.4012151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3617228818
MESH:D008175 Lung Neoplasms Doxorubicin 3.4517418594 6189445
MESH:D008175 Lung Neoplasms Tamoxifen 3.4518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4519555203 11884234
MESH:D008223 Lymphoma Doxorubicin 3.5016098063
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1214737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.6415621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8419428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.2515458769
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.2516827153 11731420 19196722 14580682 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.6419453300
MESH:D008545 Melanoma Doxorubicin 3.4416827129
MESH:D008545 Melanoma Tamoxifen 3.4412393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2615990972
MESH:D008654 Mesothelioma Doxorubicin 3.0817638057
MESH:D008881 Migraine Disorders Valproic Acid 3.2318765137 18803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5515792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.6515863610
MESH:D052016 Mucositis Doxorubicin 4.8717415656
MESH:D009101 Multiple Myeloma Raloxifene 3.4716497877
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.088888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1817596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.7819429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 5.7819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009232 Myxoma Raloxifene 5.6516343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.947678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.633581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.6318259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5319410462
MESH:D009369 Neoplasms pirinixic acid 1.9717405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1019189210 19196722 19200415
MESH:D009401 Nephrosis Doxorubicin 4.8416899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.0516889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.376679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.3716359493 8888407
MESH:D009447 Neuroblastoma Doxorubicin 3.2915555623
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.4616049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.466482804 4026338
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.4614694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010024 Osteoporosis Raloxifene 3.4217882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2917823083 15579764 17893378 15758505
MESH:D012516 Osteosarcoma Doxorubicin 4.1615930896
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2517983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.2517638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.7411399792 11896295 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 16.7420603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 16.7418220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0218220299
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.1015897917 15749863 18437689 16868541 16729912 16888761
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1016220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.1018760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1015067354
MESH:D011472 Prostatitis vinclozolin 5.0218629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.6411422049 12752131
MESH:D011693 Purpura Raloxifene 5.6515770314
MESH:D051437 Renal Insufficiency Doxorubicin 4.2917922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2319155313
MESH:D012509 Sarcoma Doxorubicin 4.0415675481 15625365 17203757 16767912 18313854 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3114601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.8717846226
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 6.0618551238
MESH:D012640 Seizures Valproic Acid 6.061511512 17978042 3137016 11738929 11044598 15475178 14763951 16876388
MESH:D012878 Skin Neoplasms Doxorubicin 9.6215692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.628532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.6216192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6415625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 11.8916709447
MESH:D013088 Spermatocele Tamoxifen 11.8916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1219457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6412833885
MESH:D020521 Stroke Raloxifene 3.8616837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.403712494 6582329 1399818 6587162 7505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.4017909728 16010429
MESH:D013978 Tibial Fractures Raloxifene 5.3119048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.3317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.603119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 16.0316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 16.038074119
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 16.0317653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 16.0317572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 16.0316712894 17572228 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.718888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4010091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.3116837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.2917334414 16364871 17678736 17638931
MESH:D014846 Vulvar Neoplasms Raloxifene 5.6516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
Pathway ID Pathway Name
REACT:27235 Meiotic Recombination (mouse)
KEGG:05322 Systemic lupus erythematosus
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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