AutismKB 2.0

Annotation Detail for CHD1L


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Basic Information Top
Gene Symbol:CHD1L ( ALC1,CHDL,FLJ22530 )
Gene Full Name: chromodomain helicase DNA binding protein 1-like
Band: 1q21.1
Quick LinksEntrez ID:9557; OMIM: 613039; Uniprot ID:CHD1L_HUMAN; ENSEMBL ID: ENSG00000131778; HGNC ID: 1916
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1887Carcinoma
Desease Name
protein quantitative trait loci
Desease Name
Protein quantitative trait loci
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CHD1L mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in decreased expression of CHD1L mRNAdecreases expression 20106945
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CHD1L mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of CHD1L mRNAincreases expression 19482888
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CHD1L mRNAincreases expression 15328365
D014303 Trinitrotoluene Trinitrotoluene affects the expression of CHD1L mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 17.706195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 17.7014514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 17.707525203
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.9517620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.9516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.013084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.0120007298 20935162 1701930 6705139 17173139
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 8.1410977129
MESH:D002386 Cataract Trinitrotoluene 8.1415817613 14694615
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2212621046 8697196 15668235 16354765 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 10.3817141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 10.3815095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003490 Cyanosis Trinitrotoluene 5.4118551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.7419370779 10663392 16485898 12153990 19923254 17906064 2444490 10915739 11739529 14725611 14550746 12958197 19164858 18071297 11743745 12540782 18713872 16227642 12594235 17522070 16393943 11461765 17562736 11287661 15619225 11529661 19420014 19739265 16109766 12705907 19085960 14986274 16177239 19416960 16081117 11834606 15968718 16781746 10774834 11421492 12392966
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.7420420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 6.7418551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004421 Dystonia Phenobarbital 4.411851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5118230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3710568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.4811558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.876401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.563659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Cyclosporine 3.2319224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Cyclosporine 10.1412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.1420067830
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4911294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Phenobarbital 17.5716109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 17.5715340226 16120746 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 17.5715817613
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6618606429 8697196 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006973 Hypertension Cyclosporine 5.3110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3118670907 18850075
MESH:D007248 Infertility, Male Trinitrotoluene 3.9012150543
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Acetaminophen 6.4112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.4118776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0412371664
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0721047994
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 4.1719460945 11587558 19014921 16611625 19784758 12587719 12969438 16610002
MESH:D008107 Liver Diseases Phenobarbital 4.1719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 4.7919812893 15975961 8742319 19073162 21047994 19482888
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7916984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.481399818 18308698 2563599 17172636 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4812151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009336 Necrosis Trinitrotoluene 5.3018551238
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009784 Occupational Diseases Trinitrotoluene 4.6817852074 14694615 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5916965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011230 Precancerous Conditions Cyclosporine 10.0712371664
MESH:D011230 Precancerous Conditions Phenobarbital 10.072563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311118676 11896295 11222880 11399792
MESH:D019310 Pseudolymphoma Phenobarbital 5.1112752131
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012640 Seizures Phenobarbital 7.044039156 3137016 16876388 11442880
MESH:D012640 Seizures Trinitrotoluene 7.0418551238
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1816192470
MESH:D013163 Splenomegaly Trinitrotoluene 5.6915817613
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.321399818
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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